Karnofsky Performance Status predicts overall survival, cancer-specific survival, and progression-free survival following radical cystectomy for urothelial carcinoma

Abstract

Our study suggests the use of KPS to have predictive capacity in terms of OS, CSS, and PFS. This information can be used to inform patients' survival expectations prior to proceeding with radical cystectomy.

Use of preoperative performance status and hemoglobin concentration to predict overall survival for patients aged ≥75 years after radical cystectomy for treatment of bladder cancer

“…However, multivariate analysis for the overall cohort revealed that absence of PLND was not an independent predictive factor for prognosis in combination with the pathological T stage and pathological N stage (hazard ratio 1.440; 95 % confidence interval 0.166-12.52; P = 0.741). Furthermore, the 5-year OS in this study was 62.7 %, which is compatible with other results [5,20]. Second, it is possible that different surgical skill among institutions might affect prognosis and the incidence of complications.…”

“…They reported that the ACCI was associated with clinical outcome for patients undergoing RC. However, investigations of whether comorbidity indices can be used to predict survival of patients with BCa have produced inconsistent results [5]. In our study, neither the CCI nor the ACCI was associated with OS after RC.…”

“…In our cohort, many patients (82.8 %) had no comorbidities. As a result, the number of patients with a low ACCI (≤2), moderate ACCI (3)(4)(5), and high ACCI (>5) was 31 (12.2 %), 210 (82.6 %), and 13 (5.1 %), respectively. These results may have been because of sampling bias.…”

“…These results may have been because of sampling bias. Previous work has found an association between clinical outcomes after RC and PS, namely Karnofsky PS [5] and ECOG PS [16]. The preoperative Hb concentration is reported to be associated with disease-specific survival of patients treated with RC [17,18].…”

“…Therefore, careful patient selection for RC seems to be required, especially for elderly patients with MIBC. Identification of objective preoperative data predictive of the survival of these patients would assist patient selection for RC [5].…”