Kaposi's sarcoma: histopathological study of 159 cases from Malawi.

Abstract

The histological features of 168 lesions of Kaposi's sarcoma from 159 patients in Malawi, where the disease is commoner than elsewhere, were characteristic. All showed well-developed areas of tumour and could be grouped fairly readily into those with a mixed pattern, a predominantly spindle cell pattern, and an anaplastic group, though intermediate patterns were seen. Hyaline bodies were present in nearly all tumours of skin. The cell of origin of Kaposi's sarcoma is uncertain and possibly has multipotential capabilities. Differential diagnosis may be difficult. Clinically the lesion may be confused with granuloma pyogenicum and may also be like it histologically. The presence of hyaline bodies and deposits of haemosiderin indicate Kaposi's sarcoma. The spindle cell predominant type may be confused with leiomyoma, leiomyosarcoma, or fibrosarcoma. The presence of hyaline bodies and the formation of vascular channels between spindle cells point to a diagnosis of Kaposi's sarcoma.

Anogenital Lesions: Kaposi's Sarcoma and Its Mimicks

“…Early reports on African KS concentrated on the gender differences and histological features [31, 32]. One publication indicated that the most common presentation was cutaneous; it emphasised the rarity of anogenital location [33].…”

Kaposi sarcoma: A continuing conundrum

“…Anaplastic progression is unusual. 259,260 A nodule can enlarge rapidly, sometimes with osteolytic change in the underlying bone. The undifferentiated spindle cells may be strongly positive for Ulex europaeus agglutinin 1 and CD34 antigen.…”

“…Angioneoplasia may occur in clinically uninvolved perilesional KS skin. [257][258][259] The glomerulus-like vascular formations in early patch stage KS and in some more advanced stages may reflect the histogenesis of KS. 174 As KS progresses, nodules of distorted, endothelialized vessels and non-endothelialized, slit-like spaces may become evident.…”

Kaposi's sarcoma in lymph nodes: histological study of lesions from 16 cases in Malawi.

“…This paper reviews the findings on biopsy of all lymph nodes containing Kaposi's sarcoma received at St Thomas's Hospital from Malawi between January 1969 andSeptember 1975 inclusive. The histopathology of 159 cases of Kaposi's sarcoma of the skin and mucous membranes in patients in Malawi during the same period are discussed in a separate paper (O'Connell, 1977). Received for publication 21 February 1977 Material and methods St Thomas's Hospital Medical School provides the only histopathological service for Malawi, The diagnosis has been made on sections of lymph podes stained with haematoxylin and eosin.…”