Kaposi Sarcoma With Extensive Pulmonary Involvement in an Immunocompetent Host

Ayalew, Getinet; George, Avrille; Mongia, Shella; Yudis, Carmencita; Ponnambalam, Arvind J.; Sidhu, Gurinder

doi:10.1378/chest.10787

Cited by 2 publications

(2 citation statements)

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“…Although a few cases have been reported as isolated visceral manifestations of KS, it is very uncommon for visceral involvement to occur without skin manifestations [ 18 , 19 ]. Gastrointestinal tract, lungs, liver, and spleen are other visceral sites of involvement.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Kaposi Sarcoma with Osseous Metastases in an Human Immunodeficiency Virus (HIV) Patient: A Remarkable Response to Highly Active Antiretroviral Therapy

et al. 2017

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Patient: Male, 34Final Diagnosis: Pulmonary Kaposi’s sarcoma with bony metastatsesSymptoms: Cough • weight lossMedication: —Clinical Procedure: —Specialty: Infectious DiseasesObjective:Rare diseaseBackground:Kaposi sarcoma (KS) is known to involve the mucocutaneous tissues and the aero-digestive tracts. In acquired immune deficiency syndrome (AIDS) patients, KS has an aggressive course and carries poor prognosis. We present a case of pulmonary KS with osseous metastases as the first presentation of human immunodeficiency virus (HIV) infection in a young male. The lesions impressively decreased in size and numbers following initiation of highly active antiretroviral therapy (HAART).Case Report:A 34-year-old heterosexual male presented with a one month history of cough and 15–20 pound weight loss within six months. Examination revealed oral thrush, decreased breath sounds and crackles on the right lower lung base. Imaging showed a large right perihilar mass with multiple lytic lesions involving thoracic and lumber vertebrae, ribs, sternum, and clavicles. Blood and sputum cultures, smears for acid fast bacilli, and a QUANTIferon gold test were all negative. He tested positive for HIV and his CD4 count was 7 cells/uL. Bronchoscopy with biopsy was unrevealing. Pathology of the right hilar mass was diagnostic of KS. Following initiation of antiretroviral therapy his condition dramatically improved; repeat chest CT scan showed marked regression of the bony and pulmonary lesions.Conclusions:The dual action of HAART on the recovery of the immune system and against human herpes virus 8 (HHV-8) may essentially cause regression of KS lesions.

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Section: Discussionmentioning

confidence: 99%

Pulmonary Kaposi Sarcoma with Osseous Metastases in an Human Immunodeficiency Virus (HIV) Patient: A Remarkable Response to Highly Active Antiretroviral Therapy

et al. 2017

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“…Although a few cases have been reported as isolated visceral manifestations of KS, it is very uncommon for visceral involvement to occur without skin manifestations [4,5] . Visceral disease may affect the gastrointestinal tract, lungs, liver, and spleen.…”

Section: Discussionmentioning

confidence: 99%

Bronchopulmonary Kaposi's sarcoma

Bashar

Innes

Orrell

2015

Respiratory Medicine Case Reports

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Kaposi's sarcoma (KS) is a highly vascular tumour, which was first described by the Hungarian dermatologist Moritz Kaposi Kohn before the discovery of the human immunodeficiency virus (HIV). Historically, KS has been linked to immunosuppression or to elderly male patients, especially in relation to diffuse cutaneous KS. We describe a case of Bronchopulmonary Kaposi's sarcoma in a patient with AIDS who was successfully treated with HAART and Liposomal Doxorubicin chemotherapy.

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Kaposi Sarcoma With Extensive Pulmonary Involvement in an Immunocompetent Host

Cited by 2 publications

References 2 publications

Pulmonary Kaposi Sarcoma with Osseous Metastases in an Human Immunodeficiency Virus (HIV) Patient: A Remarkable Response to Highly Active Antiretroviral Therapy

Pulmonary Kaposi Sarcoma with Osseous Metastases in an Human Immunodeficiency Virus (HIV) Patient: A Remarkable Response to Highly Active Antiretroviral Therapy

Bronchopulmonary Kaposi's sarcoma

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