“…1 Hemangiomas constitute the most common tumor of childhood and, though benign, may require systemic therapy to alleviate complications, such as compression of vital structures, coagulopathy (Kasabach-Merritt syndrome), and high output heart failure. [2][3][4] Endothelial malignancies are difficult to treat surgically, because of multifocal growth and potential for distant spread, the latter often arising after successful resection of a primary tumor. 5,6 Thus, increased understanding of the pathogenesis of angiosarcoma is required and may lead to improved therapy.…”