Kefir Peptides Prevent Hyperlipidemia and Obesity in High‐Fat‐Diet‐Induced Obese Rats via Lipid Metabolism Modulation

Tung, Yu Tang; Chen, Hsiao Ling; Wu, Hsin Shan; Ho, Mei Hsuan; Chong, Kowit-Yu; Chen, Chuan-Mu

doi:10.1002/mnfr.201700505

Cited by 80 publications

(62 citation statements)

References 41 publications

(55 reference statements)

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“…Ebner et al (2015) and Dallas et al (2016) described the presence of peptides in kefir samples with biological activity, including antihypertensive, antimicrobial, immunomodulatory, opioid and antioxidative functions. Recent reports demonstrated that the administration of kefir or commercial peptides from kefir reduced weight gain in obese mice (Bourrie et al 2018;Tung et al 2018). Santanna et al (2017) showed that administration of nonmicrobial fraction caused a significant reduction in vascular lipid deposition.…”

Section: Metabolites Produced By Kefir Micro-organismmentioning

confidence: 99%

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Iraporda²,

et al. 2018

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Kefir is a homemade viscous and slightly effervescent beverage obtained by milk fermentation with kefir grains, which are built up by a complex community of lactic acid and acetic acid bacteria and yeasts confined in a matrix of proteins and polysaccharides. The present review summarizes the role of kefir micro-organisms in grain assembly and in the beneficial properties attributed to kefir. The use of both culture-dependent and independent methods has made possible to determine the micro-organisms that constitute this ecosystem. Kefir consumption has been associated with a wide range of functional and probiotic properties that could be attributed to the micro-organisms present in kefir and/or to the metabolites synthetized by them during milk fermentation. In this context, the role of micro-organisms in kefir health promoting properties is discussed with particular attention to the contribution of yeast as well as bioactive metabolites such as lactic and acetic acid, exopolysaccharides and bioactive peptides. Even though many advances on the knowledge of this ancient fermented milk have been made, further studies are necessary to elucidate the complex nature of the kefir ecosystem.

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Section: Metabolites Produced By Kefir Micro-organismmentioning

confidence: 99%

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Iraporda²,

et al. 2018

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“…Although the broiler liver is regarded as cheap and useless in the processing stream, it contains many nutrients, such as proteins and the trace minerals selenium (Se) and manganese (Mn) . Many reports have revealed bioactive hydrolysates with origins in food‐proteins . Our previous studies have also reported that pepsin‐digested chicken liver hydrolysates (CLHs) contain plenty of anserine (a dipeptide containing β ‐alanine and 1‐methylhistidine), taurine, branched‐chain amino acids (BCAAs) (i.e., isoleucine, leucine, and valine), and some anti‐oxidant amino acids (i.e., aspartic acid, glutamic acid, and histidine), which could enhance anti‐oxidative activity against chronic alcohol consumption and have an anti‐fibrotic effect .…”

Section: Introductionmentioning

confidence: 99%

“…8 Many reports have revealed bioactive hydrolysates with origins in foodproteins. 9,10 Our previous studies have also reported that pepsindigested chicken liver hydrolysates (CLHs) contain plenty of anserine (a dipeptide containing ⊎-alanine and 1-methylhistidine), taurine, branched-chain amino acids (BCAAs) (i.e., isoleucine, leucine, and valine), and some anti-oxidant amino acids (i.e., aspartic acid, glutamic acid, and histidine), which could enhance anti-oxidative activity against chronic alcohol consumption and have an antifibrotic effect. 8,11,12 The chicken is the best source among all meat sources of imidazole rings containing dipeptides (carnosine and anserine).…”

Section: Introductionmentioning

confidence: 99%

Cardiac protection of functional chicken‐liver hydrolysates on the high‐fat diet induced cardio‐renal damages via sustaining autophagy homeostasis

