Keeping those telomeres short! an innovative intratumoral long-term drug delivery system

Laster, Zvi; Isaacson, Carol; Perets, Ekaterina; Msamra, M.; Priel, Esther; Kalef-Ezra, J.; Kost, Joseph

doi:10.1007/s00432-014-1747-7

Cited by 5 publications

(2 citation statements)

References 64 publications

(71 reference statements)

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“…An optimal drug delivery system should maintain the activity and stability of drug molecules through protecting them against degradation, prolonging circulation in vivo, targeting to the site to reduce toxicity to normal cells, controlling drug release, and freely eliminating out of the body. Researchers have developed a series of drug delivery systems, including natural systems like viruses, 10 collagen, and albumin, 11 synthetic polymer systems like liposomes, 12 poly-(lactic-co-glycolic) acid (PLGA), 13 polylactic acid (PLA), 14 oligo(p-phenylenevinylene) (OPV), 15 and poly(p-phenylenevinylene) (PPV), 16 and synthetic inorganic systems like nanocarbon materials 17 and gold nanoparticles. 18 These drug delivery systems increase the drug loading efficiency and minimize the side effects in normal cells.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembled Peptide Drug Delivery Systems

Yang

Wang

2020

ACS Appl. Bio Mater.

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Over the past several decades, rapid advances have been made in the application of nanomaterials in the biomedical field including bioimaging and drug delivery. Owing to the natural biocompatibility, diverse design, and dynamic self-assembly, peptides can be used as modules to construct self-assembled peptide-based nanomaterials, which have a high potential in reducing drug toxicity, improving drug targeting, and enhancing drug delivery efficiency. In this review, three typical design strategies of self-assembled peptide nanomaterials for drug delivery have been summarized including ex situ construction, in situ morphological transformation, and in situ construction of peptide drug delivery systems (PDDs). Drugs can be loaded to peptide nanomaterials by physical encapsulation or chemical conjugation methods, showing enhanced retention effects at tumor sites to increase the uptake rate of drugs. Interestingly, drug-free peptide nanomaterials also can be nanomedicines for delivery. These advances implicate the bright prospect of the self-assembled peptide in intelligent nanomedicine and clinical translation.

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Section: Introductionmentioning

confidence: 99%

Self-Assembled Peptide Drug Delivery Systems

Yang

Wang

2020

ACS Appl. Bio Mater.

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“…5 To overcome these constraints, researchers have focused on exploiting cytocompatible and resorbable biomaterials that possess better interaction with biological systems. 6 Preparation of synthetic polymers occurs in laboratories through chemical reaction; examples include poly(lactic-co-glycolic) acid (PLGA), 7 polylactic acid (PLA), 8 poly-ε-caprolactone (PCL), 8 etc. The challenging concerns such as biocompatibility, tunable biodegradability in relation with the neo-tissue formation after implantation, ease in processability, and controlling the porosity limit the utility of most of these synthetic polymers.…”

Section: Introductionmentioning

confidence: 99%

Insight into Silk-Based Biomaterials: From Physicochemical Attributes to Recent Biomedical Applications

Janani

Kumar

Chouhan

et al. 2019

ACS Appl. Bio Mater.

106

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Silk, a natural biopolymer, has been used clinically as suture material over thousands of years and has received much impetus for a plethora of biomedical applications in the last two decades. Silk protein isolated from both mulberry and nonmulberry silkworm varieties gained recognition as a potential biomaterial owing to its affordability and remarkable physicochemical properties. Molecular studies on the amino acid composition and conformation of silk proteins interpreted in the present review provide a critical understanding of the difference in crystallinity, hydrophobicity, and tensile strength among silkworm silk proteins. Meticulous silk fibroin (SF) isolation procedures and innovative processing techniques to fabricate gamut of two-dimensional (2D) and three-dimensional (3D) matrices including the latest 3D printed scaffolds have led SF for diverse biomedical applications. Crucial factors for clinical success of any biomaterial, including biocompatibility, immune response, and biodegradability, are discussed with particular emphasis on the lesser-known endemic nonmulberry silk varieties, which in recent years have gained considerable attention. The tunable biodegradation and bioresorbable attributes of SF enabled its use in drug delivery systems, thus proving it as an efficient and specific vehicle for controlled drug release and targeted drug delivery. Advancements in fabrication methodologies inspired biomedical researchers to develop SF-based in vitro tissue models mimicking the spatiotemporal arrangement and cellular distribution of native tissue. In vitro tissue models own a unique demand for studying tissue biology, cellular crosstalks, disease modeling, drug designing, and high throughput drug screening applications. Significant progress in silk biomaterial research has evolved into several silk-based healthcare products in the market. Insights of silk-based products assessed in the human clinical trials are presented in this review. Overall, the current review explores the paradigm of the silk structure–function relationship driving silk-based biomaterials toward tissue engineering, drug delivery systems, and in vitro tissue models.

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From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly

Liu,

Wang

2024

Advanced Drug Delivery Reviews

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Keeping those telomeres short! an innovative intratumoral long-term drug delivery system

Cited by 5 publications

References 64 publications

Self-Assembled Peptide Drug Delivery Systems

Self-Assembled Peptide Drug Delivery Systems

Insight into Silk-Based Biomaterials: From Physicochemical Attributes to Recent Biomedical Applications

From cells to subcellular organelles: Next-generation cancer therapy based on peptide self-assembly

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