KATAMNESTISCHE UNTERSUCHUNGEN BERUFLICHER CHEMISCH‐ALLERGISCHE KONTAKTEKZEME<sup>1</sup>

Rajka, E.

doi:10.1111/j.1398-9995.1966.tb03131.x

Cited by 10 publications

(4 citation statements)

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“…Perhaps the most important of our observations is about the effect of change of work. Whereas some earlier investigators (Gomez-Orbaneja & Barrientes, 1938;Skog & Tottie, 1961;Rajka, 1966;Peter, 1968) thought a change of occupation would lead to earlier remission of hand dermatitis, our results indicate otherwise. Our findings are in keeping with other investigators (Koch & Peters, 1939;Hunziker & Musso, i960;Neumann, 1966;Forstrom, Pirila & Huju, 1969;Fregert, 1975;Cronin, 1980).…”

Section: Resultscontrasting

confidence: 98%

The outcome of primary irritant hand dermatitis

1983

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Four hundred and sixty-two patients suffering from primary irritant hand dermatitis were sent postal questionnaires after 1-16 years regarding the outcome of their dermatitis. Two hundred and thirteen patients replied (a compliance rate of 46%). Of the 213 replies 188 were accepted for analysis, of whom only 58 (30.8%) had complete remission of their dermatitis, whilst 130 patients (69.2%) had continuous, or intermittent disease. Of sixty-four patients who changed their occupation only twenty-one (32.8%) had complete remission of their dermatitis as opposed to thirty-seven (29.8%) of 124 who continued their occupation after the diagnosis of primary irritant hand dermatitis was made. It would appear that the outcome of primary irritant hand dermatitis is not favourable, even after 10 years, and change of occupation has no significant effect.

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Section: Resultscontrasting

confidence: 98%

The outcome of primary irritant hand dermatitis

1983

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“…Opinions are divided concerning the value of change of occupation for patients who have contracted hand eczema at work. Some authors consider change of occupation to be of value (16,17), while others express doubt (18). After perusal of 10 years' patient material at a Department of Occupational Dermatology in southern Sweden (19) it appeared, as in several other studies (20,21), that no difference in prognosis existed between patients who had changed jobs and those who continued in their original jobs.…”

Section: Changes Of Occupationmentioning

confidence: 99%

Work‐related hand eczema in atopics

Rystedt

1985

Contact Dermatitis

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549 individuals with severe (group 1), 406 with moderate (group 2) atopic dermatitis in childhood, 222 with respiratory allergy but no atopic dermatitis in childhood (group 3), and 199 without personal or family atopy (group 4) were studied as to occupational health symptoms due to hand eczema. In groups 1, 2 and 4, there was a slightly significant difference (P less than 0.05) between the frequency of hand eczema in individuals with and without occupational exposure to chemicals, water, soil or wear (friction). Despite no such work, 55% in group 1 and 44% in group 2 had developed hand eczema. About 1/4 of the atopics in extreme risk occupations, such as ladies' hairdressers and nursing assistants, had not developed hand eczema. Altogether, 9% in groups 1 and 2 and 3% in group 4 had changed their jobs due to hand eczema, the majority from work with to work without exposure to chemicals, water, soil or wear. Social factors had usually contributed to the change. The healing rate after taking up a new occupation was 15% in group 1, 36% in group 2 and 67% (4 out of 6) in group 4. The majority of the patients whose eczema had not healed had improved in their new occupations. It is claimed that medical reasons for change of occupation should be carefully weighed against social reasons.

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“…AD is a complex multifactorial disorder influenced by genetically based immune abnormalities or various environmental factors (6). Also, most AD patients have an atopic background with familial histories of allergies and bronchial asthma (26). Therefore, AD treatment has not been clearly defined.…”

Section: Discussionmentioning

confidence: 99%

α‐Lipoic acid suppresses the development of DNFB‐induced atopic dermatitis‐like symptoms in NC/Nga mice

Kim

Jang

et al. 2010

Experimental Dermatology

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Atopic dermatitis (AD) is a common skin disease that has complex pathogenic mechanisms. Under specific pathogen-free conditions, repeated epicutaneous treatment of 2-4-dinitrofluorobenzene (DNFB) evokes AD-like clinical symptoms in NC/Nga mice. α-Lipoic acid (α-LA; 1, 2-dithiolane-3-pentanoic acid) is a dietary component that is synthesized in bacteria, yeast, plants, and mammals. α-LA and its reduced form, dihydrolipoic acid, are powerful antioxidants that have many physiological functions, including free radical scavenging of reactive oxygen species, generation of cellular antioxidants, chelation of metal ions, and inflammatory suppression. In this study, we investigated whether α-LA suppresses AD-like skin lesions induced by repeated DNFB application in NC/Nga mice. α-LA significantly suppressed production of interferon (IFN)-γ and interleukin (IL)-4 by activated CD4(+) T cells. We found that the oral administration of α-LA reduced AD-like clinical symptoms and inhibited increases of epidermal thickness in DNFB-induced AD-like skin lesions of NC/Nga mice. Furthermore, total serum IgE levels were dramatically reduced by topical α-LA treatment. Our findings suggest that oral administration of α-LA suppresses the development of AD in DNFB-treated NC/Nga mice and reduces IFN-γ and IL-4 production from activated CD4(+) T cells as well as total serum IgE levels.

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KATAMNESTISCHE UNTERSUCHUNGEN BERUFLICHER CHEMISCH‐ALLERGISCHE KONTAKTEKZEME¹

Cited by 10 publications

References 0 publications

The outcome of primary irritant hand dermatitis

The outcome of primary irritant hand dermatitis

Work‐related hand eczema in atopics

α‐Lipoic acid suppresses the development of DNFB‐induced atopic dermatitis‐like symptoms in NC/Nga mice

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KATAMNESTISCHE UNTERSUCHUNGEN BERUFLICHER CHEMISCH‐ALLERGISCHE KONTAKTEKZEME1

Cited by 10 publications

References 0 publications

The outcome of primary irritant hand dermatitis

The outcome of primary irritant hand dermatitis

Work‐related hand eczema in atopics

α‐Lipoic acid suppresses the development of DNFB‐induced atopic dermatitis‐like symptoms in NC/Nga mice

Contact Info

Product

Resources

About

KATAMNESTISCHE UNTERSUCHUNGEN BERUFLICHER CHEMISCH‐ALLERGISCHE KONTAKTEKZEME¹