Isopleths and solution densities are reported, from ≈ 25 to 100 °C and pressures to ≈ 200 bar, for mixtures of CO 2 with pyrazine, 2-methoxypyrazine, 2-acetylpyrazine, 2-methylpyrazine, and 2,3-dimethylpyrazine. These five solute + CO 2 systems exhibit type-I phase behavior with similar mixture critical pressures up to 100 °C. The Peng-Robinson equation of state, with k ij equal to zero, provides a semi-quantitative representation of the data for all of the pyrazines with the exception of the 2-acetylpyrazine + CO 2 system, which required a k ij of -0.100 to get a reasonable representation of the data. The data presented here further substantiates the observation that supercritical CO 2 can be used to extract pyrazines from natural materials.