Keeping the CNS clear: Glial phagocytic functions in <i>Drosophila</i>

Kurant, Estee

doi:10.1002/glia.21098

Cited by 45 publications

(38 citation statements)

References 100 publications

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“…For example, in Drosophila, glial cells, albeit not microglia, engulf dead cell corpses and axons through a Draper/dCED-6-dependent signaling pathway, a pathway previously found in Caenorhabditis elegans (Zhou et al 2001). In addition, microglia engulf apoptotic neurons in developing zebrafish via another pathway, the v0-ATPase a1 subunit (Logan and Freeman 2007;Peri and NussleinVolhard 2008;Kurant 2011;. It remains to be determined whether the same or similar mechanisms are involved in PCD in the mammalian CNS.…”

Section: Regulation Of Cell Deathmentioning

confidence: 99%

Microglia Function in Central Nervous System Development and Plasticity

Schafer

Stevens

2015

Cold Spring Harb Perspect Biol

300

259

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The nervous system comprises a remarkably diverse and complex network of different cell types, which must communicate with one another with speed, reliability, and precision. Thus, the developmental patterning and maintenance of these cell populations and their connections with one another pose a rather formidable task. Emerging data implicate microglia, the resident myeloid-derived cells of the central nervous system (CNS), in the spatial patterning and synaptic wiring throughout the healthy, developing, and adult CNS. Importantly, new tools to specifically manipulate microglia function have revealed that these cellular functions translate, on a systems level, to effects on overall behavior. In this review, we give a historical perspective of work to identify microglia function in the healthy CNS and highlight exciting new work in the field that has identified roles for these cells in CNS development, maintenance, and plasticity.

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Section: Regulation Of Cell Deathmentioning

confidence: 99%

Microglia Function in Central Nervous System Development and Plasticity

Schafer

Stevens

2015

Cold Spring Harb Perspect Biol

300

259

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“…72 Hemocytes also phagocyte dead bodies and debris, much like glial cells, which do so during metamorphosis, when the nervous system has to be reshaped, and upon injury. 73 Thus, the Glide/ Gcm pathway is shared by the 2 macrophagic cell populations ( Fig. 5A and B).…”

Section: Glia and Bloodmentioning

confidence: 88%

Lineage specification in the fly nervous system and evolutionary implications

Cattenoz¹,

Giangrande²

2013

Cell Cycle

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“…Since glial cells are the main cleaners of the central nervous system (CNS), and function through engulfment and degradation of dying neurons and degenerating neuronal branches in Drosophila, 43) the increased glial cell number in Aβ42-expressing larval brains could be a result of neuronal apoptosis. To test this, we counted the number of glial cells in the brain of larvae co-expressing Aβ42 and Drosophila inhibitor of apoptosis protein 1 (DIAP1).…”

Section: S T-test; N≥20) the Genotypes Of The Samples Are Elav-gal4 mentioning

confidence: 99%

Suppressive Effects of SuHeXiang Wan on Amyloid-β42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic <i>Drosophila</i> Model of Alzheimer’s Disease

Park

Lee

Hong

et al. 2013

Biological & Pharmaceutical Bulletin

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SuHeXiang Wan (SHXW), a Chinese traditional medicine, has been used to treat infantile convulsions, seizures and strokes. Previously, we reported that modified SHXW, called KSOP1009, suppressed the hyperactivation of c-Jun N-terminal kinase (JNK) and Alzheimer's disease (AD)-like phenotypes in amyloid-β42 (Aβ42)-expressing Drosophila AD models. In the present study, we, further, investigated the detailed mechanism by which KSOP1009 suppresses the AD-like phenotypes of the model flies. As seen in the brains of AD patients, pan-neuronal expression of Aβ42 in Drosophila increased activation of extracellular signal-regulated kinase (ERK), which was monitored by its phosphorylation level, and the number of glial cells in the brain. Suppression of caspase activity did not affect these phenomena, suggesting that Aβ42 induces ERK activation and glial cell proliferation independently of apoptotic processes. KSOP1009 intake significantly reduced the level of ERK activation and the number of glial cells. Moreover, KSOP1009 intake also effectively decreased the defects in the wing vein formation induced by Epidermal growth factor receptor (Egfr) overexpression in fly wings, suggesting that it may contain an inhibitory substance that inhibits the EGFR/ERK signaling pathway. In addition, the Aβ42-induced locomotive defect was partially rescued by inhibition of the elevated ERK activity through its antagonistic drug treatment. Taken together, these results suggest that KSOP1009 exerts its therapeutic effect by inhibiting the EGFR/ERK pathway and glial cell proliferation and by suppressing the JNK pathway and apoptosis.

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Keeping the CNS clear: Glial phagocytic functions in Drosophila

Cited by 45 publications

References 100 publications

Microglia Function in Central Nervous System Development and Plasticity

Microglia Function in Central Nervous System Development and Plasticity

Lineage specification in the fly nervous system and evolutionary implications

Suppressive Effects of SuHeXiang Wan on Amyloid-β42-Induced Extracellular Signal-Regulated Kinase Hyperactivation and Glial Cell Proliferation in a Transgenic <i>Drosophila</i> Model of Alzheimer’s Disease

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