Kawasaki Disease in Korea, 2003–2005

Park, Yong-Won; Han, Ji-Whan; Park, In-Sook; Kim, Chang Hwi; Cha, Sung-Ho; Ma, Jae-Sook; Lee, Joon Sung; Kwon, Tae Chan; Lee, Sang-Bum; Kim, Chul‐Ho; Lee, Heung-Jae; Yun, Young Soo

doi:10.1097/inf.0b013e318124aa1a

Cited by 62 publications

(41 citation statements)

References 8 publications

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“…It has been reported that boys have 1.5 times higher incidence than girls in Korea (Park et al 2007(Park et al , 2010. In consideration of the higher incidence of KD in males, we analyzed the data separately by sex.…”

Section: Discussionmentioning

confidence: 99%

“…There are several lines of evidence to support a genetic contribution to disease susceptibility and outcome. The incidence of KD is 12-19 times higher in Japanese and Koreans than in Caucasians Park et al 2007;Holman et al 2003), and it is maintained in JapaneseAmerican residents in the United States (Holman et al 2005). The risk of KD occurrence in twins and siblings of an index case is higher than that in the normal population (Fujita et al 1989;Harada et al 1986); and the incidence of KD in children whose parents have a history of KD is twice as high as that in the general population (Fujita et al 1989;Uehara et al 2003).…”

Section: Introductionmentioning

confidence: 96%

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A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

et al. 2011

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Kawasaki disease (KD) is an acute self-limited vasculitis of infants and children that manifests as fever and signs of mucocutaneous inflammation. Coronary artery aneurysms develop in approximately 15-25% of untreated children. Although the etiology of KD is largely unknown, epidemiologic data suggest the importance of genetic factors in the susceptibility to KD. In order to identify genetic variants that influence KD susceptibility, we performed a genome-wide association study (GWAS) using Affymetrix SNP array 6.0 in 186 Korean KD patients and 600 healthy controls; 18 and 26 genomic regions with one or more sequence variants were associated with KD and KD with coronary artery lesions (CALs), respectively (p < 1 × 10(-5)). Of these, one locus on chromosome 1p31 (rs527409) was replicated in 266 children with KD and 600 normal controls (odds ratio [OR] = 2.90, 95% confidence interval [CI] = 1.85-4.54, P (combined) = 1.46 × 10(-6)); and a PELI1 locus on chromosome 2p13.3 (rs7604693) was replicated in 86 KD patients with CALs and 600 controls (OR = 2.70, 95% CI = 1.77-4.12, P (combined) = 2.00 × 10(-6)). These results implicate a locus in the 1p31 region and the PELI1 gene locus in the 2p13.3 region as susceptibility loci for KD and CALs, respectively.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

et al. 2011

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“…The incidence of Kawasaki disease was observed to be highest in Asians, intermediate in non-Hispanic African-Americans and Hispanics, and lowest in Caucasians (32.5, 16.9, 11.1, and 9.1 per 100,000 children less than 5 years old, respectively) [3]. The incidence rate in Korea was 105 per 100,000 children less than 5 year old [4]. Treatment with intravenous immunoglobulin (IVIG) abrogates the inflammation in approximately 80% of affected individuals and reduces the aneurysm rate to less than 5% [5].…”

Section: Introductionmentioning

confidence: 95%

Genetic variants in the HLA-G region are associated with Kawasaki disease

Kim

Hong

et al. 2008

Human Immunology

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“…The highest incidence rate of Kawasaki disease is seen in Japan and in a four-year epidemiological survey between 1999 and 2002, the average incidence rate was 137.7 cases per 100000 children under 5 years of age. In an epidemiological survey in Korea, the incidence rate between 2003 and 2005 was approximately 105 cases per 100000 children under 5 years of age, a rate that was the second highest in the world after Japan (270). …”

Section: Prefacementioning

confidence: 99%

Korean Guidelines for the Appropriate Use of Cardiac CT

et al. 2015

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The development of cardiac CT has provided a non-invasive alternative to echocardiography, exercise electrocardiogram, and invasive angiography and cardiac CT continues to develop at an exponential speed even now. The appropriate use of cardiac CT may lead to improvements in the medical performances of physicians and can reduce medical costs which eventually contribute to better public health. However, until now, there has been no guideline regarding the appropriate use of cardiac CT in Korea. We intend to provide guidelines for the appropriate use of cardiac CT in heart diseases based on scientific data. The purpose of this guideline is to assist clinicians and other health professionals in the use of cardiac CT for diagnosis and treatment of heart diseases, especially in patients at high risk or suspected of heart disease.

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Kawasaki Disease in Korea, 2003–2005

Abstract: The average annual rate of incidence, 105.0/100,000 in children <5-year-old is the second highest reported rate in the world.

Cited by 62 publications

References 8 publications

A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease

Genetic variants in the HLA-G region are associated with Kawasaki disease

Korean Guidelines for the Appropriate Use of Cardiac CT

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