Karnofsky Performance Scale and Neurological Assessment of Neuro-Oncology Scale as Early Predictor in Glioma

Gunawan, Pricilla Yani; Islam, Andi Asadul; July, Julius; Patellongi, Ilhamjaya; Nasrum, Muhammad; Aninditha, Tiara

doi:10.31557/apjcp.2020.21.11.3387

Cited by 16 publications

(15 citation statements)

References 17 publications

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“…Inclusion criteria were as follows: (1) patients were all advanced ovarian epithelial carcinoma, which was confirmed by pathological examination; (2) met the diagnostic criteria in Obstetrics and Gynecology [ 15 ]; (3) met the diagnostic criteria for Qi deficiency and blood stasis OC in the TCM Diagnosis and Treatment Guidelines for Malignant Tumors [ 16 ]; (4) patients' Karnofsky's performance status (KPS) > 60 [ 17 ], with an estimated survival of more than 6 months; (5) patients were 30 to 70 years old; and (6) patients were aware of the content and purpose of the study and have no objection and voluntarily sign the informed consent form.…”

Section: Methodsmentioning

confidence: 99%

Clinical Efficacy of Yiqi Yangyin Decoction Combined with Docetaxel on Advanced Ovarian Cancer and the Effect on the Levels of Serum Markers VEGF, HE4, and CA125

Wang

Xiao

Shao

et al. 2022

Journal of Healthcare Engineering

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Objective. The study is designed to investigate the therapeutic effect of Yiqi Yangyin Decoction combined with docetaxel on advanced ovarian cancer (OC) patients and the effects on serum markers VEGF, HE4, and CA125. Methods. 92 patients with advanced OC were grouped into the study group and control group. The control group was given the treatment of basic chemotherapy combined with docetaxel. The study group was added the treatment of Yiqi Yangyin Decoction on the basis of the control group. The short-term efficacy, adverse reactions, tumor markers, quality of life, 3-year survival, and T cell subsets of the two groups were observed. Results. Compared to the control group, the study group’s incidence of adverse reactions was lower. VEGF, HE4, and CA125 in the study group were decreased more obviously. The levels of CD3+, CD4+, and CD4+/CD8+ were sharply higher in the study group, while CD8+ was notably reduced. After treatment, the scores of physical health, social function, and mental health in the study group were notably higher than those in the control group. Compared with the control group, the 3-year survival rate of the study group was notably higher, and the therapeutic effect of the study group was obviously better. Conclusion. The combination of Yiqi Yangyin Decoction and docetaxel can improve the body immunity and the therapeutic effect of advanced OC, decrease the incidence of adverse reactions, and prolong the survival time, with good safety and effectiveness.

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Section: Methodsmentioning

confidence: 99%

Clinical Efficacy of Yiqi Yangyin Decoction Combined with Docetaxel on Advanced Ovarian Cancer and the Effect on the Levels of Serum Markers VEGF, HE4, and CA125

Wang

Xiao

Shao

et al. 2022

Journal of Healthcare Engineering

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“…This included patient gender and age, analysis of blood gasses (serum lactate, glucose, hemoglobin (Hb), base excess (BE), and pH), presurgical volumes of tumors, the largest diameter of tumor edema calculated from MR images, tumor histopathology according to the 2007 and 2016 WHO classification ( 2 , 16 ), if it was a primary operation for a brain tumor, and preoperative Karnofsky performance scale ( 17 ) and Charlson Comorbidity Index (CCI) ( 18 ) if a patient had hyperglycemia, diabetes, intraoperative hypotension, pressor treatment during tumor surgery, and presurgical treatment with corticosteroids. The Karnofsky performance scale, ranging from 100 to 0, classifies patients according to their functional impairment, with high scores for high functionality ( 17 ). CCI is based on 17 categories of medical conditions ( 18 ).…”

Section: Methodsmentioning

confidence: 99%

Elevated Serum Lactate in Glioma Patients: Associated Factors

Sitter¹,

Forsmark²,

Solheim³

2022

Front. Oncol.

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IntroductionSerum lactate levels in brain cancer patients correlate with tumor malignancy grading, and serum lactate has been suggested as a potential biomarker and prognostic factor. The purpose of this study was to identify potential sources of elevated serum lactate in patients with brain gliomas by examining factors of importance for serum lactate production and clearance.MethodsIn this cross-sectional study, data were collected from 261 glioma patients who underwent surgery from March 2011 to June 2015. We recorded patient gender, age, blood serum measures of lactate, glucose, pH, hemoglobin and base excess, patient health status, medications, and tumor characteristics. Patients with elevated and normal serum lactate levels were compared, and we explored if there were correlations between the variables. The association of serum lactate with the measured variables was investigated by simple and multivariable linear regression models.Results and DiscussionPatients with elevated serum lactate had higher blood glucose, larger tumor volumes, and more tumor edema; more often needed pressor medication during surgery; and more often received corticosteroid treatment. The investigated variables were highly correlated. Multivariable linear regression indicated that gender, tumor volume, Charlson Comorbidity Index, hyperglycemia, and corticosteroid treatment were associated with serum lactate levels. Histopathology was not an independent factor. In conclusion, comorbidities, hyperglycemia, and presurgical corticosteroid treatment exhibited the strongest association with serum lactate in glioma patients.

