Keratin and keratinization

Smack, David Phillips; Korge, Bernhard; James, William D.

doi:10.1016/s0190-9622(94)70012-5

Cited by 103 publications

(64 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Very little is known concerning pathological expression of hard keratins (Smack et al 1994 an extremely heterogeneous disease (Lonn et al 1994). and hHbl 5'-truncated mRNA might permit the discrimination between particular subtypes of breast cancer.…”

Section: Resultsmentioning

confidence: 99%

Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

Régnier

Boulay²,

Asch³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

Summary Human hHbl beings to the type 11 hard keratin family and is physiologically expressed in hair shafts. In the present study, using specific 3' and 5' probes for hHbl, we established that breast carcinomas ectopically express a hHbl 5'-truncated mRNA, and that this transcript is restricted to malignant epithelial cells. Furthernore, an in vitro study indicated that it could be twanslated. We concluded that, in breast carcinomas, expression of truncated hHbl is related to epithial cell transformation. Because the hHbl gene maps to 12q11-q13, a chromosome region known to present several breakpoints in solid tumours, we propose that the hHbl gene might represent a target for such alterations.

show abstract

Section: Resultsmentioning

confidence: 99%

Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

Régnier

Boulay²,

Asch³

et al. 1998

Br J Cancer

View full text Add to dashboard Cite

show abstract

“…They finally lose both their nuclei and their cellular organelles and desquamate as horny cells filled with masses of keratohyalin and keratin filaments [2,20,25]. The morphological changes in keratinocyte nuclei during keratinization are similar to those which occur in apoptosis and may correlate with the following biochemical findings in epidermis: the nuclear DNA content of keratinocytes is highest in the basal layer [21], and some DNase activities are strongest in the horny layer [15].…”

mentioning

confidence: 99%

The Relationship between Apoptosis and Keratinization in Human Epidermis.

Nakamura¹,

Ito

Matsumoto

et al. 1999

Acta Histochem. Cytochem

View full text Add to dashboard Cite

“…Es un transtorno adquirido de la queratinización, en el cual los gránulos de profilagrina no se diluyen para formar filagrina y envolver los filamentos de queratina sino que persisten como tales en la capa córnea. La profilagrina es el componente principal de los gránulos de queratohialina (10). Es una proteína fosforilada, insoluble, rica en histidina que origina doce moléculas de filagrina por hidrólisis con proteasas y fosfatasas (10).…”

Section: Discussionunclassified

“…La profilagrina es el componente principal de los gránulos de queratohialina (10). Es una proteína fosforilada, insoluble, rica en histidina que origina doce moléculas de filagrina por hidrólisis con proteasas y fosfatasas (10). A su vez, la filagrina es un aglutinante de los filamentos de queratina, a los que ayuda a agruparse de manera precisa para establecer enlaces disulfuro, todo lo cual da estabilidad y firmeza a la capa córnea.…”

Section: Discussionunclassified

“…A su vez, la filagrina es un aglutinante de los filamentos de queratina, a los que ayuda a agruparse de manera precisa para establecer enlaces disulfuro, todo lo cual da estabilidad y firmeza a la capa córnea. La filagrina es una molécula pequeña de vida efímera, cuya hidrólisis origina ácido urocánico, un protector contra la luz ultravioleta (10). Se puede sugerir que la substancia desencadenante de la paraqueratosis granulosa podría actuar inhibiendo la acción enzimática de las proteasas y fosfatasas que clivan la profilagrina, aunque otras hipótesis son posibles.…”

Section: Discussionunclassified

See 1 more Smart Citation

Paraqueratosis granulosa de la axila.

Rodríguez¹

2002

biomedica

View full text Add to dashboard Cite

La paraqueratosis granulosa de la axila es un transtorno adquirido de la cornificación, en el cual la capa córnea es muy gruesa y conserva los gránulos de profilagrina (queratohialina). Se han publicado 32 casos desde su descripción en 1991, de Estados Unidos, Europa y Australia. No conocemos informes de la entidad en Latinoamérica. Estudiamos tres mujeres obesas que presentaron pápulas y placas axilares, costrosas, hiperqueratósicas e hiperpigmentadas, que se diagnosticaron clínicamente como pénfigo familiar benigno o tinea nigra. Las biopsias mostraron enorme capa córnea paraqueratósica con aspecto basófilo dado por la presencia de gránulos de queratohialina, identificados con la hematoxilina-eosina y con microscopía electrónica del tejido obtenido del bloque de parafina. La inmunohistoquímica para S-100 no demostró células de Langerhans en las lesiones. La coloración de PAS no demostró hongos. Los infundíbulos presentaron voluminosos tapones córneos con el mismo cambio. No se vió mayor inflamación dérmica. Estos hallazgos sugieren que la entidad es una dermatitis de contacto irritativo. Las historias clínicas y la revisión de la literatura indican que el uso de desodorantes, la obesidad y la humedad son los factores desencadenantes. El diagnóstico debe ser realizado sin dificultad por el patólogo o el dermatopatólogo, ya que por ser una entidad relativamente nueva no es fácil reconocerla clínicamente.Palabras clave: paraqueratosis granulosa, queratinización alterada, gránulos de profilagrina. Axillary granular parakeratosisAxillary granular parakeratosis is an alteration of keratin characterized by a thick parakeratotic horny layer with abundant intracellular keratohyalin granules. It was first described in 1991 and since then 32 cases have been reported from USA, Europe and Australia. Lesions may affect intertriginous areas other than the axilla. The disease has apparantly not been previously described in Latin America. Three overweight Colombian women were diagnosed with axillary granular parakeratosis. They presented encrusted, hyperkeratotic, hyperpigmented and pruriginous papules and plaques which affected both axillae in two women and only one in the other. Lesions had persisted for two and four months in two patients and for one year in the third. Clinical diagnoses were benign familiar pemphigus and tinea nigra. Skin biopsies showed a thick parakeratotic basophilic horny layer. Electron microscopy demonstrated a high content of keratohyalin granules. No Langerhans cells were demonstrated in the lesions using IHC for S-100 protein. No fungi were seen with the PAS stain. Infundibula showed thick horny plugs with changes similar to those seen in the epidermis. Dermal tissue showed few perivascular lymphocytes. These findings suggest that the disease has an irritative pathogenesis. Clinical histories indicated that the three women were overweight and used several types of antiperspirants. These factors plus local irritation and humidity apparently triggered the keratinization response.

show abstract

Keratin and keratinization

Cited by 103 publications

References 105 publications

Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

Expression of a truncated form of hHb1 hair keratin in human breast carcinomas

The Relationship between Apoptosis and Keratinization in Human Epidermis.

Paraqueratosis granulosa de la axila.

Contact Info

Product

Resources

About