Kawasaki disease: a clinical and epidemiological study of 70 children in Brazil

Magalhães, Cristina Medeiros Ribeiro de; Vasconcelos, Patricia A C; Pereira, Marne R; Alves, Natália R. Magalhães; Gandolfi, Lenora; Pratesi, Riccardo

doi:10.1258/td.2008.080124

Cited by 8 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Brazil, a delayed diagnosis of KD by the primary physician is frequent even in age groups where KD is more prevalent. As found in a previous study from our laboratory, the most frequent misdiagnoses of KD were allergic reactions and exanthematous infectious diseases of infancy [11].…”

Section: Introductionsupporting

confidence: 78%

“…Coronary aneurysms appear in 15% to 25% of cases [7], often silent, and may be recognized only years later in the event of sudden death or myocardial infarction [4,7]. There are many infectious diseases more prevalent than KD that present as acute febrile illnesses of childhood, confounding the diagnosis of KD [11,16].…”

Section: Discussionmentioning

confidence: 99%

“…Today, REKAMLATINA is the largest multinational network studying the epidemiology of KD in children [12]. Nevertheless, as previously noted, epidemiological studies focusing on KD are still rare both in Brazil and throughout Latin America [3,[11][12][13].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Magalhães¹,

Almeida²,

Gandolfi³

et al. 2020

Medicina

Self Cite

View full text Add to dashboard Cite

Background and objectives: The present study is the first known in Latin America to enroll a substantial number of Kawasaki disease (KD) patients with an extended follow-up. This study aimed to: (1) to expose the difficulties and delays in the diagnosis of KD in a developing country, (2) to describe and correlate the clinical features of this disorder with the children’s age at the time of disease onset, (3) to correlate the frequent lack of early diagnosis with a delayed application of appropriate treatment, and (4) to describe the outcome and eventual recurrences of KD in our region. Materials and Methods: Three hundred and one participants (183 males and 118 females) included in the study were diagnosed and, subsequently, clinically followed for ten years (January 2007 to December 2016) at the Pediatric Rheumatology Walk-in Clinic of the Children’s Hospital of Brasilia. Results: Episodes ranged from four months to two years. This rate of recurrence was well-above that disclosed by previous reports. Delay in diagnosis, in all age groups, caused an undesirable delay between the disease onset, the final diagnosis, and the administration of intravenous immunoglobulin (IVIG). KD recurred in 25 (8.3%) of the children during the first three years of follow-up. In seven patients, KD recurred twice, with an interval between episodes ranging from four months to two years. Conclusions: This rate of recurrence was well-above that disclosed by previous reports. In Latin America, aside from a handful of physicians and researchers, KD is being ignored. There is a pressing need to educate primary health care physicians and bring awareness to the fact that KD is not an exotic condition that affects only the Asian populations but a disorder that already exists among us and that frequently results in severe consequences.

show abstract

Section: Introductionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Magalhães¹,

Almeida²,

Gandolfi³

et al. 2020

Medicina

Self Cite

View full text Add to dashboard Cite

show abstract

“…This often results in a wrong, delayed, or missed diagnosis. Studies from other resource-limited countries, such as Brazil, showed that only 46% of children with KD were referred and treated promptly within the rst ten days of onset of symptoms, and only 21% of them were referred with the correct diagnosis [10] . Among that cohort CAAs developed in 18.5%.…”

Section: Discussionmentioning

confidence: 99%

Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Alzyoud¹,

El-Kholy²,

Arab

et al. 2023

Pediatr Cardiol

View full text Add to dashboard Cite

Kawasaki Disease (KD) is still the most common acquired heart disease in children below the age of ve years; it has been well described in the developed world; however, data from the Arab world are limited to case reports or single-center case series. In an effort of optimizing KD research in the Arab world, a group of physicians and researchers established the KD Arab Initiative (Kawarabi) in 2021, and published the rst survey, which showed disparities in the availability of intravenous immunoglobulin (IVIG); this had prompted Kawarabi to assess the access to care and therapy of KD patients in Arab countries. A 32 structured questions survey was conducted in thirteen Arab countries and addressed KD patients' access to healthcare in urban and rural settings. The survey results showed that access to care was uniform across large, mid-size cities and rural areas in 7/13 (54%) countries, while in 6/13 (46%) countries, it was in favor of large and mid-size cities over rural areas. The quality of medical services received by children with KD in large cities was rated as excellent in 6/13 or good in 7/13 countries compared to fair in 4/13 or poor in 4/13 countries in rural areas. Availability of IVIG was limited (23%) in mid-size cities and almost impossible (23%) in rural areas. The KD patients in mid-size cities and rural areas have limited access to standard healthcare in the Arab world. This survey laid the foundation for future Kawarabi endeavors to improve the care of children with KD.

show abstract

“…Most studies of KD in Chile and Latin America report single-center experiences [12][13][14][15]. However, to our knowledge, population-based epidemiological studies of KD in Latin American countries have not been conducted.…”

Section: Introductionmentioning

confidence: 99%

Rising hospitalization rates of Kawasaki Disease in Chile between 2001 and 2007

et al. 2011

View full text Add to dashboard Cite

Incidence of Kawasaki disease (KD) varies geographically, with highest rates in East Asia and comparatively lower rates in Europe and United States. Population-based epidemiologic studies of KD in Latin American countries have not been done. The purpose of this study is to determine demographic characteristics, hospitalization rates and estimated incidence of KD in Chile. We performed a retrospective review of national hospital discharge databases between 2001 and 2007 for patients younger than 18 years of age with KD (ICD10 code M30.3). Seven hundred and eighty-six hospitalizations with discharge diagnosis of KD were identified, representing 0.03% of hospitalizations. Median age of diagnosis was 1 year, and 85% of patients were younger than 5 years. Male-to-female ratio was 1.6:1. Highest hospitalization rates occurred in late winter/spring (August-November) with a smaller peak in summer (March). KD-associated hospitalization rate was 7.6 per 100,000 children younger than 5 years (95% CI 7.0-8.1). Hospitalization rates increased 47% between 2001-2004 and 2005-2007 periods: 6.3 (95% CI 5.6-7.0) to 9.3 (95% CI 8.3-10.3), (P < 0.001). Estimated incidence of KD, assuming 10% readmission rates, was 6.8 (95% CI 6.3-7.4), increasing from 5.7 (95% CI 5.0-6.3) in 2001-2004 to 8.4 (95% CI 7.4-9.3) in 2005-2007 (P < 0.001). In conclusion, demographic characteristics of Chilean patients with KD are similar to international data. There has been an increase in hospitalization rates and estimated incidence of KD in Chile between 2001 and 2007. This may reflect a true increase in cases or improved awareness.

show abstract

Kawasaki disease: a clinical and epidemiological study of 70 children in Brazil

Cited by 8 publications

References 12 publications

Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Clinical Manifestations of Kawasaki Disease at Different Age Spectrum: A Ten-Year Study

Access to Care and Therapy for Kawasaki Disease in the Arab Countries: A Kawasaki Disease Arab Initiative (Kawarabi) Multicenter Survey

Rising hospitalization rates of Kawasaki Disease in Chile between 2001 and 2007

Contact Info

Product

Resources

About