Keep off the grass: marijuana use and acute cardiovascular events

Caldicott, David; Holmes, James F.; Roberts‐Thomson, Kurt C.; Mahar, L. J.

doi:10.1097/00063110-200510000-00008

Cited by 71 publications

(51 citation statements)

References 62 publications

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“…41 On the contrary, occasional myocardial infarction after acute assumption of cannabis has been reported in humans. 42 It is noteworthy that, marijuana smoking by people with either silent or overt cardiovascular disease poses health risks because of the consequences of the resulting increased cardiac work, increased catecholamine levels, carboxyhemoglobin and postural hypotension. 43 Hence, we can hypothesize that in our young healthy subjects with no cardiovascular risk factors, prolonged cannabis use might have acted as a secretagogue on the endocrine pancreas, thus inducing insulin resistance, endothelial dysfunction and different degrees of ED.…”

Section: Endothelial Dysfunction In Erectile Dysfunction a Aversa Et Almentioning

confidence: 99%

Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users

et al. 2008

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Aim of the study was to evaluate whether endothelial dysfunction is a marker of erectile dysfunction (ED) in recreational drug abuse. Sixty-four non-consecutive men complaining of ED from at least 3 months were included. All patients underwent detailed history about recreational drug abuse and were then submitted to dynamic penile duplex ultrasound (PDU). According to pharmaco-stimulated peak systolic velocity (PSV) cutoff at 35 cm s À1 , patients were divided into two groups: organic (O; n ¼ 30) and non-organic (NO; n ¼ 34) ED. All subjects and 7 healthy age-matched subjects as controls, underwent veno-occlusive plethysmography (VOP) for the evaluation of endothelium-dependent dilatation of brachial arteries. Blood pressure, total and free testosterone, prolactin, estradiol, low-density lipoprotein and high-density lipoprotein cholesterol were also evaluated; patients were classified with regard to insulin resistance through the HOMA-IR index. Cannabis smoking was more frequent in O-ED vs NO-ED (78% vs 3%, Po0.001) in the absence of any concomitant risk factor or comorbidity for ED. VOP studies revealed impaired endotheliumdependent vasodilatation in O-ED but not in NO-ED and controls (12±6 vs 32±4 and 34 ± 5 ml min À1 , respectively; P ¼ 0.003). Overall patients showed a direct relationship between HOMA-IR and PSV (r 2 ¼ 0.47, Po0.0001), which was maintained in men with organic ED (r 2 ¼ 0.62, Po0.0001). In cannabis consumers, a direct relationship between HOMA-IR and VOP was also found (r 2 ¼ 0.74, Po0.0001). Receiver-operating characteristic (ROC) curve analysis revealed that VOP values below 17.22 ml min À1 were suggestive for vasculogenic ED. We conclude that early endothelial damage may be induced by chronic cannabis use (and endocannabinoid system activation); insulin resistance may be the hallmark of early endothelial dysfunction and may concur to determine vascular ED in the absence of obesity. Further studies are warranted to establish a direct relationship between cannabis abuse, onset of insulin resistance and development of vascular ED.

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Section: Endothelial Dysfunction In Erectile Dysfunction a Aversa Et Almentioning

confidence: 99%

Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users

et al. 2008

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“…Although marijuana is known to contain over sixty chemical entities, the major pharmacologically active compound is delta 9 tetrahydrocannabinol (THC) [3]. The THC content in marijuana is variable, depending on strain and growth conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The THC content in marijuana is variable, depending on strain and growth conditions. The biological effects of cannabinoids are mediated through endogenous cannabinoid receptors which are found in a variety of tissues including the brain, heart and blood vessels [3]. Cannabis is rapidly absorbed through the lungs during cannabis smoking.…”

Section: Discussionmentioning

confidence: 99%

“…There are comprehensive reviews and case reports that reveal that cannabis is a trigger of adverse cardiovascular events including AMI [3][4][5]. The potential mechanisms of coronary thrombosis associated with cannabis use are vasospasm, sluggish coronary flow, endothelial dysfunction by reduced availability of nitric oxide, necrotizing angiitis leading to thromboembolism, activation of platelets by enhancing expression of glycoprotein IIb-IIIa and P-selectin on platelet surface in a concentration-dependent manner, activation of factor VII, and nonreversible platelet aggregation with higher concentrations of cannabis metabolites [3][4][5][6]. It is reported that risk of developing an AMI is 4.8 times higher within the first hour following cannabis use [7].…”

Section: Discussionmentioning

confidence: 99%

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Cannabis joint triggered recurrent anterior myocardial infarction in an adolescent taking dual anti-platelet therapy

Bıyık¹,

Aktürk²,

Yalçın³

et al. 2012

pwki

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A b s t r a c tCannabis smoking has been rising world-wide especially in industrialized western countries. It has been known that cannabis use has adverse effects on the heart and vascular system and an increased risk of acute myocardial infarction (AMI) has been reported. The actual mechanism of cannabis-related AMI is not well known. In this report, we describe an adolescent with cannabis-induced recurrent left anterior descending coronary artery thrombosis and anterior myocardial infarction even on dual anti-platelet therapy.K Ke ey y w wo or rd ds s: : cannabis, marijuana, recurrent myocardial infarction, dual anti-platelet therapy S t r e s z c z e n i ePalenie konopi indyjskich rozpowszechnia się zwłaszcza w uprzemysłowionych krajach zachodnich. Udowodniono, że negatywnie wpływa ono na serce i układ naczyniowy oraz zwiększa ryzyko wystąpienia ostrego zawału serca. Dokładny mechanizm zawału serca wywołanego przez konopie indyjskie nie jest znany. Przedstawiamy przypadek młodego pacjenta z nawrotem zakrzepicy w gałęzi przedniej zstępującej i ostrym zawałem serca, mimo stosowania podwójnej terapii przeciwpłytkowej. S Sł ło ow wa a k kl lu uc cz zo ow we e: : konopie indyjskie, marihuana, nawrót zawału serca, podwójna terapia przeciwpłytkowa

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“…The pathophysiological effects of cannabis smoking and its relation to adverse cardiovascular events have been previously reported (1,2). Sildenafil citrate is widely used as a primary pharmacological treatment of erectile dysfunction in men with and without underlying cardiovascular disease (3).…”

Section: Introductionmentioning

confidence: 99%

Cannabis smoking and sildenafil citrate induced acute coronary syndrome in a patient with myocardial bridge

Lee¹,

Song²,

Kang³

et al. 2012

Anadolu Kardiyol Derg

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Keep off the grass: marijuana use and acute cardiovascular events

Cited by 71 publications

References 62 publications

Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users

Early endothelial dysfunction as a marker of vasculogenic erectile dysfunction in young habitual cannabis users

Cannabis joint triggered recurrent anterior myocardial infarction in an adolescent taking dual anti-platelet therapy

Cannabis smoking and sildenafil citrate induced acute coronary syndrome in a patient with myocardial bridge

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