KCNQ1OT1 facilitates progression of non‐small‐cell lung carcinoma via modulating miRNA‐27b‐3p/HSP90AA1 axis

Dong, Zhiwu; Yang, Ping; Qiu, Xiaojian; Liang, Shuang; Guan, Bing; Yang, Haisheng; Li, Feifei; Sun, Li; Liu, Huiling; Guang-Hui, Zou; Zhao, Ke-Wen

doi:10.1002/jcp.27788

Cited by 67 publications

(43 citation statements)

References 43 publications

(55 reference statements)

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“…Emerging evidence have shown that lncRNAs, including KCNQ1OT1, may act as competing endogenous RNA to regulate the expression of tumor‐associated genes. For example, KCNQ1OT1 promotes the progression of non–small cell lung cancer (NSCLC) through upregulating HSP90AA1 by sponging miR‐27b . In tongue cancer, it also has been reported KCNQ1OT1 directly interacts with miR‐211‐5p to facilitate cell proliferation and cisplatin resistance .…”

Section: Discussionmentioning

confidence: 99%

“…For example, KCNQ1OT1 promotes the progression of non-small cell lung cancer (NSCLC) through upregulating HSP90AA1 by sponging miR-27b. 32 In tongue cancer, it also has been reported KCNQ1OT1 directly interacts with miR-211-5p to facilitate cell proliferation and cisplatin resistance. 33 Therefore, we hypothesized that the function of KCNQ1OT1 in MSSCC was also in part mediated by miRNAs.…”

Section: Discussionmentioning

confidence: 99%

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Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR‐204/EphA7 axis

Sun

et al. 2019

J of Cellular Biochemistry

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Long noncoding RNAs have been demonstrated to contribute to the development and progression of various cancers. However, the underlying regulatory mechanisms of KCNQ1OT1 in tumorigenesis of maxillary sinus squamous cell carcinoma (MSSCC) remain unknown. Herein, we found that KCNQ1OT1 expression was markedly upregulated in MSSCC tissues and MSSCC cell line (IMC‐3) by using quantitative reverse transcription‐polymerase chain reaction. Loss‐of‐function experiments revealed that the deletion of KCNQ1OT1 inhibited cell proliferation, migration, and invasion. Moreover, we confirmed KCNQ1OT1 could directly interact with miR‐204 by bioinformatic prediction and dual luciferase assay, and miR‐204 inhibitor markedly reversed MSSCC tumor phenotypes induced by shKCNQ1OT1. Finally, we demonstrated that KCNQ1OT1/miR‐204 facilitated MSSCC progression by regulating Eph receptor A7 (EphA7). Taken together, these results revealed a novel regulatory mechanism KCNQ1OT1/miR‐204/EphA7 axis, which could provide a new understanding of MSSCC tumorigenesis and develop potential targets for MSSCC therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR‐204/EphA7 axis

Sun

et al. 2019

J of Cellular Biochemistry

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“…LncRNAs may be involved in targeting miRNAs in glioma [29]. Previous research suggests that KCNQ1OT1 can promote cancer progression by acting as a sponge or ceRNA of miRNAs, such as miR-27b-3p and miR-140-5p [13,14]. To find out whether KCNQ1OT1 serves as a ceRNA in migration and invasion, as well as promotion of glioma cell apoptosis.…”

Section: Overexpression Of Kcnq1ot1 Up-regulates Rrm2 Expression By Dmentioning

confidence: 99%

“…Further it has been reported that lncRNA deleted in lymphocytic leukemia 1 (DLEU1) is involved in glioma development [10]. More recently, lncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/antisense transcript 1 (KCNQ1OT1) has been identified as an oncogenic lncRNA that plays a role in promoting progression of cancers, including hepatocellular carcinoma, breast cancer, cholangiocarcinoma and non-small-cell lung carcinoma [11][12][13][14]. Additional studies have shown that knockdown of KCNQ1OT1 repressed proliferation, migration and invasion of glioma by activating the miR-370/CCNE2 axis [15].…”

