Keeping It Organized: Multicompartment Constructs to Mimic Tissue Heterogeneity (Adv. Healthcare Mater. 17/2023)

Abstract

Tissue Engineering When engineering tissues in vitro it is essential to mimic the heterogeneity present in native tissues, both in composition and biological components. While different approaches and manufacturing technologies are used in literature, bioprinting holds great promise, being able to recapitulate complex architectural 3D features and use bioinks to support biological requirements. These considerations are reviewed in article 2202110 by Manuel Salmeron‐Sanchez.

Functionalising silk hydrogels with hetero- and homotypic nanoparticles

“… 4 This microenvironment potentially includes many different cell types and biomaterials that serve as tissue scaffolds. 5 These scaffolds not only provide structural support but can also regulate function, including cell–cell communication, tissue homeostasis and immune cell responses (reviewed in ref. 5 and 6 ).…”

“… 5 These scaffolds not only provide structural support but can also regulate function, including cell–cell communication, tissue homeostasis and immune cell responses (reviewed in ref. 5 and 6 ). Therefore, biomaterials are critical enablers of a broad spectrum of tissue engineering applications in both health and disease.…”