Kefiran-alginate gel microspheres for oral delivery of ciprofloxacin

Blandón, Lina M.; Islan, Germán Abel; Castro, Guillermo R.; Noseda, Miguel D.; Soccol, Vanete Thomaz; Soccol, Carlos Ricardo

doi:10.1016/j.colsurfb.2016.05.078

Cited by 41 publications

(24 citation statements)

References 22 publications

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“…Dari sepuluh artikel yang ditinjau, semua penelitian yang dilakukan review paper ini menggunakan study design eksperimental (Shahzad et al, 2015;Chen et al, 2017;Ng & Leow, 2015;Jayakumar et al, 2015;Sebria & Amin, 2016;Phaechamud et al, 2016;Kurczewska et al, 2017;Güneş & Tıhmınlıoğlu, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017). Terdapat tiga penelitian menggunakan hidrogel (Shahzad et al, 2015;Chen et al, 2017;Sebria & Amin, 2016), dua penelitian menggunakan natural rubber films dan chitosan films (Phaechamud et al, 2016;Güneş & Tıhmınlıoğlu, 2017), dan satu penelitian menggunakan biofilm (Ng & Leow, 2015), serta empat penelitian menggunakan alginate (Jayakumar et al, 2015;Kurczewska et al, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Terdapat tiga penelitian menggunakan hidrogel (Shahzad et al, 2015;Chen et al, 2017;Sebria & Amin, 2016), dua penelitian menggunakan natural rubber films dan chitosan films (Phaechamud et al, 2016;Güneş & Tıhmınlıoğlu, 2017), dan satu penelitian menggunakan biofilm (Ng & Leow, 2015), serta empat penelitian menggunakan alginate (Jayakumar et al, 2015;Kurczewska et al, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Sedangkan Hidrogel GG dapat menghambat bakteri Gram positif, yaitu Staphylococcus Aureus (Sebria & Amin, 2016). Dua artikel yang membahas tentang dressing film topografi menunjukkan aktivitas antimikroba yang baik terhadap Staphylococcus Aureus, Pseudomonas aeruginosa dan Escherichia coli (Phaechamud et al, 2016;Güneş & Tıhmınlıoğlu, 2017 (Jayakumar et al, 2015;Kurczewska et al, 2017;Blandón et al, 2016;Hajimirzababa et al, 2017).…”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

“…Karena, Antimikroba yang ada pada balutan luka dapat membunuh bakteri yang ada pada luka (Darwis, Basyir, Hardiningsih, & Chosdu, 2013). Jenis antimikroba yang digunakan dalam modern wound dressing seperti: Cefixime (Shahzad et al, 2015), Tetracycline (Chen et al, 2017), Gentamicin (Ng & Leow, 2015), Penicillin G-P10 (Sebria & Amin, 2016), Tetramethylrodamine (Jayakumar et al, 2015), Gentamicine Sulfate (Phaechamud et al, 2016), Vancomycin Hydrochloride (Kurczewska et al, 2017), Penicillin dan Streptomycin (Güneş & Tıhmınlıoğlu, 2017), Chiprofloxacine (Blandón et al, 2016) …”

Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

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Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Gito

Rochmawati

2018

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ABSTRAKLuka diklasifikasikan sebagai akut dan kronis. Tahap awal pembentukan luka kronis ditandai dengan munculnya organisme Gram-positif seperti Staphylococcus Aureus dan Escherichia coli. Pada tahap selanjutnya, Gram-negatif spesies Pseudomonas yang cenderung menyerang lapisan dalam pada luka. Modern wound dressing yang mengandung antimikroba telah dikembangkan sejak dua puluh tahun terakhir, efektif membunuh bakteri dan jamur pada luka, mencegah infeksi berulang selama penyembuhan . Tujuan review paper ini untuk melaporkan hasil analisa penelitian yang berfokus pada pengaruh modern wound dressing terhadap bakteri Staphylococcus Aureus. Pencarian artikel yang relevan menggunakan database PubMed dan search engine Google dengan menggunakan kata kunci "modern wound dressing","antibacterial", "staphylococcus". Sepuluh artikel yang sesuai dengan kriteria inklusi dimasukkan dalam review paper ini. Modern wound dressing dengan kandungan antimikroba dapat menghambat pertumbuhan bakteri. Dengan demikian, review paper ini dapat menjadi dasar untuk penelitian selanjutnya tentang efektifitas modern wound dressing terhadap bakteri Staphylococcus Aureus.

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Section: Efektifitas Kandungan Modern Wound Dressing Terhadap Perkembunclassified

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Effectiveness of Modern Wound Dressing on the Growth of Staphylococcus Aureus Bacteria

Gito

Rochmawati

2018

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“…In this sense, colon targeting is naturally of value for the local and topical treatment of inflammatory bowel disease by means of the antibiotics target delivery systems [ 20 ]. In addition, it is well known that the extended oral administration of antibiotics can cause gastric-lesions during long periods [ 21 , 22 ], and a way to reduce it is by using clays which possess important bioadhesive properties, and gastroprotective antacid activity [ 23 ]. The resulting intercalation products can solve these problems by improving the drug properties and effectiveness, reducing its toxicity, and prolonging the half-lives in blood.…”

Section: Introductionmentioning

confidence: 99%

A simple way for targeted delivery of an antibiotic: In vitro evaluation of a nanoclay-based composite

et al. 2017

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The sodium-modified form of fluorohectorite nanoclay (NaFh) is introduced as a potential drug carrier, demonstrating its ability for the controlled release of the broad-spectrum antibiotic Ciprofloxacin through in vitro tests. The new clay-drug composite is designed to target the local infections in the large intestine, where it delivers most of the incorporated drug thanks to its pH-sensitive behavior. The composite has been conceived to avoid the use of coating technology and to decrease the side-effects commonly associated to the burst-release of the ciprofloxacin at the stomach level. NaFh was obtained from lithium-fluorohectorite by ion exchange, and its lack of toxicity was demonstrated by in vivo studies. Ciprofloxacin hydrochloride (Cipro) was encapsulated into the clay at different values of the pH, drug initial concentration, temperature and time. Systematic studies by X-ray diffraction (XRD), infrared and visible spectrophotometry (FT-IR and UV-vis), and thermal analysis (TGA) indicated that the NaFh host exhibits a high encapsulation efficiency for Cipro, which reaches a 90% of the initial Cipro in solution at 65 oC, with initial concentration of drug in solution of 1.36 x 10−2 mol L-1 at acid pH. XRD revealed that a true intercalation of Cipro takes place between clay layers. TG showed an increased thermal stability of the drug when intercalated into the clay, as compared to the “free” Cipro. IR suggested a strong clay-Cipro interaction via ketone group, as well as the establishment of hydrogen bonds between the two materials. In vitro drug release tests revealed that NaFh is a potentially efficient carrier to deliver Cipro in the large intestine, where the release process is mediated by more than just one mechanism.

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