Kaposi’s sarcoma in HIV-negative patient with primary myelofi brosis

Abstract

Introduction. Kaposi’s sarcoma (КS) is a multi-focal malignant tumor of vascular origin with a predominant lesion of the skin, involving internal organs and lymph nodes. Epidemic and immunosuppressive variants of the disease are considered to be the most studied and common. The main reason for the development of the immunosuppressive variant is the use of immunosuppressive drugs in patients after transplantation of solid organs. Descriptions of the development of Kaposi’s sarcoma in patients with diseases of the hematopoietic system are rare.Aim — to describe a rare combination of a malignant tumor of vascular origin (Kaposi’s sarcoma) and a chronic myeloproliferative disease: primary myelofi brosis.Main findings. To verify the diagnosis of Kaposi’s sarcoma in a patient with primary myelofi brosis, the following were used: histological, immunohistochemical studies of skin biopsies and the polymerase chain reaction method with detection of a fl uorescent signal in “real time” in biological material samples (peripheral blood, smear from the mucous membrane of the oropharynx, skin biopsies from lesions) with quantitative determination of the activity of the human herpes virus 8. A comprehensive examination made it possible to establish the fi nal diagnosis of multiple malignant neoplasms and recommend treatment.