Karaya and ghatti gum as a novel polymer blend in preparation of extended release tablets: optimization by factorial design

Reddy, Suraj Jayadeva; Shivakumar, H. G.; Shyam, Mousumi; Narendra, C; Moin, Afrasim

doi:10.1016/s1773-2247(14)50099-8

Cited by 7 publications

(2 citation statements)

References 27 publications

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“…The plasma half-life of diclofenac is about 1–2 h, and its bioavailability is about 50%. Since it has a shorter half- life, the drug must be administered every 6 h. The increased frequency of administration and its harmful gastric side effects makes it a model drug of choice for the sustained-release dosage form . In this contrast formulation of diclofenac sodium, karaya gum (16–32%), and gum ghatti (4–12%), the time taken for 50% drug release increased from 3.98 to 9.56 h, indicating that drug release rate tends to decrease with increases in the concentration of the polymer (karaya gum or ghatti gum) because the viscosity of the gel layer around the tablet increases with increases in the gum concentration …”

Section: Pharmaceutical Industrymentioning

confidence: 99%

“…Another release matrix composed of gum ghatti and gum karaya as a matrix polymer for tablets containing diclofenac sodium was studied by Reddy and co-workers. 116 Diclofenac sodium is a potent anti-inflammatory, analgesic, and antipyretic used typically for the relief of pain and inflammation. The plasma half-life of diclofenac is about 1–2 h, and its bioavailability is about 50%.…”

Section: Pharmaceutical Industrymentioning

confidence: 99%

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Gum Ghatti: A Comprehensive Review on Production, Processing, Remarkable Properties, and Diverse Applications

Singh,

Priya,

Kumar

et al. 2024

ACS Omega

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Gum ghatti, popularly known as Indian gum and obtained from Anogeissus latifolia, is a complex high-molecular-weight, water-soluble, and swellable nonstarch polysaccharide comprised of magnesium and calcium salts of ghattic acids and multiple monosugars. Unlike other nontimber forest produce, gums ghatti is a low-volume but high-value product. It has several applications and is widely used as food, in pharmaceuticals, and for wastewater treatment and hydrogel formation, and it has attracted a great deal of attention in the fields of energy, environmental science, and nanotechnology. Industrial applications of gum ghatti are primarily due to its excellent emulsification, stabilization, thickening, heat tolerance, pH stability, carrier, and biodegradable properties. However, utilization of gum ghatti is poorly explored and implemented due to a lack of knowledge of its production, processing, and properties. Nevertheless, there has been interest among investigators in recent times for exploring its production, processing, molecular skeleton, and functional properties. This present review focuses on production scenarios, processing aspects, structural and functional properties, and potential applications in the food, pharmaceuticals, nonfood, and other indigenous and industrial usages.

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Section: Pharmaceutical Industrymentioning

confidence: 99%

Section: Pharmaceutical Industrymentioning

confidence: 99%