Katamnestische Untersuchungen an Patienten mit chronischer Urtikaria und ASS-Intoleranz

Abstract

Of a total of 131 patients suffering from chronic urticaria, 15 were cautiously re-exposed to ASA after an initial provocative exposure during an urticaria test programme 2-11 years before. Only 1 of these patients, who had undergone the initial provocative test 7 years earlier, reacted at the same intensity; 1 other patient reacted with much less intense symptoms 4 years after the original test. Among 3 other patients, who merely reacted to ASA intake with urticarial eruptions and did not suffer from chronic urticaria, only 1 presented 4 years after the initial exposure with oedema of the skin and itching. The tolerance threshold was markedly higher. These results suggest that the sensitivity to intolerance-inducing agents is reduced relatively quickly and may subside completely in most cases.

Prevalence of adverse reactions to food in Germany – a population study

“…This holds especially for IgE‐mediated food allergy in early childhood and pseudoallergic adverse reactions to food. For pseudoallergic reactions, data are available from acetylsalicylic acid intolerance, confirmed in DBPCFC, which can no longer be reconfirmed in 50% after 1 year and 90% after 10 years (22).…”