KDAS, a new blood group antigen in the Knops blood group system antithetical to KCAM

Scharberg, Erwin A.; Rink, Gabi; Schulz, Daniela; Rothenberger, Sina; Stürtzel, Annette; Gillhuber, Nicole; Seyboth, Susanne; Bugert, Peter

doi:10.1111/trf.15938

Cited by 2 publications

(4 citation statements)

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“…Knops is encoded by the complement receptor type 1 gene ( CR1 ) on chromosome 1q32.2. The reference allele KN*01 encodes the common antigens Kn(a+), McC(a), Sl1+, Sl3+, KCAM, and DACY+ [ 36 ]. Our results showed 15 participants homozygous for KN*01.-05 / KN*01.-05 , which predicts a loss of the high incidence antigen Yka.…”

Section: Discussionmentioning

confidence: 99%

Genetic Characterization of Blood Group Antigens for Polynesian Heritage Norfolk Island Residents

O’Brien,

Lea,

Jadhao

et al. 2023

Genes

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Improvements in blood group genotyping methods have allowed large scale population-based blood group genetics studies, facilitating the discovery of rare blood group antigens. Norfolk Island, an external and isolated territory of Australia, is one example of an underrepresented segment of the broader Australian population. Our study utilized whole genome sequencing data to characterize 43 blood group systems in 108 Norfolk Island residents. Blood group genotypes and phenotypes across the 43 systems were predicted using RBCeq. Predicted frequencies were compared to data available from the 1000G project. Additional copy number variation analysis was performed, investigating deletions outside of RHCE, RHD, and MNS systems. Examination of the ABO blood group system predicted a higher distribution of group A1 (45.37%) compared to group O (35.19%) in residents of the Norfolk Island group, similar to the distribution within European populations (42.94% and 38.97%, respectively). Examination of the Kidd blood group system demonstrated an increased prevalence of variants encoding the weakened Kidd phenotype at a combined prevalence of 12.04%, which is higher than that of the European population (5.96%) but lower than other populations in 1000G. Copy number variation analysis showed deletions within the Chido/Rodgers and ABO blood group systems. This study is the first step towards understanding blood group genotype and antigen distribution on Norfolk Island.

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Section: Discussionmentioning

confidence: 99%

Genetic Characterization of Blood Group Antigens for Polynesian Heritage Norfolk Island Residents

O’Brien,

Lea,

Jadhao

et al. 2023

Genes

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show abstract

“…The CR1 gene encodes the glycoprotein that carries the Knops antigens, and loss of the KCAM antigen is known to arise from CR1 c.4843A>G change, which results in p.Ile1615Val. Additional testing showed this patient's antibody to be non‐reactive with KCAM+ cells from 23 individuals homozygous CR1 c.4843A but reactive with KCAM+ cells from individuals heterozygous CR1 c.4843A/G and with KCAM− cells from individuals homozygous CR1 c.4843G [35].…”

Section: New Blood Group Antigens In Existing Blood Group Systemsmentioning

confidence: 99%

“…Three new antigens complete two new antithetic relationships of the Knops (KN) blood group system, KCAM/KDAS and DACY/YCAD, respectively [1,[34][35][36].…”

Section: New Blood Group Antigens In Existing Blood Group Systemsmentioning

confidence: 99%

“…gens, and loss of the KCAM antigen is known to arise from CR1 c.4843A>G change, which results in p.Ile1615Val. Additional testing showed this patient's antibody to be non-reactive with KCAM+ cells from 23 individuals homozygous CR1 c.4843A but reactive with KCAM+ cells from individuals heterozygous CR1 c.4843A/G and with KCAMÀ cells from individuals homozygous CR1 c.4843G[35].KCAM is defined by p.Ile1615, and the antithetical antigen to KCAM was named KDAS and is defined by the amino acid change from isoleucine (KCAM) to valine (KDAS). The antigen name KDAS (ISBT 022010) was derived from the name of the proband.…”

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confidence: 99%

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International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems

et al. 2022

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Background and Objectives Under the ISBT, the Working Party (WP) for Red Cell Immunogenetics and Blood Group Terminology is charged with ratifying blood group systems, antigens and alleles. This report presents the outcomes from four WP business meetings, one located in Basel in 2019 and three held as virtual meetings during the COVID‐19 pandemic in 2020 and 2021. Materials and Methods As in previous meetings, matters pertaining to blood group antigen nomenclature were discussed. New blood group systems and antigens were approved and named according to the serologic, genetic, biochemical and cell biological evidence presented. Results Seven new blood group systems, KANNO (defined numerically as ISBT 037), SID (038), CTL2 (039), PEL (040), MAM (041), EMM (042) and ABCC1 (043) were ratified. Two (039 and 043) were de novo discoveries, and the remainder comprised reported antigens where the causal genes were previously unknown. A further 15 blood group antigens were added to the existing blood group systems: MNS (002), RH (004), LU (005), DI (010), SC (013), GE (020), KN (022), JMH (026) and RHAG (030). Conclusion The ISBT now recognizes 378 antigens, of which 345 are clustered within 43 blood group systems while 33 still have an unknown genetic basis. The ongoing discovery of new blood group systems and antigens underscores the diverse and complex biology of the red cell membrane. The WP continues to update the blood group antigen tables and the allele nomenclature tables. These can be found on the ISBT website (http://www.isbtweb.org/working-parties/red-cell-immunogenetics-and-blood-group-terminology/).

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KDAS, a new blood group antigen in the Knops blood group system antithetical to KCAM

Cited by 2 publications

References 3 publications

Genetic Characterization of Blood Group Antigens for Polynesian Heritage Norfolk Island Residents

Genetic Characterization of Blood Group Antigens for Polynesian Heritage Norfolk Island Residents

International Society of Blood Transfusion Working Party on Red Cell Immunogenetics and Blood Group Terminology Report of Basel and three virtual business meetings: Update on blood group systems

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