Kaposiform hemangioendothelioma

Fernández, Y.; Bernabéu-Wittel, Máximo; García-Morillo, Salvador

doi:10.1016/j.ejim.2008.06.008

Cited by 98 publications

(96 citation statements)

References 67 publications

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“…It occurs mostly in children and is rarely observed in adults, with only approximately 20 adult khe patients ever recorded 1,2 . Kaposiform hemangioendothelioma is locally aggressive, does not regress spontaneously, and has a tendency to metastasize locally as well as to regional lymph nodes.…”

Section: Introductionmentioning

confidence: 99%

“…Kaposiform hemangioendothelioma (khe) is a very rare vascular neoplasm that was first described in 1993 by Zukerberg et al 1 . It occurs mostly in children and is rarely observed in adults, with only approximately 20 adult khe patients ever recorded 1,2 .…”

Section: Introductionmentioning

confidence: 99%

“…Cutaneous khe typically appears as an erythematous violet-colour plaque with firm consistency, involving the full thickness of the skin and extending into the subcutaneous tissues. Sometimes, the skin surface shows hemorrhagic areas as the earliest sign of an accompanying Kasabach-Merritt phenomenon (kmp) 3 , which is characterized by profound thrombocytopenia, life-threatening hemorrhage, and lymphangiomatosis 1,3 .…”

Section: Introductionmentioning

confidence: 99%

“…Numerous treatment modalities are available for khe, including surgery, radiation therapy, pharmacologic treatment, and angiography and embolization. Complete surgical removal with a wide margin is the mainstay of treatment; however, total excision might be either impossible or associated with unacceptable morbidity in some cases 1 . In such cases, combined medical treatments with corticosteroids and vincristine have been attempted with varying degrees of success 1,4 .…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Adult-Onset Kaposiform Hemangioendothelioma of the Tongue: Case Report and Review of the Literature

Vashi¹,

Abboud

Bier‐Laning

et al. 2016

Current Oncology

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We present here a very rare clinical case of a 38-year-old man with Kaposiform hemangioendothelioma (khe) of the tongue who presented to our institution with a growth under the left side of the tongue with no pain or discomfort. There were no enlarged lymph nodes and no significant neurologic findings. Diagnostic histopathology confirmed the lesion to be khe. The tumour was removed surgically, and the surgical specimen confirmed the diagnosis. Follow-up at 3 months shows no clinical evidence of recurrence.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Adult-Onset Kaposiform Hemangioendothelioma of the Tongue: Case Report and Review of the Literature

Vashi¹,

Abboud

Bier‐Laning

et al. 2016

Current Oncology

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show abstract

“…Reports on the use of vincristine for the treatment of life-threatening hemangiomas characterised by the Kassabach-Merritt Syndrome (KMS) are anecdotal . These 'hemangiomas' associated with KMS, although closely related to IH delete on the basis of their biological behaviour, have been found to be histologically different from IH, and so the tumors are referred to as kaposiform haemangioendothelioma (KHE) (Enjolras et al, 2008;Fernández et al, 2009).…”

Section: Vincristinementioning

confidence: 99%

Hemangiomas - current therapeutic strategies

Mabeta

Pepper²

2011

Int. J. Dev. Biol.

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Hemangiomas are benign neoplasms of the vasculature frequently encountered in children. Several studies have shown that these tumors are characterized by excessive angiogenesis. Although benign, the lesions can present with complications, and may thus require treatment. There are multiple therapeutic options available for patients with problematic or life threatening hemangiomas, some of which have serious side effects. Randomized clinical trials and evidencebased studies on the efficacy of these treatments is still lacking. The recognition that excessive angiogenesis underlies hemangiogenesis offers an opportunity for the development of safer therapeutic strategies that are based on the inhibition of angiogenesis. We review medical therapies currently employed in the management of hemangiomas and the role of angiogenesis inhibition in hemangioma therapy.

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Unusual Cutaneous Malignancies

Peters¹,

Olencki²

2012

Textbook of Uncommon Cancer

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Kaposiform hemangioendothelioma

Cited by 98 publications

References 67 publications

Adult-Onset Kaposiform Hemangioendothelioma of the Tongue: Case Report and Review of the Literature

Adult-Onset Kaposiform Hemangioendothelioma of the Tongue: Case Report and Review of the Literature

Hemangiomas - current therapeutic strategies

Unusual Cutaneous Malignancies

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