KCNJ11 polymorphism is associated with type 2 diabetes mellitus in Iraqi patients

Muftin, Najlaa Qassim; Jubair, Suzanne

doi:10.1016/j.genrep.2019.100480

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…Clearly, there seems to be an inter-ethnic variation operative amongst these populations. The E23K was found associated with T2DM in Iraqi patients(Muftin and Jubair 2019)…”

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confidence: 89%

Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy

Rizvi

Raza

Rashid³

et al. 2023

Preprint

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Purpose: Diabetic nephropathy (DN) affects almost 40% of diabetic patients and is clinically categorized by declining glomerular filtration rate, proteinuria and hypertension, ultimately leads to renal failure. Genome-wide association studies (GWAS) have identified several genetic loci associated with DN, including various genetic variants. This study was thus conducted to find an association of NPHS2, PON1 and KCNJ11 gene variants with the risk of DN. Method: This case-control study was performed in 300 unrelated subjects consisting of 150 DN patients and 150 controls that were age, sex and ethnicity matched. Genotyping was done using PCR-RFLP and primers amplification refractory mutation system-PCR approach. Results were analyzed using SPSSS ver.21 software. Result: In context to KCNJ11, OR values for KK and EE genotypes were 4.163(P<0.001) and 0.397(P=0.001), respectively. Frequencies of K and E alleles were 57.33% and 42.67% in DN cases as compared to 39% and 61% in controls (OR=2.101, 0.476). The OR values for K and E alleles were 2.101(P<0.001) and 0.476(P<0.001), respectively. In PON1, the OR values for AA and GG genotypes were 0.66(P=0.08) and 5.86(P=0.011) respectively. The OR values for A and G alleles were 0.64 (P=0.021)and 1.569 (P=0.021)respectively. No significant association of NPHS2 gene was observed on comparing genotype and allele frequencies among cases and controls. Conclusion: KCNJ11and PON1 genes could serve as genetic biomarkers for establishing DN susceptibility. Early identification of genetic risk factors in patients enables earlier intervention, eventually delaying and dropping the effect of DN.

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“…Clearly, there seems to be an inter-ethnic variation operative amongst these populations. The E23K was found associated with T2DM in Iraqi patients(Muftin and Jubair 2019)…”

mentioning

confidence: 89%

Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy

Rizvi

Raza

Rashid³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

Genetic screening for pathogenic variants in type 2 diabetes of the Arab Gulf population: A systematic review and meta-analysis

Musafer,

Rava,

Al-Shuhaib

2023

Int J Diabetes Dev Ctries

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Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case–control study and meta-analysis

Moazzam-Jazi

Bonab

Akbarzadeh

et al. 2022

Sci Rep

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Due to the central role in insulin secretion, the potassium inwardly-rectifying channel subfamily J member 11 (KCNJ11) gene is one of the essential genes for type 2 diabetes (T2D) predisposition. However, the relevance of this gene to T2D development is not consistent among diverse populations. In the current study, we aim to capture the possible association of common KCNJ11 variants across Iranian adults, followed by a meta-analysis. We found that the tested variants of KCNJ11 have not contributed to T2D incidence in Iranian adults, consistent with similar insulin secretion levels among individuals with different genotypes. The integration of our results with 72 eligible published case–control studies (41,372 cases and 47,570 controls) as a meta-analysis demonstrated rs5219 and rs5215 are significantly associated with the increased T2D susceptibility under different genetic models. Nevertheless, the stratified analysis according to ethnicity showed rs5219 is involved in the T2D risk among disparate populations, including American, East Asian, European, and Greater Middle Eastern, but not South Asian. Additionally, the meta-regression analysis demonstrated that the sample size of both case and control groups was significantly associated with the magnitude of pooled genetic effect size. The present study can expand our knowledge about the KCNJ11 common variant's contributions to T2D incidence, which is valuable for designing SNP-based panels for potential clinical applications in precision medicine. It also highlights the importance of similar sample sizes for avoiding high heterogeneity and conducting a more precise meta-analysis.

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KCNJ11 polymorphism is associated with type 2 diabetes mellitus in Iraqi patients

Cited by 4 publications

References 18 publications

Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy

Association of NPHS2, PON1 and KCNJ11 Gene Polymorphisms with Diabetic Nephropathy

Genetic screening for pathogenic variants in type 2 diabetes of the Arab Gulf population: A systematic review and meta-analysis

Risk of type 2 diabetes and KCNJ11 gene polymorphisms: a nested case–control study and meta-analysis

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