Kawasaki disease shock syndrome in the COVID-19 pandemic

Gámez-González, Luisa Berenise; Ramírez-López, Moisés; Colmenero-Rascón, Marcela; Yamazaki‐Nakashimada, Marco Antonio

doi:10.1017/s1047951121003280

Cited by 5 publications

(10 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study shows a large overlap between the clinical signs and laboratory data of PIMS‐TS, KD, and KSS. The clinical similarities between PIMS‐TS, KD, and KSS, their similar response to immunomodulatory treatment, and previous hypothesis about viral triggers for KD, give support to the theory that PIMS‐TS is part of a spectrum of KD‐related conditions or a specific form of KD triggered by SARS‐CoV‐2, 19,20 however, evidence in this regard is incomplete 21–25 . In typical KD, 80% of the patients are less than 5 years old, whereas our patients had a median age of 6 years, as has been observed in incomplete and atypical KD, and in KSS 13,14,19 .…”

Section: Discussionsupporting

confidence: 86%

“…The clinical similarities between PIMS-TS, KD, and KSS, their similar response to immunomodulatory treatment, and previous hypothesis about viral triggers for KD, give support to the theory that PIMS-TS is part of a spectrum of KD-related conditions or a specific form of KD triggered by SARS-CoV-2, 19,20 however, evidence in this regard is incomplete. [21][22][23][24][25] In typical KD, 80% of the patients are less than 5 years old, whereas our patients had a median age of 6 years, as has been observed in incomplete and atypical KD, and in KSS. 13,14,19 This is consistent with previous studies which reported an even higher median age than ours (between 8 and 10 years) for PIMS-TS patients.…”

Section: Discussionsupporting

confidence: 60%

See 1 more Smart Citation

Multicentre observational study on multisystem inflammatory syndrome related to COVID‐19 in Argentina

Vainstein

Baleani

Urrutia

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

BACKGROUND The impact of the Pediatric Inflammatory Multisystem Syndrome temporally‐associated with SARS‐CoV‐2 (PIMS‐TS) in low and middle‐income countries remains poorly understood. Our aim was to understand the characteristics and outcomes of PIMS‐TS in Argentina. METHODS This observational, prospective and retrospective multicenter study, enrolled patients younger than 18 years‐old showing PIMS‐TS, Kawasaki disease (KD) or Kawasaki shock syndrome (KSS) manifestations between March 2020 and May 2021. Patients were followed‐up until hospital discharge or death (which occurred in one case). The primary outcome was PICU admission. Multiple logistic regression was used to identify variables predicting PICU admission. RESULTS Eighty‐one percent, 82% and 14% of the 176 enrolled patients fulfilled the suspect case criteria for PIMS‐TS, KD, and KSS, respectively. Temporal association with SARS‐CoV‐2 was confirmed in 85% of the patients and 38% were admitted to PICU. The more common clinical manifestations were fever, abdominal pain, rash and conjunctival injection. Lymphopenia was more common among PICU‐admitted patients (87% versus 51%, p<0.0001), who also showed a lower platelet count and higher plasmatic levels of inflammatory and cardiac markers. Mitral valve insufficiency, left ventricular wall motion alterations, pericardial effusion and coronary arteries alterations were observed in 30%, 30%, 19.8%, 18.6% of the patients, respectively. Days to initiation of treatment, rash, lymphopenia, and low platelet count did significant independent contributions to PICU admission. CONCLUSION Rates of severe outcomes of PIMS‐TS in the present study agreed with those observed in high‐income countries. Together with other published studies, this work helps to better understand this novel clinical entity.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 60%

Multicentre observational study on multisystem inflammatory syndrome related to COVID‐19 in Argentina

Vainstein

Baleani

Urrutia

et al. 2023

Pediatrics International

View full text Add to dashboard Cite

show abstract

“…As with MIS-C, KDSS often presents with gastrointestinal symptoms with severe inflammation, and it can be mistaken as acute abdomen, TSS, septic shock, or MODS [ 11 , 12 ]. KDSS and MIS-C may present a variety of clinical manifestations, and delayed recognition of the disease can result in a fatal outcome [ 14 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…Table 5 compares the important characteristics of MIS-C, KDSS, and KD, utilizing data from a United States study on MIS-C ( n = 186) [ 26 ], a literature review on KDSS ( n = 103) [ 13 ], and a Korean nationwide survey on KD ( n = 14,916) [ 28 ]. Unlike KD, both MIS-C and KDSS predominantly affect patients older than five years [ 18 ]. Whereas KD is frequent in East Asia (Japan, Korea, and Taiwan), both MIS-C and KDSS are relatively frequent in Europe and North America (Hispanic and black populations) and rare in East Asia (Asian populations) [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…The term was coined in 2009 by Kanegaye et al [ 15 ] to differentiate this severe form from hemodynamically stable KD. In fact, KDSS is distinct in various aspects [ 16 , 17 , 18 ]. Coronary artery abnormalities (CAAs) and intravenous immunoglobulin (IVIG) resistance, a major concern in the field of KD research, are more common in KDSS than in hemodynamically stable KD [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Lee,

Kim,

Cho

et al. 2023

Children

View full text Add to dashboard Cite

This study aimed to investigate the characteristics of COVID-19-associated multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease shock syndrome (KDSS) and to compare the similarities and differences between the two diseases. The incidence of KDSS and MIS-C was also estimated. Medical records of patients diagnosed with MIS-C or KDSS at four hospitals from January 2013 to December 2022 were retrospectively reviewed. Thirty-one patients were enrolled in the study in either an MIS-C group (n = 22) or a KDSS group (n = 9). The incidence of KDSS in KD was 0.8% (9/1095) and the incidence of MIS-C versus KD was 10.2% (22/216). Compared with the MIS-C group, the KDSS group had longer hospital stays and more severe systemic inflammation (e.g., anemia, elevated C-reactive protein, hypoalbuminemia, and pyuria) and organ dysfunction (e.g., number of involved organs, shock, vasoactive infusion, and intensive care unit admission). All patients in the MIS-C group, but none in the KDSS group, including two patients during the COVID-19 pandemic, had laboratory evidence of SARS-CoV-2 infection. MIS-C and KDSS shared demographic, clinical, and laboratory characteristics; organ dysfunction; treatment; and outcomes. Overall severity was more severe in patients with KDSS than in those with MIS-C. The most important difference between MIS-C and KDSS was whether SARS-CoV-2 was identified as an infectious trigger.

show abstract

Progress in the Diagnosis and Treatment of Kawasaki Disease Shock Syndrome

陈

2023

ACM

View full text Add to dashboard Cite

Kawasaki disease shock syndrome in the COVID-19 pandemic

Cited by 5 publications

References 9 publications

Multicentre observational study on multisystem inflammatory syndrome related to COVID‐19 in Argentina

Multicentre observational study on multisystem inflammatory syndrome related to COVID‐19 in Argentina

Similarities and Differences between Multisystem Inflammatory Syndrome in Children (MIS-C) and Kawasaki Disease Shock Syndrome

Progress in the Diagnosis and Treatment of Kawasaki Disease Shock Syndrome

Contact Info

Product

Resources

About