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“…The postoperative recovery, short-term prognosis, nursing satisfaction, and complications were compared between the two groups and it is as follows: Postoperative Recovery: It includes the time of stay in intensive care unit, hospitalization time, wakeup time, and the time of defecation for the first time. Short-term Prognosis: The short-term prognosis of the patients was evaluated by the Karnofsky functional status scale (KPS) [ 16 ] (1, 2, and 3 months after operation). The score of KPS scale ranges between 0 and 100.…”

Section: Methodsmentioning

confidence: 99%

“…Short-term Prognosis: The short-term prognosis of the patients was evaluated by the Karnofsky functional status scale (KPS) [ 16 ] (1, 2, and 3 months after operation). The score of KPS scale ranges between 0 and 100.…”

Section: Methodsmentioning

confidence: 99%

“…Postoperative Recovery: It includes the time of stay in intensive care unit, hospitalization time, wakeup time, and the time of defecation for the first time. (2) Short-term Prognosis: e short-term prognosis of the patients was evaluated by the Karnofsky functional status scale (KPS)[16] (1, 2, and 3 months after operation). e score of KPS scale ranges between 0 and 100. e higher the score indicates the better postoperative functional status and prognosis.…”

mentioning

confidence: 99%

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The Role of Establishing Neurosurgical Specialist Nurse Working Group in the Recovery and Prevention of Negative Psychological Emotion after Meningioma Surgery

Luo

Yang

Tang

et al. 2022

Contrast Media & Molecular Imaging

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In this research paper, we will explore the role of establishing a neurosurgical specialist nurse working group in the recovery and prevention of negative psychological emotions after meningioma surgery. For this study, 42 meningioma patients who were treated before the establishment of a neurosurgery specialist nurse working group from January 2019 to December 2019. They were selected as the control group. In contrast, 42 meningioma patients admitted after the establishment of the neurosurgery specialist nurse group from January 2020 to December 2020 were selected as the study group. The postoperative recovery (time of stay in the intensive care unit, time of first eating, wakeup time, time of defecation for the first time, and hospitalization time), short-term prognosis, and nursing satisfaction scores of the two groups were calculated, and the post-traumatic stress disorder scale (PTSD-SS), medical coping style questionnaire (MCMQ), and National Institutes of Health Stroke Scale (NIHSS) were compared. Also, the changes in the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) score contributes to the comprehensive analysis of the role of the establishment of neurosurgical specialist nurse working group in the recovery and prevention of negative psychological emotion after meningioma operation. The satisfaction scores in the study group of patients in physical care, receiving information, support, respect, and nursing process were higher than the control group probability ( P < 0.05 ). The first feeding time, defecation time, out of bed, the stay time in the intensive care unit, and the hospitalization time of the study group were shorter than those of the control group ( P < 0.05 ). Before nursing, there was no difference in NIHSS score, SAS score, and SDS scores between the two groups. However, after nursing, the NIHSS score, SAS score, and SDS score of the study group were fairly lower than the control group. Moreover, the Karnofsky functional status scale (KPS) scores of the two groups increased gradually. The KPS scores of the study group at 1 month, 2 months, and 3 months after operation were significantly higher than those of the control group ( P < 0.05 ). Before nursing, there was no significant difference in the scores of post-traumatic stress disorder between the two groups ( P > 0.05 ). After nursing, the scores of subjective evaluation, symptom avoidance, repeated experience, and social dysfunction in the study group were lower than those in the control group ( P < 0.05 ). Before nursing, there was no significant difference in coping scores between the control group and the research group ( P > 0.05 ), but after nursing, the avoidance and compliance scores of the research group were significantly higher than those of the control group ( P < 0.05 ).Similarly, the scores of avoidance and yield in the study group were significantly lower than those in the control group ( P < 0.05 ). In the study group, 1 patient had an incision infection and 1 patient had epilepsy, and the total incidence of postoperative complications was 4.76%. In the control group, 4 patients had incision infection, 1 case of an intracranial hematoma, 3 cases of deep venous thrombosis, and 3 cases of epilepsy. The total incidence of postoperative complications in the study group was 26.19%, while the incidence of postoperative complications in the study group was lower than in the control group ( P < 0.05 ).

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Karnofsky Performance Scale and Neurological Assessment of Neuro-Oncology Scale as Early Predictor in Glioma

Cited by 16 publications

References 17 publications

Clinical Efficacy of Yiqi Yangyin Decoction Combined with Docetaxel on Advanced Ovarian Cancer and the Effect on the Levels of Serum Markers VEGF, HE4, and CA125

Clinical Efficacy of Yiqi Yangyin Decoction Combined with Docetaxel on Advanced Ovarian Cancer and the Effect on the Levels of Serum Markers VEGF, HE4, and CA125

Elevated Serum Lactate in Glioma Patients: Associated Factors

The Role of Establishing Neurosurgical Specialist Nurse Working Group in the Recovery and Prevention of Negative Psychological Emotion after Meningioma Surgery

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