“…The results of the two RCTs that evaluated the kiR version directed at 5th-grade students showed that the program does not seem to be effective in reducing drug use by students 8,10,20 . On the other hand, except for the Brazilian study (PROERD/Caindo na Real), the results of other RCTs (n=8) that evaluated the curriculum for 7 th -8 th -grade students, in the different versions (Mexican/Mexican American, Black/White, multicultural, kiR-Plus, kiR-AE, Mantente Real, Living in 2 Worlds, and kiR for rural areas) showed a positive effect on reducing episodes of alcohol intoxication 33 , use of alcohol 25,26,28,29,31,33 , cigarettes [22][23][24]28,31 , marijuana 22,25,26,28,29 , and other illicit drugs in the last 30 days 26,27 . Positive results of the 7th-grade curriculum were also evidenced among those young people who, before starting the intervention, already reported using alcohol and/or other drugs 27,32,33 , as well as among those who presented risky behaviors 26 .…”