Kaposi’s sarcoma in a patient after renal transplantation

Little, P. J.; Farthing, Charles; Khader, Abdullah Al; Bunuan, Hernando; Haleem, Abdul

doi:10.1136/pgmj.59.691.325

Cited by 11 publications

(3 citation statements)

References 3 publications

(3 reference statements)

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“…However, the principle of treating a malignancy by allowing recovery from immunosuppression may have application beyond EBV-induced neoplasms-as has been suggested by observations with multifocal Kaposi's sarcoma, a, cytomegalovirus associated tumour.22 2 of our renal recipients whose cyclosporinsteroid therapy was drastically reduced have had stabilisation or complete reversal of multifocal Kaposi tumours without loss of graft function; the longest follow-up with a complete "cure" is almost 2 years. 23 The way in which tumours develop under immunosuppression and can be reversed by a reduction or cessation of therapy should provide insight into, and encouragement for trial of immunostimulation techniques in treating, natural acquired immunodeficiency syndromes (AIDS). …”

Section: Discussionmentioning

confidence: 99%

Reversibility of Lymphomas and Lymphoproliferative Lesions Developing Under Cyclosporin-Steroid Therapy

Starzl¹,

Porter²,

Iwatsuki³

et al. 1984

The Lancet

1,153

451

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SummaryPost-transplant lymphomas or other lymphoproliferative lesions, which were usually associated with Epstein-Barr virus infections, developed in 8, 4, 3, and 2 recipients, respectively, of cadaveric kidney, liver, heart, and heart-lung homografts. Reduction or discontinuance of immunosuppression caused regression of the lesions, often without subsequent rejection of the grafts. Chemotherapy and irradiation were not valuable. The findings may influence policies about treating other kinds of posttransplantation neoplasms.

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Section: Discussionmentioning

confidence: 99%

Reversibility of Lymphomas and Lymphoproliferative Lesions Developing Under Cyclosporin-Steroid Therapy

Starzl¹,

Porter²,

Iwatsuki³

et al. 1984

The Lancet

1,153

451

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“…Zisbord et al (1980) reported complete remission of cutaneous and visceral involvement in a renal transplant recipient. Little et al (1983) controlled Kaposi's lesions without rejection in a renal transplant recipient after reducing cyclosporine to 100 mg per day. Kaposi 's sarcoma has been noted under other conditions of immunosuppression, for example, as a complication of corticosteroid therapy in temporal arteries (Leung et al, 1981).…”

Section: Relationship Of Human CMV To Cancermentioning

confidence: 99%

Cytomegalovirus

1991

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All rights reserved 90-14345 CIP No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher Preface to the First EditionAlthough there are a number of excellent current reviews on one or another aspect of cytomegalovirus, the last comprehensive treatment of this subject was that of Krech et al. (197la). In view of the amazing advances in the virological, epidemiologic, and clinical knowledge of cytomegaloviruses, an up-to-date book is needed. Such a work should cover many areas of expertise and a voluminous technical literature. Each area might have been reviewed and analyzed by workers more expert than myself. However, I have embarked on the entire venture alone in order to attain unity and continuity in this book, characteristics that are not easily achieved in the more popular multiauthored works. I have tried to review the Iiterature and provide a critical summary for each area discussed. To do this, I provide as much of the primary data of the relevant works as needed and not just the qualitative conclusions. Inevitably, the flow of the narrative may be interrupted by dry facts and figures. However, such information is essential to make this a meaningful reference work. But for those not interested in such details, I have provided at what I hope are crucial points critiques and summaries.This book is not an exhaustive review of all the literature. This is probably no Ionger possible or even desirable. By selection, however, one runs the risk of having missed or ignored important papers. I am keenly aware of this, and I wish to apologize for such oversight, if that is possible.I visualize this work as being useful for physicians, scientists, and students interested in the biology of and infection by human cytomegalovirus. I feel that to understand these, the basic virology of this virus and related herpesviruses must be included. Topics that have not advanced a great deal and that are adequately described in available works, such as the anatomic pathology, have not been reviewed in detail. The emphasis has been placed on newer insights in the virology, immunology, serology, epidemiology, and especially clinical aspects of human cytomegalovirus. I wish tobring out the interactions of knowledge in these areas. Part II is a much shorter treatment of the nonhuman cytomegaloviruses, reviewed primarily from the point of view of their contribution to the understanding of the human virus. V vi Preface to the First Edition Finally, I wish to thank Drs. Charles R. Rinaldo, Jr., John A. Armstrong, and Donald N. Medearis for their critical review of the manuscript. Their suggestions were invaluable. Dr. John N. Dowling's thorough review of CMV infection in patients with malignancies was the basis of Section 13.4. I also acknowledge the indispensable and patient secretarial assistance of Ms.The remarkable medical events and advances in knowle...

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“…Since we reported the first case of Kaposi developing in a cyclosporin-treated patient [2], we have had 11 other cases of Kaposi sarcoma developing after transplant [3]. Of the 12,7 received both azathioprine and cyclosporin at some stage or other after the transplantation (all 7 also received prednisolone), 2 patients received azathioprine and prednisolone and the remaining 3 received cyclos porin and prednisolone.…”

Section: Dear Sirmentioning

confidence: 99%