Section: Introductionmentioning

confidence: 99%

Knockdown of lncRNA KCNQ1OT1 inhibits glioma progression by regulating miR-338-3p/RRM2

et al. 2020

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AbstractThe dysregulated lncRNA play essential roles in glioma development. This study aimed to investigate the role and mechanism of lncRNA potassium voltage-gated channel subfamily Q member 1 opposite strand/ antisense transcript 1 (KCNQ1OT1) in glioma progression. Tumor tissues and adjacent normal samples were collected from 30 glioma patients. The expression levels of lncRNA KCNQ1OT1, microRNA (miR)-338-3p and ribonucleotide reductase M2 (RRM2) were detected by quantitative real-time polymerase chain reaction or western blot analyses. Levels of cell viability, apoptosis, cell migration and invasion in glioma cell lines were determined using cell counting kit-8, flow cytometry with annexin V-FITC and trans-well assays, respectively. The role of KCNQ1OT1 in glioma development in vivo was investigated using a xenograft model. The target association between miR-338-3p and KCNQ1OT1 or RRM2 was validated by luciferase reporter assay. The results found that expression of KCNQ1OT1 was enhanced in glioma tissues and cells, and KCNQ1OT1 knockdown inhibited cell viability, migration and invasion, and xenograft tumor growth, but promoted apoptosis. miR-338-3p was targeted via KCNQ1OT1 and could reverse the effect of KCNQ1OT1 on glioma progression. RRM2 was targeted via miR-338-3p and attenuated the suppressive effect of miR-338-3p on glioma cell viability, migration and invasion. Besides, KCNQ1OT1 overexpression increased RRM2 expression, and this event was weakened via miR-338-3p up-regulation. In conclusion, the present finding suggest that silencing of KCNQ1OT1 can suppress the development and progression of glioma by up-regulating miR-338-3p and down-regulating RRM2.

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“…Recently, increasing evidence suggested that KCNQ1OT1 played an important role in tumorigenesis and metastasis of different cancers . Dong et al revealed KCNQ1OT1 promoted NSCLC progression partly via sponging miR‐27b‐3p in order to target 3′‐untranslated region (3′‐UTR) of HSP90AA1 directly …”

Section: Main Molecular Mechanism Of Lncrna To Regulate the Metastasimentioning

confidence: 99%

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

Fang

Wang

Gong

et al. 2020

J Cellular Molecular Medi

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Non–small‐cell lung cancer (NSCLC) has become the most lethal human cancer because of the high rate of metastasis. Hence, clarifying the molecular mechanism underlying NSCLC metastasis is very important to improve the prognosis of patients with NSCLC. Long non‐coding RNAs (LncRNAs) are a class of RNA molecules longer than 200 nucleotides, which can participate in diverse biological processes. About 18% of human LncRNAs were recently found to be associated with tumours. Many studies indicated that aberrant expression of LncRNAs played key roles in the progression and metastasis of NSCLC. According to the function in tumours, LncRNAs can be divided into two classes: oncogenic LncRNAs and tumour‐suppressor LncRNAs. In this review, we summarized the main molecular mechanism of LncRNAs regulating NSCLC metastasis, including three aspects: (a) LncRNAs interact with miRNAs as ceRNAs; (b) LncRNAs bind with target proteins; and (c) LncRNAs participate in the transduction of different signal pathways. Then, LncRNAs can exert their function to regulate the metastasis of NSCLC through influencing the progression of epithelial‐mesenchymal transition (EMT) and the properties of cancer stem cell (CSC). But, it is necessary to do some further research to demonstrate the LncRNAs particular regulatory mechanism of inhibiting the metastasis of NSCLC and explore new drugs targeting LncRNAs.

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KCNQ1OT1 facilitates progression of non‐small‐cell lung carcinoma via modulating miRNA‐27b‐3p/HSP90AA1 axis

Cited by 67 publications

References 43 publications

Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR‐204/EphA7 axis

Long noncoding RNA KCNQ1OT1 promotes proliferation, migration, and invasion in maxillary sinus squamous cell carcinoma by regulating miR‐204/EphA7 axis

Knockdown of lncRNA KCNQ1OT1 inhibits glioma progression by regulating miR-338-3p/RRM2

Long non‐coding RNAs: How to regulate the metastasis of non–small‐cell lung cancer

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