Kardiovaskuläre Fehlbildungen in Bayern 1984–1991 (Cardiovascular malformations in Bavaria, Germany, 1984–1991)

Abstract

The study presents data on cardiovascular malformations in Bavarian livebirths, born between 1984 and 1991. Cases have been ascertained retrospectively by reviewing hospital records of all children being referred to a children's hospital up to 2 years of age. The classification scheme was based on abnormalities in developmental mechanisms. Among 984,570 livebirths, 7020 cases with structural congenital heart disease were identified. The birth prevalence was 7.1 per 1000 livebirths. Between 1984 and 1991, total prevalence increased from 5.9/10(3) to 8.0/10(3). Prevalence in males was 7.3/10(3) and in females 6.9/10(3). 78.1% of all heart defects were isolated, the remaining 21.9% were associated either with chromosomal abnormalities (9.6%), non-chromosomal syndromes (1.0%), or noncardiac malformations of other organ systems (11.3%). Total fatality rate was 12.0%, with two thirds of deaths occurring within a month of birth or the following month of life. Data were compared with those of the Baltimore-Washington Infant Study. This study presents for the first time regional data on birth prevalences of congenital heart defects in Germany. The classification scheme reduces the wide spectrum of phenotype cardiovascular defects to several pathogenetic groups. The defects in each group may be related to similar causal factors.

Cardiovascular anomalies in children and young adults with Ullrich-Turner syndrome-the erlangen experience

“…In comparison with the CVA prevalence of the general population (0.62%), Bavarian children seem to be at lower risk than the Canadian population (2%). 9,13 Thus, RR of the Italian study calculated on the basis of the Canadian data may not be comparable with ours. However, the incidence of bicuspid aortic valves was very low among Bavarian children compared with more current studies.…”

“…The CVA prevalence in UTS revealed in the Bavarian study, in which data of almost one million children had been analyzed, was 33.3%. 9 Thus, in comparison with this almost unbiased study, our prevalence is within the same dimension, assuming the bias of our study is negligible.…”

“…To assess population-based relative risks (RR), the prevalence of several CVA was compared with that in of Bavarian children. 9 The criteria of CVA assessment in this study was similar to ours and also included bicuspid aortic valves.…”

Facts about the General Medical Care of Adults with Congenital Heart Defects: Experience of a Tertiary Care Center

“…This situation will likely worsen; an analysis performed by the German National Registry for CHD showed that the prevalence of severe CHD has steadily increased since 2008 [26]. Therefore, ACHD severity in primary care will likely increase in upcoming decades, and many ACHD are likely to suffer from severe CHD residua and sequelae [2].…”

“…Congenital heart defect (CHD), the most common isolated congenital organ abnormality, is defined as any type of congenital defect in one or more structures of the heart or blood vessels or a hereditary disorder involving the heart or the great vessels (e.g., Marfan Syndrome or Fabry disease) [1,2].…”