Lin

Huang

et al. 2020

J Sci Food Agric

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BACKGROUND Cardio‐renal syndrome (CRS) is an integrative problem related to chronic malnutrition, obesity, etc. Amino acids and peptides are regarded as protective and essential for tissues. Pepsin‐digested chicken liver hydrolysates (CLHs), which are made from the byproducts of the poultry industry, are amino‐acid based and of animal origin, and may be protective against the myocardial and renal damage induced by a high‐fat diet (HFD). RESULTS Our results showed that CLHs contain large quantities of anserine, taurine, and branched‐chain amino acids (BCAAs), and supplementing the diet with CLHs reduced (P < 0.05) weight gain, liver weight, peri‐renal fat mass / adipocyte‐area sizes, serum total cholesterol (TC), aspartate aminotransferase (AST), and low‐density lipoprotein cholesterol (LDLC) levels in HFD‐fed mice but increased (P < 0.05) serum high‐density lipoprotein cholesterol (HDLC) levels. By histological analyses, CLHs alleviated (P < 0.05) renal lipid deposition and fibrosis, as well as cardiac fibrosis and inflammation of HFD‐fed mice. Meanwhile, increased (P < 0.05) inflammatory and fibrotic cytokines levels in the myocardia of the HFD‐fed mice were downregulated (P < 0.05) by CLH supplementation. Regarding autophagy‐related protein levels, protective effects of CLHs on the myocardia against HFD feeding may result from the early blockade of the autophagy pathway to prevent autophagosome accumulation. CONCLUSION Functional CLHs could be a novel food ingredient as a cardio‐renal protective agent against a high‐fat dietary habit in a niche market. © 2020 Society of Chemical Industry

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“…En diferentes estudios se ha evidenciado que pacientes con desnutrición por exceso poseen una alta probabilidad de presentar hiperlipidemia. 7 La cardiopatía isquémica es más evidente con la presencia de la triada de factores de riesgo directo a la enfermedad coronaria, la cual está determinada por la obesidad, HTA y la DM. 8,9 Los eventos coronarios son la primera causa de muerte en el mundo y no es una estadística alejada de la que presenta Ecuador.…”

Section: Introductionunclassified

Comportamiento clínico epidemiológico del grupo de adultos mayores del Centro de Salud Tosagua, año 2016

2018

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Introducción: En la actualidad se ha incrementado de forma llamativa la esperanza de vida, se cuenta con mayor número de adultos mayores. Por lo que ha surgido la necesidad de crear un programa de atención integral de salud para este grupo etario.Objetivo: Describir el comportamiento clínico-epidemiológico del grupo de adultos mayores.Métodos: Se realizó un estudio observacional, descriptivo y retrospectivo en el Centro de Salud de Tosagua enclavado en la provincia Manabí de Ecuador en el periodo comprendido de enero a diciembre del año 2016.El universo estuvo integrado por las 285 personas que forman parte del grupo de adulto mayor de esa institución.Resultados: El 68% presentó menos de 70 años, un 73% correspondió al sexo femenino. Predominaron pacientes con hipertensión arterial con 62.5%. El pie diabético fue la complicación más frecuente con 1.8%. Los pacientes hipertensos mantuvieron compensación de la enfermedad durante todo el año, excepto en el mes de diciembre. Los que padecían de diabetes mellitus estuvieron descompensados durante todo el año. La metformina la utilizó el 80.4% de los diabéticos y el losartán estuvo en un 49.4% de hipertensos.Conclusiones: El grupo estudiado estuvo integrado mayormente por adultos mayores de menos de 70 años y predomino el sexo femenino. La hipertensión como entidad que principalmente presentaron los ancianos. Durante el periodo estudiado la mayoría de los hipertensos se mantuvieron compensados; sin embargo, la mayoría de los pacientes con diabetes mellitus estuvieron descompensados. El losartán es el antihipertensivo más utilizado. La metformina es el hipoglucemiante de mayor uso.

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Kefir Peptides Prevent Hyperlipidemia and Obesity in High‐Fat‐Diet‐Induced Obese Rats via Lipid Metabolism Modulation

Cited by 80 publications

References 41 publications

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Kefir micro-organisms: their role in grain assembly and health properties of fermented milk

Cardiac protection of functional chicken‐liver hydrolysates on the high‐fat diet induced cardio‐renal damages via sustaining autophagy homeostasis

Comportamiento clínico epidemiológico del grupo de adultos mayores del Centro de Salud Tosagua, año 2016

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