Kaurenoic Acid from Pulp of <i>Annona cherimolia</i> in regard to Annonaceae‐induced Parkinsonism

Guillopé, R.; Escobar-Khondiker, Myriam; Guérineau, Vincent; Laprévôte, Olivier; Höglinger, Günter U.; Champy, Pierre

doi:10.1002/ptr.3508

Cited by 13 publications

(9 citation statements)

References 26 publications

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“…2 , 3 , and 5 – 8 did not exhibit significant cytotoxicity in the concentration range of 12.5–100 μM ( Table 1 ), thus the NO inhibiting effects were probably not due to cytotoxicity. Among the tested compounds, 2 , and 5–8 belonged to the ent -kaurane diterpenoids noted for the occurrence in the Annona species [ 16 , 17 ]. In the previous literature, kaurenoic acid ( 2 ) was reported to inhibit NO production, prostaglandin E2 release, cyclooxygenase-2, and inducible nitric oxide synthase expression in LPS-induced RAW264.7 macrophages [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

et al. 2013

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In the present study, the chemical investigation of the leaves of Annona reticulata has resulted in the identification of nine compounds, including annonaretin A, (1), a new triterpenoid. The purified compounds were subjected to the examination of their effects on NO inhibition in LPS-activated mouse peritoneal macrophages and most of them exhibited significant NO inhibition, with IC50 values in the range of 48.6 ± 1.2 and 99.8 ± 0.4 μM.

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Section: Resultsmentioning

confidence: 99%

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

et al. 2013

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“…In addition, to treat gastrointestinal disorders such stomach pain, diarrhea, and dysentery; at present, it is used to treat diabetes. [ 16 19 20 ] Phytochemical investigations revealed the presence of alkaloids, flavonoids, sterols,[ 20 21 22 23 24 ] terpenoids,[ 25 26 27 ] cyclic peptides,[ 28 29 ] and acetogenins. [ 30 31 ] With regard to pharmacological investigations have been reported that A. cherimola extracts possess genotoxic, cytotoxic,[ 31 32 33 ] antihypercholesterolemic,[ 23 ] antihyperlipidemic[ 34 ] antidepressant,[ 22 ] cryoprotective,[ 35 ] anxiolytic,[ 25 ] antiprotozoal,[ 36 ] antisecretory,[ 37 ] antiarthritic,[ 38 ] antibacterial,[ 17 20 ] antifungal,[ 17 ] anti-inflammatory, antioxidant,[ 39 40 ] and inhibitor of mitochondrial complex I properties.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic activity of the leaves fromAnnona cherimolamiller and rutin on alloxan-induced diabetic rats

et al. 2017

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Background:Annona cherimola, known as “chirimoya” has been reported in Mexican traditional medicine for the treatment of diabetes.Objective:The aims of the present study were to validate and assess the traditional use of A. cherimola as an antidiabetic agent.Materials and Methods:The ethanol extract from A. cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg), and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. In addition, oral glucose tolerance test (OGTT) and oral sucrose tolerance test (OSTT) were performed in normoglycemic rats. Molecular docking technique was used to conduct the computational study.Results:Bioassay-guided fractionation of EEAc afforded as major antihyperglycemic compound, rutin. EEAc attenuated postprandial hyperglycemia in acute test using AITD rats (331.5 mg/dL) carrying the glycemic levels to 149.2 mg/dL. Rutin after 2 h, attenuated postprandial hyperglycemia in an acute assay using AITD rats such as EEAc, with maximum effect (150.0 mg/dL) being seen at 4 h. The antihyperglycemic activities of EEAc and rutin were comparable with acarbose (151.3 mg/dL). In the subchronic assay on AITD rats, the EEAc and rutin showed a reduction of the blood glucose levels since the 1st week of treatment, reaching levels similar to normoglycemic state (116.9 mg/kg) that stayed constant for the rest of the assay. OGTT and OSTT showed that EEAc and rutin significantly lowered blood glucose levels in normoglycemic rats at 2 h after a glucose or sucrose load such as acarbose. Computational molecular docking showed that rutin interacted with four amino acids residues in the enzyme α-glucosidase.Conclusion:The results suggest that rutin an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes.SUMMARYThe ethanol extract from Annona cherimola (300 mg/kg, EEAc), subsequent fractions (100 mg/kg) and rutin (30 mg/kg) were studied on alloxan-induced type 2 diabetic (AITD) and normoglycemic rats. The results suggest that rutin; an α-glucosidase inhibitor was responsible in part of the antihyperglycemic activity of A. cherimola. Its in vivo antihyperglycemic activity is in good agreement with the traditional use of A. cherimola for the treatment of diabetes.Abbreviations Used: EEAc: The ethanol extract from Annona cherimola, AITD: Alloxan-induced type 2 diabetic rats, OGTT: Oral glucose tolerance test, OSTT: Oral sucrose tolerance test, DM: Diabetes mellitus

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“…These include the ethanol extract of Phoradendron serotinum leaves tested on peripheral blood mononuclear cells [ 91 ], the aqueous extract of Cnidoscolus chayamansa leaves on baby hamster kidney (BHK) cells [ 92 ], and the aqueous extract of Enterolobium cyclocarpum bark assayed on 3T3 murine preadipocytes [ 82 ]. Additionally, the ethanol extract of Equisetum hyemale aerial parts evaluated on rabbit corneal fibroblasts (SIRC) [ 93 ], the methanol extract of Enterolobium cyclocarpum leaves evaluated on Vero cells (obtained from kidney epithelial cells extracted from the African green monkey (Cercopithecus aethiops) [ 88 ], and the diterpene ent‐kaur‐16‐en‐19‐oic acid, obtained from Annona cherimola , tested on rat embryo primary striatal cultures [ 94 ]. On the other hand, the hydroalcoholic extract of Hura crepitans leaves had an IC 50 = 107.7 μ g/ml in lung fibroblasts [ 95 ].…”

Section: Toxicologymentioning

confidence: 99%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

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Kaurenoic Acid from Pulp of Annona cherimolia in regard to Annonaceae‐induced Parkinsonism

Cited by 13 publications

References 26 publications

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

Chemical Constituents from the Leaves of Annona reticulata and Their Inhibitory Effects on NO Production

Antihyperglycemic activity of the leaves fromAnnona cherimolamiller and rutin on alloxan-induced diabetic rats

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

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