Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations

Louw, Louise

doi:10.1054/plef.2000.0209

Cited by 28 publications

(30 citation statements)

References 32 publications

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“…58 Similarly, another approach, the application of snake oil in traditional African medicine, is a nutrition-based therapy that seems to have some efficacy. 59 Finally, other interventions relate to some extent to the immunomodulation theory described above: they include imiquimod 5% cream application. 60 However, the exact mechanisms involved remain to be clarified.…”

Section: Current Clinical Therapies For Pathological Scarringmentioning

confidence: 99%

Keloids and Hypertrophic Scars

Huang

Murphy

Akaishi

et al. 2013

Plastic and Reconstructive Surgery Global Open

122

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Summary:The development of cutaneous pathological scars, namely, hypertrophic scars (HSs) and keloids, involves complex pathways, and the exact mechanisms by which they are initiated, evolved, and regulated remain to be fully elucidated. The generally held concepts that keloids and HSs represent “aberrant wound healing” or that they are “characterized by hyalinized collagen bundles” have done little to promote their accurate clinicopathological classification or to stimulate research into the specific causes of these scars and effective preventative therapies. To overcome this barrier, we review here the most recent findings regarding the pathology and pathogenesis of keloids and HSs. The aberrations of HSs and keloids in terms of the inflammation, proliferation, and remodeling phases of the wound healing process are described. In particular, the significant roles that the extracellular matrix and the epidermal and dermal layers of skin play in scar pathogenesis are examined. Finally, the current hypotheses of pathological scar etiology that should be tested by basic and clinical investigators are detailed. Therapies that have been found to be effective are described, including several that evolved directly from the aforementioned etiology hypotheses. A better understanding of pathological scar etiology and manifestations will improve the clinical and histopathological classification and treatment of these important lesions.

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Section: Current Clinical Therapies For Pathological Scarringmentioning

confidence: 99%

Keloids and Hypertrophic Scars

Huang

Murphy

Akaishi

et al. 2013

Plastic and Reconstructive Surgery Global Open

122

View full text Add to dashboard Cite

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“…Keloid formation is characterized by active angiogenesis, hypoxia and occlusion of some microvessels by excessive endothelial cells, which may lead to local hypoxic conditions and apoptosis [16,18]. Accordingly, keloids can be divided into: interface and peripheral areas characterized by angiogenesis, proliferating fibroblast populations and enhanced collagen production; central areas characterized by hypoxia, apoptosis and an abundance of collagen [16,[18][19][20]. Several modalities of treatment have been reported, one of which is laser.…”

Section: Discussionmentioning

confidence: 99%

Management of ear lobule keloids using 980-nm diode laser

Kassab

Kharbotly

2011

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the 980-nm diode laser in conjunction with corticosteroids in the treatment of ear lobule keloids. Several methods have been described for the treatment of keloid scars, but none of them have been 100% successful. Advances in laser techniques have enabled surgeons to define the most appropriate lasers for use in the treatment of different scar types. The diode laser pulses are delivered interstitially in a single repeated mode in non-overlapping sites using a bare optical fiber, followed by intralesional triamcinolone acetonide injection. The number of sessions varies between two to five for the management of more than 75% of keloid size, with a total success rate of 75% and no recurrence in the follow-up of 12 months. The technique used proved to be effective in the treatment of ear lobule keloids.

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“…Moreover, lipids are involved in scar formation and wound healing (Louw 2000;Shakespeare and Strange 1981;Balazs et al 2001;Tachi 1998;Cardoso et al 2004), and arachidonic acid has been shown to play a role in scar formation (Nomura et al 2007). Therefore, since lipid analysis can provide insight into changes in cell morphology, proliferation, and differentiation, we compared the fatty acid composition of total lipids from each sample extracted by WC and the paired TLC-extracted fraction.…”

Section: Fatty Acid Composition Of Fibroblasts In Each Mediummentioning

confidence: 99%

Use of synthetic serum-free medium for culture of human dermal fibroblasts to establish an experimental system similar to living dermis

et al. 2014

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In this study, we sought to establish a defined experimental system for fibroblast growth similar to that of the living dermis. To this end, we evaluated the growth and biochemical characteristics of fibroblasts cultured with serum-free HFDM-1, a finely tuned synthetic medium for human fibroblast culture. Three culture conditions were used to grow fibroblasts obtained from primary culture: (1) culture with Dulbecco's modified Eagle medium (DMEM) plus 10 % fetal bovine serum (serum-supplemented DMEM), (2) culture with DMEM (serum-free DMEM), and (3) culture with HFDM-1 (HFDM-1), and fibroblast morphology, growth, collagen type I production, and lipid composition were analyzed. Fibroblasts grown in HFDM-1 maintained cell numbers at nearly 100 % from days 14 to 21 and produced more collagen type I than cells grown in serum-supplemented and serum-free DMEM. Arachidonic acid (20:4) and total polyunsaturated fatty acids were lower in cells grown in serum-free DMEM and HFDM-1 than in serum-supplemented DMEM. These results suggested that HFDM-1 recapitulated growth conditions in the dermis better than traditional, serum-supplemented DMEM. In addition, the controlled chemical composition of HFDM-1 eliminated a potential source of variability in cell culture conditions.

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Keloids in rural black South Africans. Part 3: a lipid model for the prevention and treatment of keloid formations

Cited by 28 publications

References 32 publications

Keloids and Hypertrophic Scars

Keloids and Hypertrophic Scars

Management of ear lobule keloids using 980-nm diode laser

Use of synthetic serum-free medium for culture of human dermal fibroblasts to establish an experimental system similar to living dermis

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