Kaposi sarcoma: The African HIV epidemic's partner in crime

Davidson, Alan

doi:10.1002/pbc.22412

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“…The fact that Kaposi sarcoma was the single most common malignancy in this study (accounting for 34% of all tumors) is consistent with other reports from Africa [28][29][30] and is undoubtedly related to the high rate of HHV-8 infection. There was a higher incidence of non-Burkitt B-cell lymphoma (42.5% of all B-cell lymphoma) than in HIV-negative children and we noted a propensity for B-cell tumors to develop in unusual sites.…”

Section: Discussionsupporting

confidence: 92%

Malignancies in South African Children With HIV

Davidson

Wainwright

Stones

et al. 2014

Journal of Pediatric Hematology/Oncology

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The study shows more Kaposi sarcoma and fewer primary central nervous system lymphomas among HIV-positive children than that is reported in the developed world, but confirms a higher incidence of non-Burkitt B-cell lymphoma than in HIV-negative children. The high number of non-AIDS-defining malignancies underscores the prevalence of HIV-AIDS in South Africa. The overall survival should improve with universal access to antiretrovirals and earlier diagnosis.

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Section: Discussionsupporting

confidence: 92%