?Karshi? virus, a new flavivirus (Togaviridae) isolated fromOrnithodoros papillipes (Birula, 1895) ticks in Uzbek S.S.R.

Lvov, D. K.; Neronov, V. M.; Gromashevsky, V. L.; Skvortsova, T M; Berezina, L. K.; Sidorova, G. A.; Zhmaeva, Z. M.; Gofman, Yu A.; Klimenko, S. M.; Fomina, K. B.

doi:10.1007/bf01317998

Cited by 20 publications

(15 citation statements)

References 3 publications

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“…Within the TBFV serocomplex, KSIV has the lowest overall MBE opening energies. Originally isolated from Ornithodoros papillipes ticks in Uzbekistan in 1972 76 it currently does not present history of infection in humans. Conversely, Powassan virus (POWV), another TBFV with negative MBE opening energy, first isolated in Powassan, Ontario, Canada in 1959 from a child who died of acute encephalitis 77 can cause transplacental infection 59 and has been associated with severe neuropathology and death in mice and human 78 .…”

Section: Discussionmentioning

confidence: 99%

Musashi binding elements in Zika and related Flavivirus 3′UTRs: A comparative study in silico

Schneider

Wolfinger

2019

Sci Rep

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Zika virus (ZIKV) belongs to a class of neurotropic viruses that have the ability to cause congenital infection, which can result in microcephaly or fetal demise. Recently, the RNA-binding protein Musashi-1 (Msi1), which mediates the maintenance and self-renewal of stem cells and acts as a translational regulator, has been associated with promoting ZIKV replication, neurotropism, and pathology. Msi1 predominantly binds to single-stranded motifs in the 3′ untranslated region (UTR) of RNA that contain a UAG trinucleotide in their core. We systematically analyzed the properties of Musashi binding elements (MBEs) in the 3′UTR of flaviviruses with a thermodynamic model for RNA folding. Our results indicate that MBEs in ZIKV 3′UTRs occur predominantly in unpaired, single-stranded structural context, thus corroborating experimental observations by a biophysical model of RNA structure formation. Statistical analysis and comparison with related viruses show that ZIKV MBEs are maximally accessible among mosquito-borne flaviviruses. Our study addresses the broader question of whether other emerging arboviruses can cause similar neurotropic effects through the same mechanism in the developing fetus by establishing a link between the biophysical properties of viral RNA and teratogenicity. Moreover, our thermodynamic model can explain recent experimental findings and predict the Msi1-related neurotropic potential of other viruses.

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Section: Discussionmentioning

confidence: 99%

Musashi binding elements in Zika and related Flavivirus 3′UTRs: A comparative study in silico

Schneider

Wolfinger

2019

Sci Rep

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“…Phylogenetic analysis showed that GGYV was more related to the M-TBFV groups although it was discovered from seabird ticks (Major et al 2009 ). KSIV was first isolated from O. papillipes ticks collected in 1971 from Karshinsk steppe, Uzbekistan (Lvov et al 1976 ). Subsequently, it was isolated from H. asiaticum ticks collected in the north of Central Asia (Alma-Ata region of the Kazakh Soviet Socialist Republic) in 1976 (Khutoretskaya et al 1985 ).…”

Section: Families Unassigned To Any Ordermentioning

confidence: 99%

Tick-Borne Viruses

et al. 2018

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Ticks are important vectors for the transmission of pathogens including viruses. The viruses carried by ticks also known as tick-borne viruses (TBVs), contain a large group of viruses with diverse genetic properties and are concluded in two orders, nine families, and at least 12 genera. Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock, while some others may pose risks to public health that are still unclear to us. Herein, we review the current knowledge of TBVs with emphases on the history of virus isolation and identification, tick vectors, and potential pathogenicity to humans and animals, including assigned species as well as the recently discovered and unassigned species. All these will promote our understanding of the diversity of TBVs, and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts.

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“…Within the TBFV serocomplex, KSIV has the lowest overall MBE opening energies. Originally isolated from Ornithodoros papillipes ticks in Uzbekistan in 1972 77 it currently does not present history of infection in humans. Conversely, Powassan virus (POWV), another TBFV with negative MBE opening energy, first isolated in Powassan, Ontario, Canada in 1959 from a child who died of acute encephalitis 78 can cause transplacental infection 59 and has been associated with severe neuropathology and death in mice and human 79 .…”

Section: Discussionmentioning

confidence: 99%

Musashi binding elements in Zika and related Flavivirus 3’UTRs: A comparative studyin silico

Schneider

Wolfinger

2018

Preprint

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Zika virus (ZIKV) belongs to a class of neurotropic viruses that have the ability to cause congenital infection, which can result in microcephaly or fetal demise. Recently, the RNA-binding protein Musashi-1 (Msi1), which mediates the maintenance and self-renewal of stem cells and acts as a translational regulator, has been associated with promoting ZIKV replication, neurotropism, and pathology. Msi1 predominantly binds to single-stranded motifs in the 3' untranslated region (UTR) of RNA that contain a UAG trinucleotide in their core. We systematically analyzed the properties of Musashi binding elements (MBEs) in the 3'UTR of flaviviruses with a thermodynamic model for RNA folding. Our results indicate that MBEs in ZIKV 3'UTRs occur predominantly in unpaired, single-stranded structural context, thus corroborating experimental observations by a biophysical model of RNA structure formation. Statistical analysis and comparison with related viruses show that ZIKV MBEs are maximally accessible among mosquito-borne flaviviruses. Our study addresses the broader question of whether other emerging arboviruses can cause similar neurotropic effects through the same mechanism in the developing fetus by establishing a link between the biophysical properties of viral RNA and teratogenicity. Moreover, our thermodynamic model can explain recent experimental findings and predict the Msi1-related neurotropic potential of other viruses. 2/15

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?Karshi? virus, a new flavivirus (Togaviridae) isolated fromOrnithodoros papillipes (Birula, 1895) ticks in Uzbek S.S.R.

Cited by 20 publications

References 3 publications

Musashi binding elements in Zika and related Flavivirus 3′UTRs: A comparative study in silico

Musashi binding elements in Zika and related Flavivirus 3′UTRs: A comparative study in silico

Tick-Borne Viruses

Musashi binding elements in Zika and related Flavivirus 3’UTRs: A comparative studyin silico

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