Karyotype analysis of B-Lymphocytes transformed by Epstein-Barr virus in 21 patients with B cell chronic lymphocytic leukemia

Vahdati, M.; Graafland, H; Emberger, J M

doi:10.1007/bf00274756

Cited by 24 publications

(10 citation statements)

References 35 publications

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“…The most frequent abnormality observed was a 14q + marker chromosome seen in half of the cases studied, with the breakpoint at 14q32. A 14q+ marker has been previously reported in B-CLL (Van den Bergh et al, Autio et al, 1979;Nowell et al, 1981;Vahdati et al, 1983;Gahrton & Robert, 1982;Han et 41, 1984). Other changes in chromosome 14 were also observed in this series, in particular del(l4) (q24) in four patients.…”

Section: Discussionmentioning

confidence: 80%

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Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

Pittman¹,

Catovsky²

1984

Br J Haematol

117

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Lymphocytes from 33 out of 63 patients with B-cell chronic lymphocytic leukaemia (B-CLL) were successfully stimulated for cytogenetic analysis by means of two B-cell mitogens: pokeweed mitogen and lipopolysaccharide-B, used after pretreatment of the cells with neuraminidase and galactose oxidase. All patients had abnormal clones in 30-100% of the cells analysed. Chromosomes more frequently involved were Nos. 1, 3, 6, 11, 12, 13 and 14. The most common abnormality was a marker 14q+ (breakpoint 14q32) seen in 17 cases; trisomy 12 was observed in seven cases. A clinical scoring system was used to investigate the correlation of chromosome abnormalities with prognosis. The group with 14q+ was often associated with features of progressive disease, namely; prolymphocytoid or Richter transformation, refractoriness to therapy, high WBC and advanced staging. A significant difference in survival was observed between patients with 14q+ and the rest: median survival from diagnosis being 45 months and over 64 months, respectively (P less than 0.05); when survival was calculated from the time of chromosome analysis the values were 8 months and more than 41 months, respectively (P less than 0.01). It is suggested that 14q+ is acquired during the evolution of CLL and that this development may be a key event in the clinical progression of B-CLL. Other abnormalities, including trisomy 12, were not found to be associated with a worse prognosis.

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Section: Discussionmentioning

confidence: 80%

“…Deletions and translocations of no. 6 have also been described in CLL (Autio et al, 1979;Schroder et al, 198 1;Gahrton et al, 1980;Vahdati et al, 1983).…”

Section: Discussionmentioning

confidence: 87%

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

Pittman¹,

Catovsky²

1984

Br J Haematol

117

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“…Although these translocations, particularly t(2;7)(p11;q21), have been reported in several cases of splenic marginal zone lymphoma (SMZL), they were unequivocally identified in 12 CLL patients (100)(101)(102)(103)(104). Unfortunately, no data on cell morphology, immunophenotype, or prognosis, are available.…”

Section: T(7;14)(q21;q32) and Variants (Igh/cdk6)mentioning

confidence: 99%

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Braekeleer

Tous

Guéganic

et al. 2016

Molecular and Clinical Oncology

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Abstract. Chronic lymphocytic leukemia (CLL) represents the most common hematological malignancy in Western countries, with a highly heterogeneous clinical course and prognosis. Translocations involving the immunoglobulin (IG) genes are regularly identified. From 2000 to 2014, we identified an IG gene translocation in 18 of the 396 patients investigated at diagnosis (4.6%) and in 17 of the 275 analyzed during follow-up (6.2%). A total of 4 patients in whom the IG translocation was identified at follow-up did not carry the translocation at diagnosis. The IG heavy locus (IGH) was involved in 27 translocations (77.1%), the IG κ locus (IGK) in 1 (2.9%) and the IG λ locus (IGL) in 7 (20.0%). The chromosome band partners of the IG translocations were 18q21 in 16 cases (45.7%), 11q13 and 19q13 in 4 cases each (11.4% each), 8q24 in 3 cases (8.6%), 7q21 in 2 cases (5.7%), whereas 6 other bands were involved once (2.9% each). At present, 35 partner chromosomal bands have been described, but the partner gene has solely been identified in 10 translocations. CLL associated with IG gene translocations is characterized by atypical cell morphology, including plasmacytoid characteristics, and the propensity of being enriched in prolymphocytes. The IG heavy chain variable region (IGHV) mutational status varies between translocations, those with unmutated IGHV presumably involving cells at an earlier stage of B-cell lineage. All the partner genes thus far identified are involved in the control of cell proliferation and/or apoptosis. The translocated partner gene becomes transcriptionally deregulated as a consequence of its transposition into the IG locus. With the exception of t(14;18)(q32;q21) and its variants, prognosis appears to be poor for the other translocations.Therefore, searching for translocations involving not only IGH, but also IGL and IGK, by banding and molecular cytogenetics is required. Furthermore, it is important to identify the partner gene to ensure the patients receive the optimal treatment.

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“…common to both lymphoid and urogenital neoplasms [4][5][6][7], The only reported aberration in prostate carcinoma cells is an iso-(mono-or dicentric?) chromosome 17 long arm [6], Worthy of note is that the 2 cases of B cell chronic lymphocytic leukemia reported by Vahdati et al [8] with the isochromosome 17q (long arm) in their cell lines underwent a prostatectomy at that time.…”

Section: Casementioning

confidence: 99%

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

Shabtai¹,

Lask²,

Kimchi³

et al. 1985

Urol Int

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Concomitance of different primary malignant neoplasms in the same individual has been observed and explained by several possible mechanisms. For urogenital malignancies in concomitance with lymphoid or with intestinal malignancies some data indicate that common etiologic factor(s) with pleiotropic effects may be involved. Concomitance of these particular different primary malignant neoplasms must therefore be kept in mind in the evaluation of patients’ conditions.

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Karyotype analysis of B-Lymphocytes transformed by Epstein-Barr virus in 21 patients with B cell chronic lymphocytic leukemia

Cited by 24 publications

References 35 publications

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

Prognostic significance of chromosome abnormalities in chronic lymphocytic leukaemia

Immunoglobulin gene translocations in chronic lymphocytic leukemia: A report of 35 patients and review of the literature

Concomitance of Urogenital with Lymphoid and Intestinal Malignancies: More Than a Coincidence

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