Keloidal-like local recurrence after infiltrating adenosquamous breast carcinoma with stromal-overgrowth mimicking a benign skin lesion

Abstract

We present a very rare case of an adenosquamous infiltrating breast carcinoma with sarcomatous stromal overgrowth of hypocellular collagenised type, which subsequently developed local recurrence, mistaken for a benign skin lesion due to bland keloid-like morphological appearance. All the histological, immunohistochemical, and clinical features must be taken into consideration when distinguishing between a benign skin lesion and a local recurrence of a rare subtype of breast carcinoma.

Adenosquamous Carcinoma of the Breast: Case Report and Literature Review

“…Adjuvant chemoradiotherapy may be associated with improved survival only for tumors larger than 3 cm or confirmed lymphovascular invasion or nodal metastasis on histopathological examination. The current literature mentions just 1 case of local breast skin recurrence, which had a keloidal component and was managed with excision and close observation [ 17 ].…”

Low-grade adenosquamous carcinoma of the breast: a review with focus on imaging and management

“…Only one case of local breast skin recurrence was reported in the literature: it was mainly composed of a keloid-type mesenchymal component, and was observed after conservative surgical approach to an adenosquamous carcinoma of the breast with sarcomatous stromal overgrowth (SO). 42 The tumor was associated with the rapid development of brain and skull metastases. The local recurrence lacked any squamous component and only presented a few benign-looking glandular structures, initially misinterpreted as a benign skin lesion.…”