“…Typical allosteric modulators can either enhance or diminish receptor signalling in response to an anaesthetic, but new drugs may act on both allosteric and orthosteric binding sites (Wisler, Rockman, & Lefkowitz, 2018). Receptor homodimers may also react differently to drugs than heterodimeric receptors (Cechova, Lan, Barthes, Jung, & Ulbrich, 2020). Finally, many of these receptors exhibit tissue‐specific expression and multiple splice variants (Barker et al, 1993; Knierim et al, 2019; Michel et al, 2014) (Figure 2).…”