Keep calm and reboot – how cells restart transcription after DNA damage and DNA repair
Lise‐Marie Donnio,
Giuseppina Giglia‐Mari
Abstract:The effects of genotoxic agents on DNA and the processes involved in their removal have been thoroughly studied; however, very little is known about the mechanisms governing the reinstatement of cellular activities after DNA repair, despite restoration of the damage‐induced block of transcription being essential for cell survival. In addition to impeding transcription, DNA lesions have the potential to disrupt the precise positioning of chromatin domains within the nucleus and alter the meticulously organized … Show more
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