MYH3-associated non-syndromic palatoschisis (cleft palate, CP) in Limousine cattle
BACKGROUNDPalatoschisis (also called cleft palate) is an opening or cleft in the upper lip, the roof of the palate, or both, and is a common defect in both humans and domestic animals (Mossey & Modell, 2012;Mulvihill et al., 1980). It can also occur in cattle as an isolated (non-syndromic) birth defect (OMIA 000197-9913), or it is associated with familial or sporadic genetic syndromes, such as the recessively inherited CHRNB1-related arthrogryposis multiplex congenita in Red dairy cattle (Agerholm et al., 2016; OMIA 000070-9913), or the reported isolated case of KCNG1-related neuromuscular channelopathy (Jacinto et al., 2021; OMIA 002483-9913).