Karunkeltumor unklarer Dignität

Warga, M.; Szurman, Peter; Rohrbach, Jens Martin

doi:10.1055/s-2005-858534

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…In our study, patients with oncocytoma were generally older (≥ 55 years; median 70 years) which is in accordance with other studies [ 1 , 6 – 8 , 33 , 34 ]. Only Luthra et al reported a patient in his thirties with an oncocytoma [ 7 ].…”

Section: Discussionsupporting

confidence: 92%

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

Clemens

Loeffler

Holz

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Purpose The lacrimal caruncle is composed of numerous structures including different glands as well as hair follicles. Accordingly, the spectrum of benign and malignant lesions is broad, and the clinical diagnosis is often challenging. Here we systematically analyzed excised caruncular tumors over the past 22 years with special emphasis on the clinico-pathological correlation to provide a guidance for clinicians. Methods Retrospective evaluation with clinico-pathologic correlation of surgically removed caruncular tumors between 1998 and 2020 at a tertiary referral center. Results Eighty-two caruncular tumors were identified in the respective period. The patients were between 11 and 85 years of age (mean, 46.8 years; median, 49 years). Nevi (n = 35), cystic lesions (n = 14), oncocytoma (n = 9), papilloma (n = 8), sebaceous gland hyperplasia (n = 8), and reactive lymphoid hyperplasia (n = 4) were observed most frequently. Besides, we are the first reporting herniated orbital fat accompanied by a pyogenic granuloma. 2.4% (n = 2) were malignant tumors (sebaceous gland carcinoma, conjunctival intraepithelial neoplasia with pyogenic granuloma). Conclusion Caruncular tumors show a broad spectrum of mostly benign tumors. They can occur in patients of any age. However, 8/9 oncocytomas and both malignant lesions were detected in patients older than 60 years. Although the clinical diagnosis was confirmed in only 68.3% by the histopathological analysis, the two malignant lesions were identified as such already clinically. Caruncular lesions with a history of growth or other signs of malignancy should be excised followed by detailed histopathological examination to allow a final diagnosis and exclude rare malignant tumors with lethal potential.

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Section: Discussionsupporting

confidence: 92%

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

Clemens

Loeffler

Holz

et al. 2021

Graefes Arch Clin Exp Ophthalmol

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Oculocutaneous Oncocytic Tumors: Clinicopathologic and Immunohistochemical Study of 2 Cases With Literature Review

George¹,

Swanson²,

Newman³

et al. 2007

The American Journal of Dermatopathology

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Oculocutaneous oncocytic tumors (OCOTs) are uncommon neoplasms that have been reported only rarely in the dermatopathology literature and whose immunophenotypic profile has not been well characterized. The clinical, histologic, and immunophenotypic features of 2 cases seen by the authors were assessed, and relevant publications in the literature were reviewed. Both patients with OCOTs were adult women with gradually enlarging, asymptomatic lesions involving the caruncle; they were locally excised. Histologically, the tumors were well-circumscribed nodules comprised of large oxyphilic cells arranged in confluent sheets and forming glandular spaces with secretory material. Microcystic areas and sparse intermingled goblet-cells were also apparent. Nuclear atypia and infiltrative growth were absent. Mitotic activity was absent in one case; a single mitotic figure was identified in the other. Immunostains demonstrated uniform expression of pankeratin and mitochondrial antigens. Both neoplasms were also labeled for markers associated with cutaneous adnexal, lacrimal, and minor salivary glandular tissue, including alpha-1-antitrypsin, gross cystic disease fluid protein-15, carcinoembryonic antigen, lysozyme and MUC1; each case expressed 4 of the 5 substances. Some cells expressed cytokeratins 5/6 and p63 consistent with the presence of basal-type differentiation in a subset of cells. No definite evidence of myoepithelial differentiation was demonstrated, as stains for smooth muscle actin, muscle-specific actin, and S100 protein were negative. Estrogen and progesterone receptor proteins were absent; strong cytoplasmic immunoreactivity for androgen receptor protein was evident, but nuclear staining was absent. The authors conclude that OCOTs show glandular differentiation. A review of the literature disclosed that none of these lesions arising in the caruncle behaved aggressively, in contrast to occasional tumors in other oculocutaneous sites.

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Benign Reactive Lymphoid Hyperplasia of the Caruncle and Plica: Report of 5 Cases

Bagheri

Babsharif

Yazdani

et al. 2007

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Benign reactive lymphoid hyperplasia should be considered in the differential diagnosis of mass lesions of the caruncle and plica semilunaris, especially in young male patients. Histopathologic evaluation and immunohistochemistry studies are necessary to exclude lymphoma and other malignant lesions. Complete surgical excision of the plica or caruncle does not seem to induce significant complications.

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Karunkeltumor unklarer Dignität

Cited by 4 publications

References 17 publications

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn

Oculocutaneous Oncocytic Tumors: Clinicopathologic and Immunohistochemical Study of 2 Cases With Literature Review

Benign Reactive Lymphoid Hyperplasia of the Caruncle and Plica: Report of 5 Cases

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