Kaposi's sarcoma in Nigeria

Onunu, A N; Okoduwa, Cynthia; Eze, Emeka; Adeyekun, AA; Kubeyinje, E. P.; Schwartz, Robert A.

doi:10.1111/j.1365-4632.2007.03016.x

Cited by 24 publications

(22 citation statements)

References 11 publications

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“…We also found that the disease was more frequent in males compared with females (10 : 1 ratio), especially in the AIDS‐associated form where all patients were males. Although KS is known to have a male predominance, the male to female ratio in our patient population is even greater than that found in studies from other countries (male‐female ratio 3 : 1 in large epidemiological studies) . In addition, AIDS‐related cases were mostly younger (between 20 and 45 years) than HIV negative cases (older than 50 years), which corroborates with data from the literature …”

Section: Discussionsupporting

confidence: 90%

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

et al. 2019

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Background Most of the previous reports regarding the clinical features of Kaposi's sarcoma (KS) have been performed in Western and African countries. The clinical characteristics of KS have not been well defined in Han Chinese or Taiwanese patients. In this study, we analyzed the clinical features of KS patients in a Taiwanese medical center. Methods Medical records from Kaohsiung Medical University Hospital over the past 20 years (1996–2016) were comprehensively reviewed. Results There were 55 patients with KS (50 males and 5 females), including 37 patients (67%) with classic disease, 17 patients (31%) with AIDS‐associated disease, and one patient (2%) with immunosuppressive medication‐related disease. The average age was 58.7 years (range 20–87 years), and the average age was younger for AIDS patients (33.8 years) compared with non‐AIDS patients (69.8 years). Among patients with classic KS, lesions were mostly localized to the lower extremities, whereas AIDS‐associated KS patients were more likely to develop disseminated skin lesions, skin lesions on atypical sites (head and neck, trunk), and extracutaneous involvement (particularly oral cavity). The most common underlying diseases were diabetes mellitus (20% of patients) and hepatitis B (15% patients), and 38% of KS patients were smokers. Patients with AIDS‐associated KS usually responded well to chemotherapy, whereas only 32% of patients with non‐AIDS‐associated KS showed complete response to radiotherapy. Conclusions The findings of the current study will serve as important references for clinicians in the diagnosis of KS and may form the basis for the implementation of KS clinical practice guidelines in Taiwan.

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Section: Discussionsupporting

confidence: 90%

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

et al. 2019

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“…5,9,10 Although it is mostly asymptomatic, vitiligo imposes a great deal of psychological stress on sufferers on account of its conspicuousness (especially when contrasted with Black skin) and because it is often erroneously considered to be leprosy by members of the public. This rising trend was also observed by Onunu et al 46 This increase may be explained by the growing number of HIV and acquired immunodeficiency syndrome (AIDS) infections in sub-Saharan Africa. It had an overall frequency of 1.0% but a frequency of 26.2% among those diagnosed with HIV infection and thus featured as the most common HIV-related dermatosis.…”

Section: Discussionsupporting

confidence: 64%

Skin diseases in Nigeria: the Calabar experience

Henshaw

Olasode

2014

Int J Dermatology

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“…4 In Nigeria, with an adult seroprevalence ratio of 5.8%, this disease is a major cause of morbidity and mortality. 5 In an earlier study in this center, there was no convincing evidence that the disease was associated with HIV infection. 6 This is a report of the changing trend of KS in the same center.…”

Section: Introductionmentioning

confidence: 86%

“…6 This current clinical pattern of KS seen is in keeping with reports from Nigeria and other African countries affected by HIV epidemic. 5,10 Kaposi sarcoma was predominantly a disease of men in both the black and white. 3 However, in our study there were 7 males and 4 females (male: female 1.75: 1).…”

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confidence: 99%

Kaposi sarcoma: Changing trend in Calabar, south eastern Nigeria

et al. 2008

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Background/objective: Kaposi sarcoma (KS) is now the most frequently reported malignant skin tumour in some areas of Africa and was endemic in Africa before the advent of the human immunodeficiency virus (HIV) infection. The prevalence has increased with the emergence of HIV infection. The objective of this report is to describe the frequency, current clinical pattern, and anatomic distribution of KS in Calabar, south-eastern Nigeria and compare this with total malignant skin tumour. Method: All the patients with histologic diagnosis of KS presenting to the University of Calabar Teaching Hospital from January 2005 and December 2006 were analyzed as part of the wider study of malignant skin tumorus. Diagnosis of HIV was based upon enzyme linked immunosorbent assay. Results: In our study, there were 11 patients (7 males and 4 females), with a male: female ratio of 1.75: 1. This was the commonest malignant skin tumor (38%) followed by squamous cell carcinoma (SCC) (34.5%) and the age ranged from 21 -60 years (mean 42.9years). Nine patients (81.8%) were HIV positive including the 4 females (age ranged from 21 -45 years) and 2(18.2%) HIV negative, aged 59 and 60years. The lower limb was the commonest site (50%). Atypical lesions involved the eyelids/ nose and penis. Conclusion: KS is now the commonest malignant skin tumour in our region with the HIV related KS as the commonest clinical type. Successful prevention and treatment of HIV infection would reduce the prevalence of this tumour.

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Kaposi's sarcoma in Nigeria

Abstract: The prevalence of HIV-related KS is increasing in Nigeria. There is an increase in the number of women being diagnosed with this form of KS, probably owing to more females having HIV disease.

Cited by 24 publications

References 11 publications

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

Clinical features of Kaposi's sarcoma: experience from a Taiwanese medical center

Skin diseases in Nigeria: the Calabar experience

Kaposi sarcoma: Changing trend in Calabar, south eastern Nigeria

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