Kayser-Fleischer-Like Rings in Patients Without Wilson's Disease

Frommer, D.; Morris, John; Sherlock, Sheila; Abrams, J.D.; Newman, Steven P.

doi:10.1016/s0016-5085(77)80038-3

Cited by 70 publications

(14 citation statements)

References 17 publications

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“…A slit‐lamp examination by an experienced observer is required to identify Kayser‐Fleischer rings in most patients. They are not entirely specific for WD, because they may be found in patients with chronic cholestatic diseases49–51 and in children with neonatal cholestasis52; however, these disorders can usually be distinguished from WD on clinical grounds. Large series of patients with WD show that Kayser‐Fleischer rings are present in only 44%‐62% of patients with mainly hepatic disease at the time of diagnosis 19, 53–56.…”

Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and treatment of Wilson disease: An update

Roberts¹,

2008

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Section: Clinical Featuresmentioning

confidence: 99%

Diagnosis and treatment of Wilson disease: An update

Roberts¹,

2008

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“…A slit-lamp examination by an experienced observer is required to identify Kayser-Fleischer rings in most patients. They are not entirely specific for WD, since they may be found in patients with chronic cholestatic diseases [39][40][41] and in children with neonatal cholestasis. 42 Large series of patients with WD show that Kayser-Fleischer rings are present in only 50% to 62% of patients with mainly hepatic disease at the time of diagnosis.…”

Section: Kayser-fleischer Ringmentioning

confidence: 99%

A practice guideline on Wilson disease

2003

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PreambleThis guideline is intended for use by physicians. It describes preferable up-to-date approaches to the diagnosis and treatment of patients with Wilson disease. As their purpose is to direct patient care, these guidelines should not be considered inflexible mandates. They have been developed in a manner consistent with the American Association for the Study of Liver Diseases Policy Statement on Development and Use of Practice Guidelines.These guidelines provide data-supported approaches to the diagnosis and management of patients with Wilson disease. They are based on, first, broad-based review of the published literature in pediatrics and medicine including Medline searches on hepatolenticular degeneration and related subjects; and second, 40 accumulated years of personal experience of the authors. In order to standardize recommendations as much as possible, each has been characterized with Roman numerals I through IV to indicate the quality of evidence on which the recommendation is based (Table 1). 1 A significant problem with the literature on Wilson disease is that patients are sufficiently rare to preclude large cohort studies or randomized controlled trials; moreover, most treatment modalities were developed at a time when conventions for drug assessment were less stringent than currently.

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“…Fifthly, a slit-lamp examination by an experienced observer is required to identify Kayser-Fleischer rings in most patients. ey are not entirely speci c for WD, because they may be found in patients with chronic cholestatic diseases [8][9][10] . In our case bilateral KF ring are present due to WD as chronic cholestasis excluded.…”

Section: Discussionmentioning

confidence: 99%