Keep Your Friends Close: Cell–Cell Contact and Skeletal Myogenesis

Krauss, Robert M.; Joseph, Giselle A.; Goel, Aviva

doi:10.1101/cshperspect.a029298

Cited by 51 publications

(39 citation statements)

References 107 publications

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“…4c). Cell movement such as migration, adhesion, and fusion is dependent on cell-cell communication, in which extracellular matrix and membrane-associated proteins play vital roles, is also important in skeletal muscle development [1,14]. These results might provide clues to find target genes for Zfp422.…”

Section: Zfp422 Influences the Expression Of Myogenic Genesmentioning

confidence: 96%

“…Skeletal muscle is the most abundant and highly complex tissue in a normal vertebrate body. The process of vertebrate skeletal muscle development includes the proliferation, cell cycle withdrawal, differentiation, fusion, and elongation into multinucleated myofibers of myogenic precursor cells or myoblasts [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, there are many nontranscription factors playing important roles in regulating cell-cell contact between myoblasts and its surrounding cells [1,14]. Cell-cell contact, such as cell adhesion, migration [15,16], and fusion [17], is also vital in skeletal muscle development.…”

Section: Introductionmentioning

confidence: 99%

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Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis

et al. 2019

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Zinc finger protein 422 (Zfp422) is a widely expressed zinc finger protein that serves as a transcriptional factor to regulate downstream gene expression, but until now, little is known about its roles in myogenesis. We found here that Zfp422 plays a critical role in skeletal muscle development and regeneration. It highly expresses in mouse skeletal muscle during embryonic development. Specific knockout of Zfp422 in skeletal muscle impaired embryonic muscle formation. Satellite cell-specific Zfp422 deletion severely inhibited muscle regeneration. Myoblast differentiation and myotube formation were suppressed in Zfp422-deleted C2C12 cells, isolated primary myoblasts, and satellite cells. Chromatin Immunoprecipitation Sequencing (ChIP-Seq) revealed that Zfp422 regulated ephrin type-A receptor 7 (EphA7) expression by binding an upstream 169-bp DNA sequence, which was proved to be an enhancer of EphA7. Knocking EphA7 down in C2C12 cells or deleting Zfp422 in myoblasts will inhibit cell apoptosis which is required for myoblast differentiation. These results indicate that Zfp422 is essential for skeletal muscle differentiation and fusion, through regulating EphA7 expression to maintain proper apoptosis.

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Section: Zfp422 Influences the Expression Of Myogenic Genesmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis

et al. 2019

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“…1,2 The growth and development of skeletal muscle affect life activities, and patients with many pathological conditions show abnormal muscle development, such as immobilization after fracture, Duchenne muscular dystrophy (DMD) and Facioscapulohumeral muscular dystrophy. 9 It is a multistep process regulated by multiple myogenic regulatory factors, including myoblast regulatory factor family myogenic factor (Myf)-5, myogenic differentiation antigen (MyoD), myogenin (MyoG), myogenic regulatory factor-4 (MRF-4), myocyte enhancer factor2A-D (MEF2A-2D), myosin heavy chain (Myh) and paired box (Pax) family members Pax 3 and Pax 7. 9 It is a multistep process regulated by multiple myogenic regulatory factors, including myoblast regulatory factor family myogenic factor (Myf)-5, myogenic differentiation antigen (MyoD), myogenin (MyoG), myogenic regulatory factor-4 (MRF-4), myocyte enhancer factor2A-D (MEF2A-2D), myosin heavy chain (Myh) and paired box (Pax) family members Pax 3 and Pax 7.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5][6][7][8] The formation of skeletal muscle is known as myogenesis and requires the fusion of myoblasts to produce multinucleated fibres. 9 It is a multistep process regulated by multiple myogenic regulatory factors, including myoblast regulatory factor family myogenic factor (Myf)-5, myogenic differentiation antigen (MyoD), myogenin (MyoG), myogenic regulatory factor-4 (MRF-4), myocyte enhancer factor2A-D (MEF2A-2D), myosin heavy chain (Myh) and paired box (Pax) family members Pax 3 and Pax 7.…”

Section: Introductionmentioning

confidence: 99%

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

et al. 2019

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The multistep biological process of myogenesis is regulated by a variety of myoblast regulators, such as myogenic differentiation antigen, myogenin, myogenic regulatory factor, myocyte enhancer factor2A-D and myosin heavy chain. Proliferation and differentiation during skeletal muscle myogenesis contribute to the physiological function of muscles. Certain non-coding RNAs, including long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in the regulation of muscle development, and the aberrant expressions of lncRNAs and circRNAs are associated with muscular diseases. In this review, we summarize the recent advances concerning the roles of lncRNAs and circRNAs in regulating the developmental aspects of myogenesis. These findings have remarkably broadened our understanding of the gene regulation mechanisms governing muscle proliferation and differentiation, which makes it more feasible to design novel preventive, diagnostic and therapeutic strategies for muscle disorders. K E Y W O R D ScircRNAs, development, differentiation, lncRNAs, proliferation, skeletal muscle

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Continuous Production of Acoustically Patterned Cells Within Hydrogel Fibers for Musculoskeletal Tissue Engineering

Deshmukh

Reichert

Zvick

et al. 2022

Adv Funct Materials

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Many mammalian tissues have a specific cellular arrangement that enables their unique function. For example, parallel alignment of myofibers enables uniaxial muscle contraction. To engineer structured tissues ex vivo, it is critical to recapitulate this cellular arrangement. Conventional 3D encapsulation often fails to recapitulate this complexity, motivating the need for advanced patterning approaches. In this work, an acoustofluidic device to continuously pattern mammalian cells within hydrogel fibers is engineered. Contactless acoustofluidic forces are used to control the spacing between parallel lines of cells. To enable continuous extrusion of cell-laden hydrogel fibers, a low friction Teflon tube is integrated into the device. A photopolymerizable hydrogel allows triggering gelation externally with light once the cells are under the influence of the acoustic field, setting the patterned cells within the hydrogel fiber. Using this device, the muscle progenitor cells (myoblasts) within the hydrogel are patterned in parallel lines to mimic the structure of skeletal muscle. The increased formation of myotubes and spontaneous twitching of the myotubes in patterned samples are observed. This approach combining continuous fabrication with the tunability of acoustofluidics can create complex 3D tissues to engineer skeletal muscles as well as tendons, ligaments, vascular networks, or combinations thereof in the future.

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Keep Your Friends Close: Cell–Cell Contact and Skeletal Myogenesis

Cited by 51 publications

References 107 publications

Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis

Zfp422 promotes skeletal muscle differentiation by regulating EphA7 to induce appropriate myoblast apoptosis

Roles of lncRNAs and circRNAs in regulating skeletal muscle development

Continuous Production of Acoustically Patterned Cells Within Hydrogel Fibers for Musculoskeletal Tissue Engineering

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