Kawasaki Disease in a Father and Son

Iwata, Fujihiko; Hanawa, Yoshio; Takashima, H; Shimoura, Keichou; Nishibayashi, Youhei

doi:10.1111/j.1442-200x.1992.tb00930.x

Cited by 13 publications

(10 citation statements)

References 3 publications

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“…Previous epidemiologic studies support the hypothesis of an increased susceptibility to KD in individuals of east Asian ethnicity and their siblings [11][12]. Some studies have linked a predisposition to KD to HLA, whereas other studies dispute such a link [8,10,13]. A recent study of differing Japanese populations supports the hypothesis that some unidentified infectious agents trigger the genetically-influenced immune response via immunoglobulin allotypic markers that are inherited as codominant autosomal alleles, which cause a susceptibility to KD [13].…”

Section: Discussionmentioning

confidence: 88%

Tendency toward atopy in Kawasaki disease

Matsuoka¹,

Tatara²,

Nakagawa³

et al. 1996

Eur J Pediatr

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Section: Discussionmentioning

confidence: 88%

Tendency toward atopy in Kawasaki disease

Matsuoka¹,

Tatara²,

Nakagawa³

et al. 1996

Eur J Pediatr

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“…To the best of our knowledge, this is the third description of a child whose father or mother also suffered from KD (2,3). It has been postulated that there is a genetically determined component to KD, based on the following observations.…”

mentioning

confidence: 87%

“…An echocardiogram found no coronary dilatation when the patient was discharged 4 wk after admission. The HLA antigens were examined and the results are shown in Table 1, together with cases reported previously in the literature (2,3).…”

mentioning

confidence: 99%

Kawasaki disease in a father and daughter

Kaneko¹

1999

Acta Paediatrica

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tensivists in Malaysia, Europe and North America recognize futile treatment and apply care restrictions widely. We have shown previously that these decisions were influenced by family ethnicity, religious beliefs and paediatrician bias (3). This current study concurs with Martinot's findings that severity of illness, such as the PRISM score and the extent of multiple organ dysfunction, was poorly predictive of the modes of death. Despite recognizing that quality of life assessments were important in end-of-life decisions, it appears that pre-existing handicap was not associated with the use of care limitation. Factors that influence end-of-life decision-making are increasingly recognized. However, severity of illness and pre-existing functional status could not be used to predict the different end-of-life events in critically ill children. We agree with the authors that the next step is to study the ethical processes leading to care restrictions and investigate international differences in the application of such orders. References

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“…Eighty percent of cases occur in children less than 5 years of age and the incidence peaks at about 11–12 months. However, KD may occur at any age, with cases reported in neonates 18 and adults 19 . Children from all ethnic backgrounds, including Indigenous Australians, may develop KD but the incidence is higher in children of East Asian descent, even when they reside outside Asia 20 .…”

Section: Epidemiology Aetiology and Sequelae Of Kawasaki Diseasementioning

confidence: 99%

The diagnosis and management of Kawasaki disease

Royle

Burgner

Curtis

2005

J Paediatrics Child Health

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Kawasaki disease (KD) is a systemic vasculitis of childhood with a predilection for the coronary arteries. It is the predominant cause of paediatric acquired heart disease in developed countries. The aetiology of KD remains unknown and consequently there is no diagnostic test. The diagnosis is made using a constellation of clinical criteria that in isolation have poor sensitivity and specificity. Early treatment prevents overt coronary artery damage in the majority of children. The long-term effects of childhood KD on later cardiovascular health remain unknown. A recent study showed that treatment of KD in Australia is suboptimal, with late diagnosis occurring in approximately half of the cases and an unacceptably high incidence of acute cardiac involvement. These guidelines highlight the difficulties in the diagnosis of KD and offer some clues that may assist early recognition of this important paediatric disease. They also detail current treatment recommendations and the evidence on which they are based. Increased awareness of the epidemiology and spectrum of the clinical presentation of KD is essential for early recognition and optimal management.

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Kawasaki Disease in a Father and Son

Cited by 13 publications

References 3 publications

Tendency toward atopy in Kawasaki disease

Tendency toward atopy in Kawasaki disease

Kawasaki disease in a father and daughter

The diagnosis and management of Kawasaki disease

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