Keeping tabs on fructose

Shalev, Anath

doi:10.7554/elife.21263

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Excessive consumption of these sweeteners has been closely linked to increased risk of NAFLD. 47 Hence, sucrose or HFCS were used singly or combined with high fat in the diet to mimic human dietary style. Although the treatments of dosage, routing, and intervention time varied among these studies, green tea and its components could significantly improve blood biochemical profiles and liver histological parameters and alleviate liver lipids accumulation in different degrees when compared with the control group.…”

Section: ■ Mechanisms and Pathogenesis Of Nafldmentioning

confidence: 99%

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Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

Zhou¹,

Long³

et al. 2019

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD) is a typical chronic liver disease highly correlated with metabolic syndrome. Growing prevalence of NAFLD is supposed to be linked with the unhealthy lifestyle, especially high-calorie diet and lacking enough exercise. Currently, there is no validated pharmacological therapy for NAFLD except for weight reduction. However, many dietary strategies had preventive effects on the development of liver steatosis or its progression. As one of the most common beverages, green tea contains abundant bioactive compounds possessing antioxidant, lipid-lowering, and anti-inflammatory effects, as well as improving insulin resistance and gut dysbiosis that can alleviate the risk of NAFLD. Hence, in this review, we summarized the studies of green tea and its components on NAFLD from animal experiments and human interventions and discussed the potential mechanisms. Available evidence suggested that tea consumption is promising to prevent NAFLD, and further mechanisms and clinical studies need to be investigated.

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Section: ■ Mechanisms and Pathogenesis Of Nafldmentioning

confidence: 99%

“…Sucrose and HFCS are important ingredients in the modern Western diet. Excessive consumption of these sweeteners has been closely linked to increased risk of NAFLD . Hence, sucrose or HFCS were used singly or combined with high fat in the diet to mimic human dietary style.…”

Section: Potential Preventive Mechanisms Of Green Tea and Its Compone...mentioning

confidence: 99%

Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

Zhou¹,

Long³

et al. 2019

J. Agric. Food Chem.

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“…Recently, some groups reported that there was an indirect pathway mediated by thioredoxin-interacting protein (TXNIP) [ 56 , 57 ]. TXNIP plays an important role in regulating intracellular redox state [ 58 ].…”

Section: Chrebp Regulates Glycolysis and Fructolysis Through Altermentioning

confidence: 99%

The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism

Iizuka

2017

Nutrients

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Many articles have discussed the relationship between fructose consumption and the incidence of obesity and related diseases. Fructose is absorbed in the intestine and metabolized in the liver to glucose, lactate, glycogen, and, to a lesser extent, lipids. Unabsorbed fructose causes bacterial fermentation, resulting in irritable bowl syndrome. Therefore, understanding the mechanisms underlying intestinal and hepatic fructose metabolism is important for the treatment of metabolic syndrome and fructose malabsorption. Carbohydrate response element binding protein (ChREBP) is a glucose-activated transcription factor that controls approximately 50% of de novo lipogenesis in the liver. ChREBP target genes are involved in glycolysis (Glut2, liver pyruvate kinase), fructolysis (Glut5, ketohexokinase), and lipogenesis (acetyl CoA carboxylase, fatty acid synthase). ChREBP gene deletion protects against high sucrose diet-induced and leptin-deficient obesity, because Chrebp−/− mice cannot consume fructose or sucrose. Moreover, ChREBP contributes to some of the physiological effects of fructose on sweet taste preference and glucose production through regulation of ChREBP target genes, such as fibroblast growth factor-21 and glucose-6-phosphatase catalytic subunits. Thus, ChREBP might play roles in fructose metabolism. Restriction of excess fructose intake will be beneficial for preventing not only metabolic syndrome but also irritable bowl syndrome.

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“…Even more appealing, many of these engines are free to access. Indeed, game engines have been successfully used to build custom VE experiment tasks (examples include: Deuker et al, 2016;Starrett et al, 2019;Tsitsiklis et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

OpenMaze: An Open-Source Toolbox for Creating Virtual Navigation Experiments

Alsbury-Nealy¹,

Wang²,

Howarth³

et al. 2020

Preprint

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Incorporating 3D virtual environments into psychological experiments offers an innovative solution for balancing experimental control and ecological validity. Their flexible use, however, has been limited to those researchers with extensive coding experience because the field lacks accessible development tools. We created OpenMaze, an open-source toolbox for the Unity game engine, to overcome this barrier. OpenMaze offers researchers the ability to conduct a wide range of 3D spatial navigation experiment paradigms in fully customized 3D environments. Crucially, because all experiment configurations are defined in user-friendly JavaScript Object Notation (JSON) files, our toolbox allows even those with no prior coding experience to build bespoke tasks. OpenMaze is also compatible with a variety of input devices and operating systems, broadening its possible applications. To demonstrate its advantages, we review and contrast other available software options before guiding the reader through building an experiment in OpenMaze.

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Keeping tabs on fructose

Abstract: Too much fructose in the diet can worsen metabolic problems via a process that involves thioredoxin-interacting protein.

Cited by 3 publications

References 16 publications

Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

Preventive Efficiency of Green Tea and Its Components on Nonalcoholic Fatty Liver Disease

The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism

OpenMaze: An Open-Source Toolbox for Creating Virtual Navigation Experiments

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