Keloids and Hypertrophic Scars: Results With Intra‐operative and Serial Postoperative Corticosteroid Injection Therapy

Chowdri, Nisar Ahmad; Mattoo, Mohammad Masarat Ajaz; Darzi, Mohammad Ashraf

doi:10.1046/j.1440-1622.1999.01658.x

Cited by 109 publications

(54 citation statements)

References 30 publications

(50 reference statements)

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“…Therefore, the follow-up period would be a key factor. It has been reported that 5.5-12.9 months elapsed on average until the recurrence following the treatment [7]. At our institution, there were no notable episodes such as tissue atrophy, telangiectasia for- As shown in our case, there is a possibility that keloid might occur in the axilla.…”

Section: Discussionsupporting

confidence: 53%

“…Therefore, local steroid injections are frequently used as adjuvant therapy to surgery for the purposes of inhibiting the expression of collagen genes in patients with keloid [6]. Chowdri et al reported that the recurrence rate was 8.1% during a followup period of 30 months following a concomitant use of surgery with local steroid injections, thus advocating the efficacy of the combination of the two methods [7]. It can therefore be stated that the combination of surgical excision and local steroid injections is currently the most popular modality.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Axillary Keloid Formation after Osmidrosis Surgery

Hwang

Lee

Kim

et al. 2013

Arch Aesthetic Plast Surg

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Axillary Keloid Formation after Osmidrosis Surgery

Hwang

Lee

Kim

et al. 2013

Arch Aesthetic Plast Surg

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“…101 Several noncontrolled studies have shown that the majority of patients experience improvement of the keloid without recurrence after steroid injection. [113][114][115][116] In one controlled study, patients with keloid scars underwent surgical excision and were then randomized to corticosteroid injection (16 mg triamcinolone on postoperative days 0, 7, 21, and 35) or radiation therapy (single dose of 700 or 1,000 cGy). After 30 months of follow-up, no significant difference was found between the treatment arms, and only 22% of patients experienced recurrence.…”

Section: Stem Cells In 2009 Biernaskie Et Al Deter-mentioning

confidence: 99%

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Marshall

Leavitt

et al. 2018

Advances in Wound Care

220

176

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Significance: Scarring of the skin from burns, surgery, and injury constitutes a major burden on the healthcare system. Patients affected by major scars, particularly children, suffer from long-term functional and psychological problems. Recent Advances: Scarring in humans is the end result of the wound healing process, which has evolved to rapidly repair injuries. Wound healing and scar formation are well described on the cellular and molecular levels, but truly effective molecular or cell-based antiscarring treatments still do not exist. Recent discoveries have clarified the role of skin stem cells and fibroblasts in the regeneration of injuries and formation of scar. Critical Issues: It will be important to show that new advances in the stem cell and fibroblast biology of scarring can be translated into therapies that prevent and reduce scarring in humans without major side effects. Future Directions: Novel therapies involving the use of purified human cells as well as agents that target specific cells and modulate the immune response to injury are currently undergoing testing. In the basic science realm, researchers continue to refine our understanding of the role that particular cell types play in the development of scar. SCOPE AND SIGNIFICANCEThis review begins with an overview of how human skin wounds heal, with an emphasis on the formation of scar as the end result of wound healing. This is followed by a review of recent developments in the cellular biology of wound healing and scarring, particularly related to stem cells and fibroblasts. Finally, traditional and novel treatments intended to prevent and reduce scarring are described. This review will be of interest to clinicians and basic scientists who wish to better understand the processes of wound healing and scarring as well as the treatment options available. TRANSLATIONAL RELEVANCEA great deal has been learned about the cellular and molecular pathways that contribute to scar formation. At the same time, clinicians have understood for centuries that certain techniques allow wounds to heal faster with less scarring. Despite the enormity of the clinical problem presented by scarring, there has been a failure to translate the basic science of scarring into improved scarring treatments that take advantage of specific molecular and cellular targets. However, in the field, there is optimism that recent advances will bridge the gap between the basic science and the clinical treatment of scarring. CLINICAL RELEVANCE Scarring of the skin affects millions of patients and in some, particularly children and burn victims, causes a great deal of suffering. Scar prevention mainly consists of the principles of wound closure without tension and avoiding infection and wound breakdown. Various treatments for established scars exist, with varying levels of effectiveness. Burn scars are particularly challenging, and treatment is largely supportive with the option for revision surgery to remove scarred skin. A novel drug-based treatment that makes use of a specific mole...

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“…After treating the patients for a minimum of 8 weeks, the majority of patients achieved a greater than 50% response with a mean (SD) scar volume at the start of 0.73 (0.701) mL reduced to 0.14 (0.302) mL. 3 Chowdri et al 4 reviewed their experience with 58 keloids and hypertrophic scars using intralesional corticosteroid injection. After doing serial injections at weekly intervals for 2 to 5 weeks followed by monthly injections for 4 to 6 months, more than 90% of the patients had no evidence of a recurrence at a mean follow-up of 30.5 months.…”

Section: Nonsurgical Therapy Corticosteroidsmentioning

confidence: 99%

Scar Revision Review

Thomas

Somenek

2012

Arch Facial Plast Surg

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Scars are a natural part of dermal healing following lacerations, incisions, or tissue loss. They can vary in quality depending on the individual's racial characteristics, the mechanism of the trauma, and conditions in which the wound healed-all of which are factors beyond the surgeon's control. A scar on the face can have significant implications for the patient. What may seem like an insignificant issue to the casual observer can cause continuous frustration for the patient, affecting their daily lives. These can include psychological as well as social consequences, leading to a diminished quality of life. Factors that the surgeon can control include the favorable repositioning of the scar, proper alignment of the wound edges, and meticulous handling of the tissues.

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Keloids and Hypertrophic Scars: Results With Intra‐operative and Serial Postoperative Corticosteroid Injection Therapy

Abstract: Because of promising results, further use and evaluation of this method of treatment is recommended for large, recurrent and complicated keloids and hypertrophic scars.

Cited by 109 publications

References 30 publications

Axillary Keloid Formation after Osmidrosis Surgery

Axillary Keloid Formation after Osmidrosis Surgery

Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions

Scar Revision Review

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