The methods of G-, C-and Ag-staining of chromosomes and restaining of the same preparations by various techni ues were used for karyological studies of mice and rats in Azerbaijan. Despite the seemingly stazle karyoty es (2n = 40, 2n = 48 respecitively) respresentatives of the genera Mus and Apodemus exhibite: karyotypic differences indicating that the traditional s ecies in either case were represented by various forms. Two different cytotypes showing the dikerentiation of two taxonomic groups (presumably species) were observed in Transcaucasian Mus. In the resent paper they are termed as "musculus-" and "abbotti"-cytotypes. Three karyoty ic forms [aving various locations of NOR's were established in the subgenus Sylvimus of $e genus Apodemus. At the same time we failed to obtain the cytogenetic proof of presence of the European cytotype of the yellow-necked mouse (A odemus avicollis) in this region. This result automatically removes the problem of inters ecilc hybricfzation of A . sylwaticus and A. flavicollis, which was repeatedly discussed in the Eterature. The cytogenetic study of a Transcaucasian population revealed a system of intraspecific karyotype variation in A. agrurius. For the intraspecific chromosomal polymorphism observed in the chromosome pairs 3, 11 and 12 of Rattus norvegicus our data support the view that variations of heterochromatic and nucleolus organizing regions rather than pericentric inversions are responsible for it. Wild rats (R. rattus) from an endemic Talysh population showed the normal 38-chromosome karyotype.