Kawasaki syndrome and concurrent Coxsackie virus B3 infection

Rigante, Donato; Cantarini, Luca; Piastra, Marco; Angelone, Donatella Francesca; Valentini, Piero; Pardeo, Manuela; Buonsenso, Danilo; Delogu, Angelica Bibiana; Serranti, Daniele; Nisco, Alessia De; Compagnone, Adele; Rosa, Gabriella De

doi:10.1007/s00296-010-1613-0

Cited by 13 publications

(14 citation statements)

References 26 publications

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“…Several studies have shown that human bocavirus may play a pathogenic role in the development of KD using direct specimen tests from KD patients 10)15). The association with enterovirus such as coxsackie virus and KD occurrence also has been suggested from several case series 11)16)…”

Section: Discussionmentioning

confidence: 98%

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Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

et al. 2014

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Background and ObjectivesThis study is aimed at elucidating potential temporal associations between the occurrence of Kawasaki disease (KD) and various viral infections.Subjects and MethodsWe obtained monthly patterns of KD from the seventh nationwide survey and viral detection data from the Korea Centers for Disease Control and Prevention from 2009 to 2011 and evaluated temporal correlations between them for each month. The respiratory viruses detected using a multiplex real-time-polymerase chain reaction kit were influenza virus (A/H1N1, A/H3N2, A/H5N1, and B), adenovirus, parainfluenza virus (type 1, 2, 3), respiratory syncytial virus (type A, B), human rhinovirus, human coronavirus (OC43/229E, NL63), human bocavirus, and enterovirus.ResultsWe obtained data from a total of 13031 patients who were treated for acute KD from 87 hospitals with pediatric residence programs. During this survey, KD showed highest overall incidence in summer and winter seasons and lowest incidence in February and October. We received viral detection data for a total of 14267 patients. Viral detection was highest during winter and spring seasons. The most commonly detected virus was human rhinovirus (32.6%), followed by influenza virus (26.8%). The monthly incidence of KD showed significant correlation with the monthly overall viral detection (p=0.022, r=0.382). In particular, human bocavirus and enterovirus have significant correlations with monthly patterns of KD occurrence (p=0.032 and p=0.007, respectively) and influenza virus correlated with KD occurrence with borderline significance (p=0.063).ConclusionThe temporal association between monthly occurrence of KD and viral detection suggests the etiologic importance of precedent infection in the development of KD.

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Section: Discussionmentioning

confidence: 98%

“…Both of these epidemiologic features suggested that some kind of infection is one of the causes of KD 7). While several researchers have reported diverse organisms as the causative agents of KD,8)9)10)11) a definitive cause has not been identified.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

et al. 2014

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“…These are commonly found pathogens. 13 However, the reason why only some patients infected with these viruses develop KD is unknown. A report demonstrated coinfection with Coxsackievirus B3 in a patient with KD.…”

Section: Discussionmentioning

confidence: 99%

Adult-onset Kawasaki disease (mucocutaneous lymph node syndrome) and concurrent Coxsackievirus A4 infection: a case report

Ueda¹,

Kenzaka²,

Noda³

et al. 2015

IMCRJ

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IntroductionKawasaki disease (KD) most commonly develops in infants, although its specific cause is still unclear. We report here a rare case of adult-onset KD which revealed to be concurrently infected by Coxsackievirus A4.Case presentationThe patient was a 37-year-old Japanese man who presented with fever, exanthema, changes in the peripheral extremities, bilateral non-exudative conjunctival injection, and changes in the oropharynx, signs that meet the diagnostic criteria for KD defined by the Centers for Disease Control and Prevention. In this case, the patient had a significantly high antibody titer for Coxsackievirus A4, which led us to presume that the occurrence of KD was concurrent Coxsackievirus A4 infection.ConclusionWe reported a very rare case of KD which suggests that the disease can be concurrent Coxsackievirus A4 infection. Although KD is an acute childhood disease, with fever as one of the principal features, KD should also be considered in the differential diagnosis when adult patients present with a fever of unknown cause associated with a rash.

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“…Even though the aetiology of Kawasaki disease and other paediatric inflammatory conditions is not yet understood, there is general agreement that stimulating the immune system triggers uncontrolled responses that generate inflammatory diseases. We know that viruses are the most frequently described triggers in Kawasaki disease 5,6 . Cases of Kawasaki disease have been described every year for decades, thousands have life‐long health consequences and a minority die.…”

Section: Introductionmentioning

confidence: 99%

Kawasaki syndrome and concurrent Coxsackie virus B3 infection

Cited by 13 publications

References 26 publications

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

Evaluation of the Temporal Association between Kawasaki Disease and Viral Infections in South Korea

Adult-onset Kawasaki disease (mucocutaneous lymph node syndrome) and concurrent Coxsackievirus A4 infection: a case report

Disease and age‐related inequalities in paediatric research, funding and communication: Lessons from the COVID‐19 pandemic

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