Karotis endarterektomili ve şiddetli olmayan karotis arter darlığı olan hastalarda fibrinojen / albümin oranı ve karotis arter hastalığı arasındaki ilişki.

Abstract

Aim: To investigate the relationship between fibrinogen to albumin ratio (FAR) and carotid artery stenosis (CAS). Material and Methods: This study included patients who underwent carotid endarterctomy (CEA) as CEA group and unoperated patients who have CAS less than 50% as non-surgical group. CAS was diagnosed with history and physical examination followed by doppler ultrasonography and carotid angiography. All data retrieved retrospectively from the hospital medical files. Hematologic parameters were measured and recorded. In addition, FAR was calculated. Results: Fifty patients were included in CEA group (70.0 % male, mean age: 71.0 ± 7.7 years) and 60 patients were invluded in non-surgical group (70.0 % male, mean age: 63.9 ± 8.0 years). In logistic regression analysis advanced age, presence of coronary artery disease and FAR were identified as an independent predictor of the development of CAS. In Receiver operating characteristic (ROC) curve analysis, for predicting development of CAS, there were 68.0% sensitivity and 65.0% specificity for FAR (area under the curve [AUC]: 0.669, 95% CI: 0.566-0.771, log rank p = 0.002). Conclusion: We found that FAR were identified as an independent predictor of the development of CAS. FAR could be a potential marker on carotid atherosclerosis in patients. But there is a need large studies including all cardiovascular diseases.