Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin

Hobbs, Ryan P.; Lessard, Juliane C.

doi:10.1242/jcs.122929

Cited by 40 publications

(36 citation statements)

References 17 publications

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“…These findings indicating upregulated and retained K14 expression are consistent with our findings. In addition, there are studies reporting that K14 might even actively take part in the immune responses . Similarly Leigh et al .…”

Section: Discussionmentioning

confidence: 76%

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Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases

et al. 2015

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Section: Discussionmentioning

confidence: 76%

“…In addition, there are studies reporting that K14 might even actively take part in the immune responses. 21 Similarly Leigh et al 22 and Depianto et al 23 demonstrated that another major keratin of basal cells, K17, is a marker of keratinocyte hyperproliferation in psoriasis and promoted epithelial proliferation in skin.…”

Section: Discussionmentioning

confidence: 95%

Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases

et al. 2015

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“…Keratins play multiple significant roles in epithelium, including intermediate filament formation (19), inflammatory responses (5,17) and cellular signaling (1,6).…”

Section: Discussionmentioning

confidence: 99%

Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse

Tao

et al. 2018

Preprint

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Our recent studies have suggested that characteristic 'Pattern of Autofluorescence (AF)' of each disease could be a novel biomarker for non-invasive diagnosis of multiple major diseases such as acute ischemic stroke. It is necessary to determine if increased epidermal green AF may be produced by major pathological factors such as inflammation. In our current study, we used C57BL/6Slac mice exposed to LPS to test our hypothesis that inflammation may induce increased epidermal green AF: LPS rapidly induced significant increases in the epidermal green AF of the mice's ears at 1 hr after LPS injection. LPS also dose-dependently increased the epidermal green AF. The AF intensity had a linear relationship with the LPS dosages at both 3 and 7 days after the LPS administration. The AF images exhibited the characteristic structure of the keratinocytes in Stratum Spinosum, suggesting that the origin of the increased AF was keratin 1 and/or keratin 10.Collectively, our current study has provided the first evidence indicating that inflammation can rapidly and dose-dependently induce increased epidermal green AF, suggesting that the green AF may be the first biomarker for non-invasive and rapid detection of systemic inflammation. Since inflammation is a key pathological factor of numerous diseases, our finding has highlighted the value of the epidermal AF as a novel diagnostic biomarker for numerous diseases.

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“…It remains unclear how Aire is functioning in these cells, given that these Aire‐expressing thymic B cells were not enriched for tissue‐specific antigens (TSAs). In addition to thymic B cells, keratinocytes were also shown to express Aire under an inflammatory condition in an oncogenic‐driven tumor model . In this setting, Aire itself may be a contributor to the transformation process, but precisely how this happens and how widespread this process is in other tumors remains to be determined.…”

Section: Immunological Functions Of Airementioning

confidence: 99%

Central tolerance to self revealed by the autoimmune regulator

Chan

Anderson

2015

Annals of the New York Academy of Sciences

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The autoimmune regulator (Aire) was initially identified as the gene causing multiorgan system autoimmunity in humans, and deletion of this gene in mice also resulted in organ-specific autoimmunity. Aire regulates the expression of tissue-specific antigens (TSAs) in medullary thymic epithelial cells (mTECs), which play a critical role in the negative selection of autoreactive T cells and the generation of regulatory T cells. More recently, the role of Aire in the development of mTECs have helped elucidate its ability to present the spectrum of TSAs needed to prevent autoimmunity. Molecular characterization of the functional domains of Aire have revealed multiple binding partners that assist Aire’s function in altering gene transcription and chromatin remodeling. These recent advances have further highlighted the importance of Aire in central tolerance.

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Keratin intermediate filament proteins – novel regulators of inflammation and immunity in skin

Cited by 40 publications

References 17 publications

Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases

Altered expression of keratin 14 in lesional epidermis of autoimmune skin diseases

Lipopolysaccharide (LPS) induces increased epidermal green autofluorescence of mouse

Central tolerance to self revealed by the autoimmune regulator

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