Karyotypic Analysis of 32 Malignant Epithelial Ovarian Tumors

Suppression of tumorigenicity in human ovarian cancer cell lines is controlled by a 2 cM fragment in chromosomal region 6q24-q25

“…Wake et al (1980) ®rst demonstrated a translocation between chromosomes 6 and 14 in the papillary serous subtype of ovarian tumors. Deletions and translocations involving di erent portions of chromosome 6q were subsequently reported by cytogenetic analyses of primary ovarian carcinomas and ovarian cancer cell lines (Buick et al, 1985;Deger et al, 1997;Sheer et al, 1987;Tibiletti et al, 1996;Trent and Salmon, 1981;Whang-Peng et al, 1984). Frequent losses of heterozygosity (LOH) on this chromosome were also observed in primary ovarian tumors (Cliby et al, 1993;Ehlen and Dubeau, 1990;Foulkes et al, 1993;Lee et al, 1990).…”

Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas

“…Our results indicate that several chromosomal regions were non randomly involved in abnormalities. The patients did not all show the same stage of histological grade and there was no relationship between the complexity of chromosome constitution 40~79,XX, fra(1q11) (q32), fra(3p21), fra(5q31), fra(7q22), fra(9q34), fra(11q23), fra(14q24), fra(15q22), fra(17q21), del(12p13), dup(2p11-12), inv11(p15;q23), inv(21p13;q22) [2], t(19:22)(q13;p13), t(21;22)(p13;q13), 2p+ [2] E2 26 II 46;XX, chtb(2p13), chtb(5q31) [3], chtb(7q22), chtb(17q21) [7], del(7q34), del(11p15), fra(11q23), fra(Xq27), i(2p13), t(14;21)(q11;q11) E3 22 II 46;XX, chtb(5q31), del(11p15),(q23), fra(17q21) E4 57 I 46;XX,gap(1p36),(q32) [2],gap(3p21), gap(5q31) [4], fra(5q31) [2], fra(7q22), fra(14q32)…”

“…Chromosomal deletions in cancer cells are often found to contain tumor suppressor genes [7,8]. Structural rearrangements of chromosome arms 1p, 1q, 3p, 3q, 6q, 7p, 9q, 11p, 11q, 17q, 19p, and 19q were identified in ovarian tumors [1][2][3]5]. Taken together, these findings suggest that certain chromosomal abnormalities are important in the pathogenesis of ovarian and endometrial cancers.…”

“…Most of these neoplasms are associated with chromosomal abnormalities and show a constellation of rearrangements such as translocations, deletions, and inversions [1][2][3][4][5]. However, understanding of the molecular genetic and cyto genetic changes associated with ovarian tumor development and disease progression has been limited because of the extreme complexity of the abnormalities [2]. Cyto genetic abnormalities have diagnostic and prognostic value in ovarian carcinoma [2,5,6].…”

“…However, understanding of the molecular genetic and cyto genetic changes associated with ovarian tumor development and disease progression has been limited because of the extreme complexity of the abnormalities [2]. Cyto genetic abnormalities have diagnostic and prognostic value in ovarian carcinoma [2,5,6]. Some chromosomal breakpoints and fragile sites observed in cancer cases are accepted as cancer breakpoints and fragile sites [7,8].…”