Kaposi Sarcoma-Like Lesions Caused by <i>Candida guilliermondii</i> Infection in a Kidney Transplant Patient

Kim, Soojung; Shin, Jung-Hye; Lee, Kang Wook; Kim, So Hyun; Rao, Babar; Lee, Young

doi:10.5021/ad.2021.33.1.91

Cited by 3 publications

(1 citation statement)

References 5 publications

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“…Throughout the years, this fungus has been mostly collected within cancer and haematology wards, especially in the patients with eating disorders ( 17 , 18 ). Another relatively common group is from dermatology services and the organ transplant service ( 19 , 20 ). Owing to its low prevalence, the exploration of Candida guilliermondii infections lags behind that of more prominent candida species ( 21 ).…”

Section: Discussionmentioning

confidence: 99%

First case report of Candida guilliermondii native left-sided valve endocarditis

Zheng,

Tu,

Jiang

et al. 2023

Front. Cardiovasc. Med.

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Endocarditis, a life-threatening inflammation of the endocardium, is incited by bacteria, fungi, or other pathogenic microorganisms. Fungal endocarditis closely mirrors bacterial endocarditis in clinical signs and symptoms, leading to potential misdiagnoses. Here, we unveil the inaugural confirmed instance of native left-sided valve endocarditis attributed to Candida guilliermondii. Diagnosis was substantiated through valvular biopsies, blood and vegetative cultures. Treatment encompassed surgical excision of vegetations along with a six-week regimen of fluconazole administration (12 mg/kg/day), followed by 4 years of meticulous monitoring, resulting in sustained patient recovery.

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Section: Discussionmentioning

confidence: 99%

First case report of Candida guilliermondii native left-sided valve endocarditis

Zheng,

Tu,

Jiang

et al. 2023

Front. Cardiovasc. Med.

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Meyerozyma guilliermondii species complex: review of current epidemiology, antifungal resistance, and mechanisms

et al. 2022

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Diversity and Antifungal Susceptibilities of Yeasts from Mangroves in Hong Kong, China—A One Health Aspect

Hau,

Shiu,

Tam

et al. 2024

JoF

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While mangrove ecosystems are rich in biodiversity, they are increasingly impacted by climate change and urban pollutants. The current study provides first insights into the emergence of potentially pathogenic yeasts in Hong Kong’s mangroves. Sediment and water samples were collected from ten urban and rural mangroves sites. Initial CHROMagarTM Candida Plus screening, representing the first application of this differential medium for water and soil samples collected from a non-clinical environment, enabled the rapid, preliminary phenotypic identification of yeast isolates from mangroves. Subsequent molecular profiling (ITS and/or 28S nrDNA sequencing) and antifungal drug susceptibility tests were conducted to further elucidate yeast diversity and drug resistance. A diversity of yeasts, including 45 isolates of 18 distinct species across 13 genera/clades, was isolated from sediments and waters from Hong Kong mangroves. Molecular profiling revealed a dominance of the Candida/Lodderomyces clade (44.4%), a group of notorious opportunistic pathogens. The findings also reveal a rich biodiversity of non-Candida/Lodderomyces yeasts in mangroves, including the first reported presence of Apiotrichum domesticum and Crinitomyces flavificans. A potentially novel Yamadazyma species was also discovered. Remarkably, 14.3% of the ubiquitous Candida parapsilosis isolates displayed resistance to multiple antifungal drugs, suggesting that mangroves may be reservoirs of multi-drug resistance. Wildlife, especially migratory birds, may disseminate these hidden threats. With significant knowledge gaps regarding the environmental origins, drug resistance, and public health impacts of pathogenic yeasts, urgent surveillance is needed from a One Health perspective. This study provides an early warning that unrestrained urbanization can unleash resistant pathogens from coastal ecosystems globally. It underscores the necessity for enhanced surveillance studies and interdisciplinary collaboration between clinicians, ornithologists, and environmental microbiologists to effectively monitor and manage this environmental health risk, ensuring the maintenance of ‘One Health’.

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Kaposi Sarcoma-Like Lesions Caused by Candida guilliermondii Infection in a Kidney Transplant Patient

Cited by 3 publications

References 5 publications

First case report of Candida guilliermondii native left-sided valve endocarditis

First case report of Candida guilliermondii native left-sided valve endocarditis

Meyerozyma guilliermondii species complex: review of current epidemiology, antifungal resistance, and mechanisms

Diversity and Antifungal Susceptibilities of Yeasts from Mangroves in Hong Kong, China—A One Health Aspect

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