Abstract:BCC, Basal cell carcinoma; SCC, squamous cell carcinoma. *Statistical significance established at P \ .05. y Anatomic locations of tumors were significantly different in the study population. z Area H: mask areas of face (central face, eyelids [including inner/outer canthi], eyebrows, nose, lips [cutaneous/mucosal/vermillion], chin, ear and periauricular skin/sulci, temple), genitalia (including perineal and perianal), hands, feet, nail units, ankles, and nipples/areola.x Area M: cheeks, forehead, scalp, neck,… Show more
“…Consistent with prior studies, we found a similar mean age at presentation for Hispanic and NHW individuals with BCC 5 . NHW men presented more frequently with BCC compared with women.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...supporting
confidence: 91%
“…To our knowledge this finding has not been previously reported. The finding in our study and studies by others, showing that Hispanic individuals are more likely to present with BCC in high‐risk locations, may account for the higher incidence of flap closures we observed 5 . Tissue rearrangement is often required in the high‐risk mask areas of the face to preserve functional anatomy.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...supporting
confidence: 73%
“…This finding is similar to that of Perper et al . in which keratinocyte carcinoma in Hispanic individuals were primarily located in area H 5 . NMSC has a lower incidence in skin of colour and requires a high degree of clinical suspicion for accurate and timely diagnosis.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...mentioning
“…Consistent with prior studies, we found a similar mean age at presentation for Hispanic and NHW individuals with BCC 5 . NHW men presented more frequently with BCC compared with women.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...supporting
confidence: 91%
“…To our knowledge this finding has not been previously reported. The finding in our study and studies by others, showing that Hispanic individuals are more likely to present with BCC in high‐risk locations, may account for the higher incidence of flap closures we observed 5 . Tissue rearrangement is often required in the high‐risk mask areas of the face to preserve functional anatomy.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...supporting
confidence: 73%
“…This finding is similar to that of Perper et al . in which keratinocyte carcinoma in Hispanic individuals were primarily located in area H 5 . NMSC has a lower incidence in skin of colour and requires a high degree of clinical suspicion for accurate and timely diagnosis.…”
Section: Hispanic Individuals (N = 244) Non‐hispanic White Individual...mentioning
“…4 Studies outside the Medicare population have often noted a predominance of BCC in younger patients but with widely varying point estimates of the relative burden of BCC to cSCC. [3][4][5] Finally, data on KCs in patients with skin of color in the United States are limited, mostly to regional 6,7 or single-center [8][9][10][11][12][13][14][15] data. Importantly, none of these prior analyses have attempted to simultaneously analyze and adjust their estimates for age, sex, and race; and given that they derive from geographically restricted populations, the geographic variation in the BCC:cSCC ratio is poorly understood.…”
IMPORTANCE Defining which populations are affected by basal cell carcinoma (BCC) vs cutaneous squamous cell carcinoma (cSCC) may inform targeted public health strategies. Incidence of BCC and cSCC is not reported to national cancer registries, but claims data for the treatment of BCC and cSCC provide insights into the epidemiology of keratinocyte carcinoma.OBJECTIVE To define differences in the ratio of BCC to cSCC in adults (age, Ն18 years) in a large database of patients with commercial insurance and Medicare Advantage coverage.
DESIGN, SETTING, AND PARTICIPANTSThis cross-sectional analysis used deidentified data derived from the Optum Clinformatics Data Mart to perform a retrospective evaluation of a large commercially insured cohort based on treatment claims from January 1, 2012, to December 31, 2016. Patients with a diagnosed and treated BCC or cSCC as determined by codes from the
eratinocyte carcinoma comprises basal and squamous cell carcinomas, and is the most common malignant dis ease in Canada and the United States. [1][2][3][4][5] Although kera tinocyte carcinoma has a low mortality rate, it is associated with substantial morbidity and impaired quality of life. 2,6,7 Among can cers, it also ranks fifth in health care costs in the US. 8 Epidemiological studies of keratinocyte carcinoma in North America are limited by its exclusion from most cancer regis tries. 9 Previous studies found that higher overall incidence of keratinocyte carcinoma is associated with male sex, 10-14 older age [15][16][17] and higher socioeconomic status. [18][19][20][21] However, differ ences in the incidence and mortality rates of keratinocyte car cinoma by sex in relation to age and socioeconomic status have not been well characterized.A better understanding of the epidemiology of keratinocyte carcinoma in Canada and differences by sex would inform public health initiatives, health services policy and patient education strategies. This is particularly relevant now, given the recent regu latory approval of systemic immunotherapies for locally advanced or metastatic squamous and basal cell carcinoma. [22][23][24][25] Our objective was to identify the populationbased incidence and mortality trends of keratinocyte carcinoma in Ontario, Canada over 2 decades and to evaluate sex differences.
MethodsWe conducted a populationbased, retrospective observa tional study of health administrative data sets that were linked using unique encoded identifiers and analyzed at ICES. We reported the study according to the Reporting of Studies Con ducted Using Observational RoutinelyCollected Health Data (RECORD) checklist. 26 Research Incidence and mortality rates of keratinocyte carcinoma from 1998-2017: a population-based study of sex differences in Ontario, Canada
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